Abstract:
:The purpose of the present study was to investigate the neural substrates underlying event-related potential (ERP) abnormalities, with respect to the generators of the ERP components in depressed patients. Using an oddball paradigm, ERP from auditory stimuli were recorded from 22 unmedicated patients with current depressive episodes and compared with those from 22 age- and gender-matched normal controls. Cortical current densities of the N100 and P300 components were analyzed using low-resolution electromagnetic tomography (LORETA). Group differences in cortical current density were mapped on a 3-D cortex model. The results revealed that N100 cortical current densities did not differ between the two groups, while P300 cortical current densities were significantly lower in depressed patients over the bilateral temporal lobes, the left frontal region, and the right temporal-parietal area. Furthermore, the cortical area in which the group difference in P300 current density had been identified was remarkably larger over the right than the left hemisphere, thus supporting the hypothesis of right hemisphere dysfunction in depression.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Kawasaki T,Tanaka S,Wang J,Hokama H,Hiramatsu Kdoi
10.1111/j.1440-1819.2004.01195.xsubject
Has Abstractpub_date
2004-02-01 00:00:00pages
68-75issue
1eissn
1323-1316issn
1440-1819pii
1195journal_volume
58pub_type
杂志文章abstract::To estimate the prevalence, severity, and treatment of Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) mental disorders in community populations in Japan, face-to-face household surveys were conducted in four community populations in Japan. A total of 1663 community adults responded (overall re...
journal_title:Psychiatry and clinical neurosciences
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