Abstract：
:Complex molecular mechanisms control B-cell fate to become a memory or a plasma cell. Interleukin-24 (IL-24) is a class II family cytokine of poorly understood immune function that regulates the cell cycle. We previously observed that IL-24 is strongly expressed in leukemic memory-type B cells. Here we show that IL-24 is also expressed in human follicular B cells; it is more abundant in CD27(+) memory B cells and CD5-expressing B cells, whereas it is low to undetectable in centroblasts and plasma cells. Addition of IL-24 to B cells, cultured in conditions shown to promote plasma cell differentiation, strongly inhibited plasma cell generation and immunoglobulin G (IgG) production. By contrast, IL-24 siRNA increased terminal differentiation of B cells into plasma cells. IL-24 is optimally induced by BCR triggering and CD40 engagement; IL-24 increased CD40-induced B-cell proliferation and modulated the transcription of key factors involved in plasma cell differentiation. It also inhibited activation-induced tyrosine phosphorylation of signal transducer and activator of transcription-3 (STAT-3), and inhibited the transcription of IL-10. Taken together, our results indicate that IL-24 is a novel cytokine involved in T-dependent antigen (Ag)-driven B-cell differentiation and suggest its physiologic role in favoring germinal center B-cell maturation in memory B cells at the expense of plasma cells.
journal_name
Bloodjournal_title
Bloodauthors
Maarof G,Bouchet-Delbos L,Gary-Gouy H,Durand-Gasselin I,Krzysiek R,Dalloul Adoi
10.1182/blood-2009-05-220251subject
Has Abstractpub_date
2010-03-04 00:00:00pages
1718-26issue
9eissn
0006-4971issn
1528-0020pii
blood-2009-05-220251journal_volume
115pub_type
杂志文章相关文献
BLOOD文献大全abstract：:Neutrophils exposed to fluoride ion (F-) respond with a delayed and sustained burst of superoxide anion release that is both preceded by and dependent on the influx of Ca2+ from the extracellular medium. The results of this study demonstrate a similarly delayed and sustained generation of 1,2-diglyceride in F(-)-treat...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-06-15 00:00:00
abstract：:Intravital microscopy was used to monitor leukocyte traffic across rat mesenteric postcapillary venules induced by the inactive terminal complement (C) complex (iTCC) topically applied to ileal mesentery. Leukocytes started rolling within 15 minutes from the administration of iTCC, and by 1 hour they adhered almost co...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.v99.1.185
更新日期：2002-01-01 00:00:00
abstract：:Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cycle. Although the expression of Nox isoforms varies between cell type...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-12-195883
更新日期：2009-08-06 00:00:00
abstract：:Heterogeneity in the human and rat plasma fibrinogen (FBG) gamma chains is due to differential splicing of the primary gamma chain mRNA transcript. The subunit composition of FBG containing the predominant form of the gamma chain is homodimeric (human: A alpha 2, B beta 2, gamma 50-gamma 50; rat: A alpha 2, B beta 2, ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1993-10-15 00:00:00
abstract：:In this issue of Blood, Nagai et al provide evidence that adult T-cell leukemia is hierarchically organized and sustained by a small population of transformed T memory stem cells. ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2015-04-640631
更新日期：2015-06-04 00:00:00
abstract：:The interaction of menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and provides a potential opportunity for treatment of NPM1-mutant (NPM1mut) and MLL-rearranged (MLL-r) leukemias. Concomitant activating driver mutations in the gene encoding the tyrosine kinase FLT3 occur in both leukemias and are particularly comm...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood.2020005037
更新日期：2020-11-19 00:00:00
abstract：:Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8(+) and CD4(+) T cells, respectively. Here, we show that targeting Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) to one of them, the human multilectin DEC-205 receptor,...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-03-148072
更新日期：2008-08-15 00:00:00
abstract：:We have previously demonstrated a significant inverse correlation between circulating thrombopoietin (TPO) levels and peripheral platelet (PLT) counts in patients with thrombocytopenia secondary to megakaryocytic hypoplasia but not in patients with immune thrombocytopenic purpura (ITP; Chang et al, Blood 88:3354, 1996...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1999-04-15 00:00:00
abstract：:In this report, we show that the Src family nonreceptor protein tyrosine kinase (PTK) Lyn associates with aggregated IgA Fc receptor (Fc alpha R) in the monocytic cell line THP-1. Receptor aggregation and subsequent immunoprecipitation of receptor complexes with huIgA adsorbed to nitrocellulose particles shows that Ly...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-01-15 00:00:00
abstract：:We have demonstrated that high molecular weight kininogen (HK) binds specifically on endothelial cells to domain 2/3 of the urokinase receptor (uPAR). Inhibition by vitronectin suggests that kallikrein-cleaved HK (HKa) is antiadhesive. Plasma kallikrein bound to HK cleaves prourokinase to urokinase, initiating cell-as...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-01-15 00:00:00
abstract：:Keeping track of individual cell identifications is imperative to the study of dynamic single-cell behavior over time. Highly motile hematopoietic stem and progenitor cells (HSPCs) migrate quickly and do not adhere, and thus must be imaged very frequently to keep cell identifications. Even worse, they are also flushed...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2017-07-794131
更新日期：2018-03-29 00:00:00
abstract：:Specific monoclonal and polyclonal antibody reagents and a double antigen indirect immunofluorescence microscopy technique were used to visualize coagulation factor V in human bone marrow. Marrow aspirates were smeared directly on glass slides, or washed and cytospun onto glass slides, or processed and plated into a p...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:In this issue of Blood, Mayer et al describe a new method of generating high numbers of Batf3- and Irf8-dependent CD103+ conventional dendritic cells (cDCs), providing new opportunities to study this subset of antigen-presenting cells specialized in crosspresentation. ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2014-08-595298
更新日期：2014-11-13 00:00:00
abstract：:Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.5...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-10-184879
更新日期：2009-05-21 00:00:00
abstract：:Hematopoietic stem cells (HSCs) show pronounced heterogeneity in self-renewal and differentiation behavior, which is reflected in their repopulation kinetics. Here, a single-cell-based mathematical model of HSC organization is used to examine the basis of HSC heterogeneity. Our modeling results, which are based on the...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-05-155374
更新日期：2008-12-15 00:00:00
abstract：:In multiple myeloma (MM), both vascular endothelial (VEGF) and basic fibroblast growth factor (bFGF) promote tumor growth and survival. We have used the novel indolinone BIBF 1000 to study effects of simultaneous inhibition of VEGF, FGF and transforming growth factor-beta on MM cells and their interactions with bone m...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2004-11-4250
更新日期：2006-03-01 00:00:00
abstract：:Early B-cell factor 1 (Ebf1) is a transcription factor with documented dose-dependent functions in normal and malignant B-lymphocyte development. To understand more about the roles of Ebf1 in malignant transformation, we investigated the impact of reduced functional Ebf1 dosage on mouse B-cell progenitors. Gene expres...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2014-12-617282
更新日期：2015-06-25 00:00:00
abstract：:Membrane markers expressed by a transplantable granulocytic leukemia induced in inbred strain 13 guinea pigs by N-nitroso-N-butylurea have been investigated by serologic and immunochemical methods. Although the leukemic myeloblasts have no detectable surface immunoglobulin or Fc receptors, they have been found to synt...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1980-02-01 00:00:00
abstract：:The molecular backgrounds of variants encountered in Afro-Caribbean black individuals and associated with the production of clinically significant antibodies against high-incidence antigens (anti-RH18, anti-RH34) and against Rhe epitopes were determined. We showed that RH:-18 phenotypes are produced by 3 distinct RHCE...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2002-01-0229
更新日期：2002-12-01 00:00:00
abstract：:To elucidate the biochemical basis of megaloblastic hematopoiesis, the cellular content and metabolism of deoxyribonucleoside triphosphates (dNTPs) were investigated using the bone marrow cells from nine patients with untreated vitamin B12 deficiency and one with folic acid deficiency. The marked imbalance among four ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:The replating capability of human multipotential (colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte [CFU-GEMM]) and erythroid (burst-forming unit-erythroid [BFU-E]) progenitors was assessed in vitro as a potential measure of self-renewal using purified, recombinant (r) human (hu) or murine (mu) mast...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:In thrombophilic families, protein S deficiency is clearly associated with venous thrombosis. We aimed to determine whether the same holds true in a population-based case-control study (n = 5317). Subjects were regarded protein S deficient when protein S levels were < 2.5th percentile of the controls. Free and total p...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2013-04-499335
更新日期：2013-10-31 00:00:00
abstract：:We used functional expression cloning in mammalian cells to identify a cDNA clone encoding a hematopoietic growth factor that is mitogenic for the factor-dependent human megakaryoblastic leukemic cell line, MO7E. Analysis of the sequence of this cDNA revealed striking similarity to that of a recently reported novel mu...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:MCL-1 is a Bcl-2 family member that has been described as antiapoptotic in various myeloid neoplasms. Therefore, MCL-1 has been suggested as a potential new therapeutic target. Systemic mastocytosis (SM) is a myeloid neoplasm involving mast cells (MCs) and their progenitors. In the present study, we examined the expre...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2006-07-032714
更新日期：2007-04-01 00:00:00
abstract：:CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent antiangiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. We further demo...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2010-03-274852
更新日期：2010-11-25 00:00:00
abstract：:Noncovalent association between the von Willebrand factor (VWF) propeptide (VWFpp) and mature VWF aids N-terminal multimerization and protein compartmentalization in storage granules. This association is currently thought to dissipate after secretion into blood. In the present study, we examined this proposition by qu...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-10-387548
更新日期：2012-05-17 00:00:00
abstract：:A 37-year-old man of Guyanese origin was found to have homozygous beta-thalassemia without anemia. There were no physical stigmata of thalassemia. The hematocrit value was 41 to 45.8, the mean corpuscular volume was 61 fL, and the mean corpuscular hemoglobin was 18.9 pg. The HbF was 45% with a G gamma:A gamma ratio of...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Although the rheologic behavior of sickle erythrocytes (SS cells) is highly dependent on oxygen tension (pO2) and temperature, very little data exist regarding the effects of deoxygenation and reoxygenation on the rheology of "individual" SS cells at body temperature. We have devised and assessed a new experiment syst...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-04-15 00:00:00
abstract：:In severe human beta-thalassemia, the pathophysiology relates to accumulation of excess alpha-globin chains at the membrane. One hypothesis is that membrane-associated alpha-globin by virtue of it's iron or hemichromes produces oxidation of adjacent membrane proteins. The availability of a mouse model of severe beta-t...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-02-15 00:00:00
abstract：:The complex of the serine protease factor IX (FIX) and its cofactor, factor VIII (FVIII), is crucial for propagation of the intrinsic coagulation cascade. Absence of either factor leads to hemophilia, a disabling disorder marked by excessive hemorrhage after minor trauma. FVIII is the more commonly affected protein, e...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-05-353672
更新日期：2012-01-12 00:00:00
