Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta-agonists.

abstract：BACKGROUND:Studies have demonstrated that high-flow nasal cannula (HFNC) prevents intubation in acute hypoxic respiratory failure when compared with conventional oxygen therapy (COT). However, the data examining routine HFNC use in the immediate postoperative period are less clear. RESEARCH QUESTION:Is routine HFNC us...

journal_title：Chest

authors： Chaudhuri D,Granton D,Wang DX,Burns KEA,Helviz Y,Einav S,Trivedi V,Mauri T,Ricard JD,Mancebo J,Frat JP,Jog S,Hernandez G,Maggiore SM,Mbuagbaw L,Hodgson CL,Jaber S,Goligher EC,Brochard L,Rochwerg B

更新日期：2020-11-01 00:00:00

abstract：:We studied the reproducibility of tests of RM performance in normal elderly subjects and compared their performance with that of patients with COPD. The RM strength was measured as MIP and MEP. The RM endurance was measured using a two-minute incremental threshold loading test. The max load, the average Ppk as %MIP at...

journal_title：Chest

authors： Morrison NJ,Richardson J,Dunn L,Pardy RL

更新日期：1989-01-01 00:00:00

abstract：STUDY OBJECTIVES:Prior to the availability of the oral endothelin antagonist bosentan, most patients with pulmonary arterial hypertension (PAH) were treated with continuously infused prostacyclins. Many patients receiving prostacyclins would have received bosentan if it had been available at the time of their diagnosis...

journal_title：Chest

authors： Suleman N,Frost AE

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Long-term outcomes of awakened survivors of out-of-hospital cardiac arrest (OHCA) are poorly known. RESEARCH QUESTION:What are the month (M) 18 outcomes of survivors of out-of-hospital cardiac arrest (OHCA) who awakened during the first 2 weeks' post-OHCA and their poor-outcome risk factors? STUDY DESIGN A...

journal_title：Chest

authors： Peskine A,Cariou A,Hajage D,Deye N,Guérot E,Dres M,Sonneville R,Lafourcade A,Navarro V,Robert H,Azouvi P,Sharshar T,Bayen E,Luyt CE,Hanox Study Group.

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:No studies have attempted to examine the genetic influence on the habit of snoring. The aim of the present study was to examine whether an association existed between self-reported snoring and family history of snoring and a number of genetic markers. MATERIAL AND METHODS:The data were derived from a primar...

journal_title：Chest

authors： Jennum P,Hein HO,Suadicani P,Sørensen H,Gyntelberg F

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Several cross-sectional and short-term studies suggest that patient-reported outcomes (PROs) may be useful to help predict COPD exacerbations, but evidence from long-term prospective cohort studies is lacking. Our aim was to assess if PROs add to the prediction of exacerbations. METHODS:Four hundred eight p...

journal_title：Chest

authors： Strassmann A,Frei A,Haile SR,Ter Riet G,Puhan MA

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:The purpose of our study was to establish magnetic resonance imaging (MRI) criteria for the diagnosis of pulmonary vascular malformations (PVMs). MATERIALS AND METHODS:Since 1987, 11 patients have been referred for chest MRI at our institution because of findings suggestive of a PVM. They were evaluated with...

journal_title：Chest

authors： Silverman JM,Julien PJ,Herfkens RJ,Pelc NJ

更新日期：1994-11-01 00:00:00

abstract：STUDY OBJECTIVES:To measure the prevalence of exercise-induced bronchospasm (EIB) and to determine its effect on the physical performance response to training in otherwise healthy young adults. DESIGN:Observational, retrospective study. SETTING:Fort Jackson, SC, May to July 1998. PARTICIPANTS:One hundred thirty-seve...

journal_title：Chest

authors： Sonna LA,Angel KC,Sharp MA,Knapik JJ,Patton JF,Lilly CM

更新日期：2001-06-01 00:00:00

abstract：STUDY OBJECTIVES:Solitary fibrous tumors of the pleura (SFTPs) are slow-growing neoplasms. Approximately 800 cases have been reported in the literature to date. The aim of this study was to address our experience with the management of SFTPs and to evaluate the advantage of video-assisted thoracoscopic surgery (VATS) i...

journal_title：Chest

authors： Takahama M,Kushibe K,Kawaguchi T,Kimura M,Taniguchi S

更新日期：2004-03-01 00:00:00

abstract：:The preoperative physiologic assessment of a patient being considered for surgical resection of lung cancer must consider the immediate perioperative risks from comorbid cardiopulmonary disease, the long-term risks of pulmonary disability, and the threat to survival due to inadequately treated lung cancer. As with any...

journal_title：Chest

authors： Beckles MA,Spiro SG,Colice GL,Rudd RM,American College of Chest Physicians.

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:In COPD, a decreased inspiratory capacity to total lung capacity ratio (IC/TLC) is associated with dynamic hyperinflation and poor exercise capacity. The association with upper-extremity force measured by handgrip strength (HGS) and 6-min walk distance (6MWD) has not been previously described. We hypothesize...

journal_title：Chest

authors： Felipe C,Bartolome C,Miguel D,Victor PP

更新日期：2015-10-01 00:00:00

abstract：:A patient had repetitive ventricular fibrillation preceded by alternating ST segment depression and elevation. The ECG changes were confined to the precordial leads only, reflecting subendocardial and transmural ischemia, respectively. It is speculated that the patient exhibited consecutive episodes of subtotal and to...

journal_title：Chest

authors： Rechavia E,Sagie A,Kusniec J,Mager A,Sclarovsky S

更新日期：1988-06-01 00:00:00

abstract：:It has been suggested that spirometry should be incorporated into the routine examination of every patient, analogous to obtaining vital signs. To determine the impact of spirometry on the management of outpatients with respiratory disease, spirometry was performed on 150 consecutive patients (123 men and 27 women, me...

journal_title：Chest

authors： Owens MW,Anderson WM,George RB

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Bedside ultrasound examination could be used to assess jugular venous pressure (JVP), and thus central venous pressure (CVP), more reliably than clinical examination. METHODS:The study was a prospective, blinded evaluation comparing physical examination of external jugular venous pressure (JVPEXT), internal...

journal_title：Chest

authors： Deol GR,Collett N,Ashby A,Schmidt GA

更新日期：2011-01-01 00:00:00

abstract：STUDY OBJECTIVE:Childhood exposure to environmental tobacco smoke (ETS) adversely affects dynamic spirometric indexes as a result of combined early life (including in utero) and current exposure to parental smoking. The aim of our study was to investigate the effect of ETS on lung function and to identify the most sens...

journal_title：Chest

authors： Rizzi M,Sergi M,Andreoli A,Pecis M,Bruschi C,Fanfulla F

更新日期：2004-04-01 00:00:00

abstract：:We wanted to determine the long-term effects of a continuous infusion of PGE1 on DO2 and VO2 in patients with ARDS. Data were obtained from a randomized double-blind multicenter trial, which evaluated the effects of PGE1 on survival in patients with ARDS. Patients were stratified according to treatment and outcome: pl...

journal_title：Chest

authors： Silverman HJ,Slotman G,Bone RC,Maunder R,Hyers TM,Kerstein MD,Ursprung JJ

更新日期：1990-08-01 00:00:00

abstract：:Transforming growth factor (TGF)-beta is a multifunctional protein that initiates its diverse cellular responses by binding to and activating specific type I and type II serine/threonine kinase receptors. TGF-beta can act as a regulator of proliferation, migration, survival, differentiation, and extracellular matrix s...

journal_title：Chest

authors： Bertolino P,Deckers M,Lebrin F,ten Dijke P

更新日期：2005-12-01 00:00:00

abstract：STUDY OBJECTIVES:Biochemical and inflammatory markers in pleural inflammation were evaluated in pediatric cases of parapneumonic effusions, and interleukin (IL)-8 and tumor necrosis factor (TNF)-alpha concentrations were tested for possible differentiation of the complicated nature of effusions. PATIENTS:Twenty-eight ...

journal_title：Chest

authors： Utine GE,Ozcelik U,Yalcin E,Dogru D,Kiper N,Aslan A,Kanra G

更新日期：2005-09-01 00:00:00

abstract：:The therapeutic effects of cuirass ventilation were studied in two patients with bilateral diaphragm paralysis. Negative inspiratory and positive expiratory pressure applied to the cuirass shell was transmitted to the abdominal and thoracic cavities. Diaphragm excursion was enhanced. Nocturnal cuirass ventilation appe...

journal_title：Chest

authors： Driver AG,Blackburn BB,Marcuard SP,Austin EH Jr

更新日期：1987-10-01 00:00:00

abstract：:Fifteen patients in the early stages of the adult respiratory distress syndrome with severe hypoxemia who were capable of maintaining adequate spontaneous ventilation were treated with continuous positive airway pressure (CPAP). The optimal level of CPAP was adjusted for each patient to achieve the highest oxygenation...

journal_title：Chest

authors： Venus B,Jacobs HK,Lim L

更新日期：1979-09-01 00:00:00

abstract：:Bitolterol mesylate (WIN 37284) is alpha-[tert-butylaminomethyl]-3,4-dihydroxybenzyl alcohol 3,4-di(p-toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is "prodrug" which is inactive until altered in the body. Th...

journal_title：Chest

authors： Kass I,Mingo TS

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:International time trends in asthma mortality have played an important sentinel role in the identification of two epidemics of asthma mortality in some countries in the 1960s and the 1970s and 1980s. Since then, little attention has been paid to the ongoing international time trends. METHODS:Country-specifi...

journal_title：Chest

authors： Wijesinghe M,Weatherall M,Perrin K,Crane J,Beasley R

更新日期：2009-04-01 00:00:00

abstract：:A patient undergoing radical extrapleural pneumonectomy for epithelioid malignant mesothelioma developed acute paraplegia postoperatively related to long-segment spinal cord ischemia. The usual area of concern for this complication is the T9 to T12 area where the artery of Adamkiewicz is most likely to originate. In t...

journal_title：Chest

authors： Ural K,Jakob K,Lato S,Gilly G,Landreneau R

更新日期：2014-08-01 00:00:00

abstract：:Plug closure of patent ductus arteriosus without thoracotomy is reliable and can be a good alternative to surgical closure for selected patients. We report our experiences with plug closure in 87 consecutive patients (age range, 3 to 38 years). Closure was successful in 83 patients (95 percent). There has been no mort...

journal_title：Chest

authors： Kitamura S,Sato K,Naito Y,Shimizu Y,Fujino M

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:COPD and hypertension both increase the risk of congestive heart failure (CHF). Current clinical trials do not inform the selection of combination antihypertensive therapy among patients with COPD. We performed a comparative effectiveness study to investigate whether choice of dual agent antihypertensive the...

journal_title：Chest

authors： Herrin MA,Feemster LC,Crothers K,Uman JE,Bryson CL,Au DH

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Prostasin, a trypsin-like serine protease, is a channel-activating protease and major regulator of epithelial sodium channel-mediated sodium absorption. Its direct inhibition by camostat represents a potential approach to inhibiting sodium transport in cystic fibrosis (CF). METHODS:To determine whether a to...

journal_title：Chest

authors： Rowe SM,Reeves G,Hathorne H,Solomon GM,Abbi S,Renard D,Lock R,Zhou P,Danahay H,Clancy JP,Waltz DA

更新日期：2013-07-01 00:00:00

abstract：:We evaluated two patients with systemic cholesterol embolization (SCE) associated with the development of pleural effusions. These two patients had evidence of atherosclerosis and presented with livedo reticularis, renal insufficiency, and gangrenous cutaneous changes as manifestations of their SCE. In both cases, clo...

journal_title：Chest

authors： Kollef MH,McCormack MT,Kristo DA,Reddy VV

更新日期：1993-03-01 00:00:00

abstract：:Fifty-seven patients with rheumatoid arthritis (RA) were treated in hospital for diffuse interstitial lung fibrosis. Although interstitial fibrosis (either on the basis of lung function tests or chest roentgenograms or both) is fairly common among patients with RA, according to this study interstitial fibrosis of suff...

journal_title：Chest

authors： Hakala M

更新日期：1988-01-01 00:00:00

abstract：:Between January 1990 and August 1991, there were 37 patients admitted to our Department of Internal Medicine with hematologic malignancies or solid tumors who showed colonization of the respiratory tract with Pseudomonas cepacia. Extensive surveillance cultures of the environmental surfaces and respiratory equipment o...

journal_title：Chest

authors： Yamagishi Y,Fujita J,Takigawa K,Negayama K,Nakazawa T,Takahara J

更新日期：1993-06-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the efficacy of standard medical therapy (ST) and noninvasive mechanical ventilation additional to standard medical therapy in hypercapnic acute respiratory failure (HARF). DESIGN:Single center, prospective, randomized, controlled study. SETTING:Pulmonary medicine directed critical care uni...

journal_title：Chest

authors： Celikel T,Sungur M,Ceyhan B,Karakurt S

更新日期：1998-12-01 00:00:00