Abstract:
OBJECTIVES:To verify in vivo whether lung cinescintigraphy confirms the effect of asbestos on the patency of the smallest airways and on the efficiency of mucociliary clearance in asbestos cement workers. METHODS:39 male subjects were examined: 30 asbestos cement workers and nine workers never exposed to occupational respiratory irritants. All subjects had a chest radiograph (International Labour Organisation (ILO) 1980); standard questionnaire on chronic bronchitis; spirometry; arterial blood gas analysis; carbon monoxide transfer factor (TLcosb); pulmonary O2 and CO2 ductances (DuO2, DuCO2); electrocardiogram; and lung cinescintigraphy after radioaerosol inhalation for the measurement of mucociliary clearance time in vivo in the smallest ciliated airways and for the assessment of radioaerosol deposition in alveoli (alveolar deposition index). RESULTS:Apart from nine non-exposed subjects, the 30 asbestos cement workers were so classified on the basis of chest radiography: nine of them as healthy exposed, 10 with pleural plaques, and 11 with asbestosis. The four groups had similar ages, work seniority, and smoking habits. Exercise dyspnoea was significantly more frequent in asbestos cement workers. Lung function variables of workers with effects related to asbestos were significantly lower than the other two groups. The PaO2, TLcOsb and DuO2 mean values were significantly lower in exposed workers than non-exposed. The mean PacO2 value was significantly higher in the asbestosis group than in the other three groups. Workers with effects related to asbestos showed a significantly lower alveolar deposition index and a significantly higher mucociliary clearance time than the other two groups. Subjects with asbestosis showed similar differences from those with pleural plaques. CONCLUSIONS:Lung cinescintigraphy confirms in vivo the effects of asbestos on bronchiolar and alveolar patency and on efficiency of mucociliary clearance in the smallest ciliated airways. Finally, lung cinescintigraphic variables are able to discriminate workers with asbestosis from those with pleural plaques.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Di Lorenzo L,Mele M,Pegorari MM,Fratello A,Zocchetti C,Capozzi Ddoi
10.1136/oem.53.9.628subject
Has Abstractpub_date
1996-09-01 00:00:00pages
628-35issue
9eissn
1351-0711issn
1470-7926journal_volume
53pub_type
临床试验,杂志文章abstract:OBJECTIVES:There have been few studies of work history and mortality risks in medical radiation workers. We expanded by 11 years and more outcomes our previous study of mortality risks and work history, a proxy for radiation exposure. METHODS:Using Cox proportional hazards models, we estimated mortality risks accordin...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101859
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to determine whether self-reported occupational exposure to cleaning/disinfecting agents in hospital workers is accurate, in comparison to expert assessment, taken to be the gold standard. METHODS:In the Epidemiological Study of the Genetics and Environment of Asthma (EGEA), partici...
journal_title:Occupational and environmental medicine
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abstract:OBJECTIVE:The aim was to test if targeting managers with an educational intervention reduces absence among pregnant employees. METHODS:The study was a non-blinded cluster randomised trial conducted in hospitals and daycare institutions from two administrative Danish Regions and two Danish municipalities. Clusters (wor...
journal_title:Occupational and environmental medicine
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104785
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:The aim was to investigate associations between exposure to mineral fibres and dust, and cancer in subsites within the large bowel. DESIGN:Pooled retrospective cohort studies. SUBJECTS AND SETTINGS:Blue collar workers, employed for at least one year in different trades; asbestos cement or cement workers (n ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.2.95
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:To investigate whether there is a relationship between fatigue and sickness absence. Two additional hypotheses were based on the theoretical distinction between involuntary, health related absence and voluntary, attitudinal absence. In the literature, the former term is usually used to describe long term sic...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
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更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:Occupational pesticide exposure is associated with a wide range of diseases, including lung diseases, but it is largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:To confirm or refute the hypothesis that organic farmers have higher sperm concentrations than traditional farmers. METHODS:Traditional and organic farmers were selected randomly from central registers, and 171 traditional farmers and 85 organic farmers delivered one semen sample before the start of the spr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.2.139
更新日期:1999-02-01 00:00:00
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journal_title:Occupational and environmental medicine
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更新日期:2013-08-01 00:00:00
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journal_title:Occupational and environmental medicine
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更新日期:1995-07-01 00:00:00
abstract:OBJECTIVES:Epidemiological studies have shown inconsistent effects on immunological parameters in subjects exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this study we investigated changes in humoral immunity and prevalence of atopic diseases among workers from a Dutch historical cohort occupationally expose...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.058016
更新日期:2011-06-01 00:00:00
abstract::Male Wistar rats were exposed to two types of magnesium sulphate whiskers by inhalation for six hours a day, five days a week, for four weeks (sub-chronic study), or for one year (chronic study) to clarify the biological effects of the whiskers. There were few whiskers detected in the rat lungs even at one day after t...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.7.492
更新日期:1994-07-01 00:00:00
abstract::The International Agency for Research on Cancer has classified occupational exposure as a painter as 'carcinogenic to humans', largely based on increased risks of bladder and lung cancer. A meta-analysis, including more than 2900 incident cases or deaths from bladder cancer among painters reported in 41 cohort (n=2), ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.2009.051565
更新日期:2010-08-01 00:00:00
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journal_title:Occupational and environmental medicine
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更新日期:2016-08-01 00:00:00
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journal_title:Occupational and environmental medicine
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更新日期:2007-10-01 00:00:00
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journal_title:Occupational and environmental medicine
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doi:10.1136/oemed-2012-100924
更新日期:2013-03-01 00:00:00
abstract:AIMS:To assess potential alterations of the nasal mucosa by clinical and histopathological evaluation of workers exposed to sulphuric acid mists at anodising plants, correlating the findings with duration of exposure and sulphuric acid concentrations in the air, and comparing them with a control group. METHODS:Fifty t...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/oem.60.6.395
更新日期:2003-06-01 00:00:00
abstract:AIMS:This study examines the impact of work-related psychosocial and mechanical exposure on the development of low back pain (LBP) in the general working population. METHODS:A randomly drawn cohort from the general population in Norway aged 18-66 years was followed up for 3 years (n=12 550, response rate at baseline=6...
journal_title:Occupational and environmental medicine
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更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk. We used updated diazinon exposure and cancer incidence inform...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102728
更新日期:2015-07-01 00:00:00
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journal_title:Occupational and environmental medicine
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doi:10.1136/oem.2007.033878
更新日期:2008-04-01 00:00:00
abstract:AIMS:To examine whether asthma induced by exposure to aluminium potroom emissions (potroom asthma) is associated with inflammatory changes in the airways. METHODS:Bronchial biopsy specimens from 20 asthmatic workers (8 non-smokers and 12 smokers), 15 healthy workers (8 non-smokers and 7 smokers), and 10 non-exposed co...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
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更新日期:2004-09-01 00:00:00
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journal_title:Occupational and environmental medicine
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更新日期:2020-06-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.10.663
更新日期:1994-10-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/oem.52.9.600
更新日期:1995-09-01 00:00:00
abstract:INTRODUCTION:Analyses of secular trends in work-related fatal injury in New Zealand have previously only considered the total working population, potentially hiding trends for important subgroups of workers. This paper examines trends in work-related fatalities in worker subgroups between 2005 and 2014 to indicate wher...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106812
更新日期:2020-10-26 00:00:00
abstract:AIM:To determine the prevalence of chronic fatigue syndrome (CFS)-like caseness in the working population. METHODS:Using data from the prospective Maastricht Cohort Study on Fatigue at Work, the prevalence and incidence of CFS-like cases (employees meeting research criteria for CFS) were determined among 5499 employee...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
abstract:OBJECTIVES:To investigate the association between occupational exposure to disinfectants/antiseptics used for hand hygiene and asthma control in nurses. METHODS:In 2014, we invited female nurses with asthma drawn from the Nurses' Health Study II to complete two supplemental questionnaires on their occupation and asthm...
journal_title:Occupational and environmental medicine
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更新日期:2018-05-01 00:00:00
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journal_title:Occupational and environmental medicine
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更新日期:2013-04-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.2008.039883
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested that occupational exposure to styrene is associated with increased serum levels of the anterior pituitary hormone prolactin (PRL). AIMS:To test the hypotheses that: (1) the effect of styrene exposure on PRL secretion is an acute effect, not a subchronic or chronic effect; (2)...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2002.005561
更新日期:2004-04-01 00:00:00