Abstract:
:MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta-analysis of genome-wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA-137. To explore additional risk variations for schizophrenia, we resequenced MIR137 and performed an association analysis in 1321 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. There were no significant associations between these variations and schizophrenia. Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia.
journal_name
Psychiatry Clin Neuroscijournal_title
Psychiatry and clinical neurosciencesauthors
Egawa J,Nunokawa A,Shibuya M,Watanabe Y,Kaneko N,Igeta H,Someya Tdoi
10.1111/pcn.12047subject
Has Abstractpub_date
2013-05-01 00:00:00pages
277-9issue
4eissn
1323-1316issn
1440-1819journal_volume
67pub_type
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