Abstract:
OBJECTIVES:Ammonium perfluorooctanoate (APFO) is a biopersistent surfactant used in the manufacture of several types of fluoropolymers. Based on previous findings of increased serum lipid levels associated with exposure to APFO, we evaluated ischaemic heart disease (IHD) mortality in a cohort of occupationally exposed workers. METHODS:Relative risks (RR) were estimated from exposure-response analyses of cumulative exposure measures using proportional hazards regression models. RESULTS:239 IHD deaths have occurred in the cohort of 4747 workers with work histories from 1948 through 2002. RR estimates indicate no statistically significant increased mortality risk for IHD associated with estimated cumulative exposure. We observed a positive trend only at an exposure lag of 10 years. This finding was not reproduced in other 5-year exposure lags and was attenuated when different cutpoints for exposure categorisation were used. CONCLUSION:This exposure-response study shows no convincing evidence of increased IHD mortality risk for APFO-exposed workers at this plant. Further studies evaluating the incidence of IHD are being conducted.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Sakr CJ,Symons JM,Kreckmann KH,Leonard RCdoi
10.1136/oem.2008.041582subject
Has Abstractpub_date
2009-10-01 00:00:00pages
699-703issue
10eissn
1351-0711issn
1470-7926pii
oem.2008.041582journal_volume
66pub_type
杂志文章abstract:BACKGROUND:Assessment of exposure assessment to metal working fluids (MWF) has almost exclusively focused on inhalation exposure. AIMS:To assess levels of, and factors affecting, dermal and inhalation exposure to semi-synthetic MWF, and to identify suitable dermal exposure grouping schemes among metal workers for an e...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.015396
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:To obtain knowledge about the use and distribution of hazardous chemicals in Danish industry. This knowledge is used to regulate the occupational environment and prevent hazardous exposure. METHODS:A national survey on the use of chemicals was carried out in 1989 in a stratified sample of 1448 Danish busine...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.7.454
更新日期:1995-07-01 00:00:00
abstract:AIM:To compare two different methods for assessment of postural load and duration of computer use in office workers. METHODS:The study population existed of 87 computer workers. Questionnaire data about exposure were compared with exposures measured by a standardised or objective method. Measuring true exposure to pos...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.013219
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:There have been few studies of work history and mortality risks in medical radiation workers. We expanded by 11 years and more outcomes our previous study of mortality risks and work history, a proxy for radiation exposure. METHODS:Using Cox proportional hazards models, we estimated mortality risks accordin...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101859
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To assess if improvement of working conditions related to heat stress was associated with improved kidney health outcomes among sugarcane harvest workers in Chichigalpa, Nicaragua, a region heavily affected by the epidemic of chronic kidney disease of non-traditional origin. METHODS:Based on our findings du...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106406
更新日期:2020-08-01 00:00:00
abstract:AIMS:To test whether (1) physically demanding work is less frequent for older than younger employees, and whether (2) the association of physically demanding work with decline of physical functioning is stronger for older employees than their younger counterparts. The gender differences in these associations were exami...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014035
更新日期:2005-02-01 00:00:00
abstract:AIMS:To investigate the hypothesis that long term exposure to excessive noise can increase the risk of ischaemic heart disease. METHODS:A case-control design, nested within a cohort of nuclear power workers employed at two sites in England over the period 1950-98, was used. Cases were men who died from ischaemic heart...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.026245
更新日期:2006-12-01 00:00:00
abstract:CONTEXT:More than 400,000 workers annually receive a measurable radiation dose and may be at increased risk of radiation-induced leukaemia. It is unclear whether leukaemia risk is elevated with protracted, low-dose exposure. OBJECTIVE:We conducted a meta-analysis examining the relationship between protracted low-dose ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/oem.2009.054684
更新日期:2011-06-01 00:00:00
abstract:AIMS:To assess the prevalence of general health status, use of sleep medication, and use of medication for cardiovascular diseases, and to study their relation to aircraft noise exposure. METHODS:These health indicators were measured by a cross-sectional survey among 11 812 respondents living within a radius of 25 km ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2002.005488
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:Violence from care recipients and family members, including both verbal and physical abuse, is a serious occupational hazard for healthcare and social assistance workers. Most workplace violence studies in this sector focus on hospitals and other institutional settings. This study examined verbal abuse in a l...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105604
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:This paper describes findings from the study of chronic bronchitis (CB) incidence after occupational exposure to ionising radiation among workers employed at Russian Mayak Production Association (PA) during 1948 and 1982 and followed up until 2008 based on 'Mayak Worker Dosimetry System 2008'. METHODS:Analy...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-103283
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:Occupational pesticide exposure is associated with a wide range of diseases, including lung diseases, but it is largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104787
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:An association has previously been reported between finger blanching and hearing difficulties, but only in workers with exposure to noise and hand transmitted vibration (HTV). AIMS:To explore the association in a community sample, including cases who lacked occupational exposure to noise or HTV. METHOD:A q...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.9.640
更新日期:2002-09-01 00:00:00
abstract:AIMS:To investigate the acute systemic inflammatory response to welding fume exposure. METHODS:Twenty four welders (42% smokers) and 13 non-exposed controls (23% smokers) were monitored at a welding school. Exposure to fine particulate matter (PM2.5) was assessed using cyclone samplers. Markers of systemic inflammatio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014795
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Few studies have investigated cancer risks in carbon black workers and the findings were inconclusive. METHODS:The current study explores the mortality of a cohort of 1535 male German blue-collar workers employed at a carbon black manufacturing plant for at least one year between 1960 and 1998. Vital status...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.026526
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of enzyme sensitisation in the detergent industry. METHODS:A cross sectional study was conducted in a detergent factory. Sensitisation to enzymes was examined by skin prick and radioallergosorbent (RAST) tests. 76 Workers were tested; 40 in manufacturing, packing, and maintenance, a...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.2.121
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVES:To understand the variations of selenium (Se) concentration relative to changes in occupational exposure to coal dust, taking into account age and changes in smoking habits in miners surveyed twice, in 1990 and 1994. To better understand the relation of Se concentration with glutathione peroxidase activities...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.4.239
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVES:Rates of surgically treated carpal tunnel syndrome (CTS) among blue- and white-collar workers and housewives in the general population were compared. METHODS:Surgically treated cases of idiopathic CTS were investigated among 25-59-year-old residents of Tuscany, Italy, during 1997-2000, based on obligatory d...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.040212
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:The main objective was to study the acute vascular effects in the hands of normal healthy subjects of a complex vibration spectrum similar to that generated by many industrial hand held tools. The effects of repeated bouts of vibrations and alterations in the intensity of vibration were also studied. METHOD...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.10.663
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVES:Rhinitis is common, but the risk factors are not well described. To investigate the association between current rhinitis and pesticide use, we used data from 2245 Iowa commercial pesticide applicators in the Agricultural Health Study. METHODS:Using logistic regression models adjusted for age, education and ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.041798
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:To verify in vivo whether lung cinescintigraphy confirms the effect of asbestos on the patency of the smallest airways and on the efficiency of mucociliary clearance in asbestos cement workers. METHODS:39 male subjects were examined: 30 asbestos cement workers and nine workers never exposed to occupational ...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章
doi:10.1136/oem.53.9.628
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk. METHODS:Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial ca...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2009.052571
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The erection of mobile telephone base stations in inhabited areas has raised concerns about possible health effects caused by emitted microwaves. METHODS:In a cross-sectional study of randomly selected inhabitants living in urban and rural areas for more than one year near to 10 selected base stations, 365 ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.020784
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Systematic assessments of the effectiveness of interventions to prevent work related eye injuries are needed. AIM:To investigate the long term effectiveness of a multicomponent prevention campaign. METHODS:The campaign (conducted in collaboration with the local Employers' Association and Trade Unions) targ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.019570
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample fr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.018754
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVES:To explore whether the inhalation of coal mine dust increases the risk of premature death in miners, a survival analysis was conducted in a cohort of 2738 patients with simple pneumoconiosis in the Huai-Bei coal mine, in China. METHODS:Age specific mortalities were calculated by disease severity in terms of...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.2.129
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Fetal growth restriction has been inconsistently associated with maternal exposure to elevated levels of traffic-related air pollution. OBJECTIVE:We investigated the relationship between an individualised measure of fetal growth and maternal exposure to a specific marker for traffic-related air pollution. ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100509
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:The aim was to test if targeting managers with an educational intervention reduces absence among pregnant employees. METHODS:The study was a non-blinded cluster randomised trial conducted in hospitals and daycare institutions from two administrative Danish Regions and two Danish municipalities. Clusters (wor...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106794
更新日期:2021-01-12 00:00:00
abstract:OBJECTIVES:To appraise epidemiological evidence of the purported association between residential exposure to power frequency magnetic fields and adult cancers. METHODS:Literature review and epidemiological evaluation. RESULTS:Seven epidemiological studies have been conducted on the risk of cancer among adults in rela...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.53.8.505
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVES:Sick building syndrome (SBS) is described as a group of symptoms attributed to the physical environment of specific buildings. Isolating particular environmental features responsible for the symptoms has proved difficult. This study explores the role and significance of the physical and psychosocial work env...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.022889
更新日期:2006-04-01 00:00:00