Abstract:
AIMS:The oxytocin receptor (OXTR) is implicated in the pathophysiology of autism spectrum disorder (ASD). A recent study found a rare non-synonymous OXTR gene variation, rs35062132 (R376G), associated with ASD in a Japanese population. In order to investigate the association between rare non-synonymous OXTR variations and ASD, we resequenced OXTR and performed association analysis with ASD in a Japanese population. METHODS:We resequenced the OXTR coding region in 213 ASD patients. Rare non-synonymous OXTR variations detected by resequencing were genotyped in 213 patients and 667 controls. RESULTS:We detected three rare non-synonymous variations: rs35062132 (R376G/C), rs151257822 (G334D), and g.8809426G>T (R150S). However, there was no significant association between these rare non-synonymous variations and ASD. CONCLUSIONS:Our present study does not support the contribution of rare non-synonymous OXTR variations to ASD susceptibility in the Japanese population.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Egawa J,Watanabe Y,Shibuya M,Endo T,Sugimoto A,Igeta H,Nunokawa A,Inoue E,Someya Tdoi
10.1111/pcn.12205subject
Has Abstractpub_date
2015-03-01 00:00:00pages
131-5issue
3eissn
1323-1316issn
1440-1819journal_volume
69pub_type
杂志文章abstract::The outcome of first-admission schizophrenic patients at Jichi Medical School Hospital was investigated to identify outcome predictors of schizophrenia among the symptoms at the time of the first hospitalization. The subjects were 62 schizophrenic patients, 29 females and 33 males, consecutively discharged from the De...
journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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journal_title:Psychiatry and clinical neurosciences
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