Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population.

Abstract:

:MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta-analysis of genome-wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA-137. To explore additional risk variations for schizophrenia, we resequenced MIR137 and performed an association analysis in 1321 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. There were no significant associations between these variations and schizophrenia. Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia.

authors

Egawa J,Nunokawa A,Shibuya M,Watanabe Y,Kaneko N,Igeta H,Someya T

doi

10.1111/pcn.12047

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

277-9

issue

4

eissn

1323-1316

issn

1440-1819

journal_volume

67

pub_type

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