Abstract:
OBJECTIVES:Occupational pesticide exposure is associated with a wide range of diseases, including lung diseases, but it is largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between occupational exposure to pesticides and genome-wide DNA methylation sites. METHODS:1561 subjects of LifeLines were included with either no (n=1392), low (n=108) or high (n=61) exposure to any type of pesticides (estimated based on current or last held job). Blood DNA methylation levels were measured using Illumina 450K arrays. Associations between pesticide exposure and 420 938 methylation sites (CpGs) were assessed using robust linear regression adjusted for appropriate confounders. In addition, we performed genome-wide stratified and interaction analyses by gender, smoking and airway obstruction status, and assessed associations between gene expression and methylation for genome-wide significant CpGs (n=2802). RESULTS:In total for all analyses, high pesticide exposure was genome-wide significantly (false discovery rate P<0.05) associated with differential DNA methylation of 31 CpGs annotated to 29 genes. Twenty of these CpGs were found in subjects with airway obstruction. Several of the identified genes, for example, RYR1, ALLC, PTPRN2, LRRC3B, PAX2 and VTRNA2-1, are genes previously linked to either pesticide exposure or lung-related diseases. Seven out of 31 CpGs were associated with gene expression levels. CONCLUSIONS:We show for the first time that occupational exposure to pesticides is genome-wide associated with differential DNA methylation. Further research should reveal whether this differential methylation plays a role in the airway disease pathogenesis induced by pesticides.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
van der Plaat DA,de Jong K,de Vries M,van Diemen CC,Nedeljković I,Amin N,Kromhout H,Biobank-based Integrative Omics Study Consortium.,Vermeulen R,Postma DS,van Duijn CM,Boezen HM,Vonk JMdoi
10.1136/oemed-2017-104787subject
Has Abstractpub_date
2018-06-01 00:00:00pages
427-435issue
6eissn
1351-0711issn
1470-7926pii
oemed-2017-104787journal_volume
75pub_type
杂志文章abstract:OBJECTIVE:To investigate the risk of cancer associated with exposure to air pollution among bus drivers and tramway employees. METHODS:A retrospective cohort study of 18,174 bus drivers or tramway employees in Copenhagen in the period 1900-94. Data on employment were obtained from company files. Information on cancer ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.9.594
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To investigate associations between cancer incidence and exposure to coal tar pitch volatiles, asbestos, pot emissions (fluorides, sulphur dioxide), heat stress, and magnetic fields in workers from a Norwegian aluminium smelter that operated from 1914 to 1975. METHODS:Cancer incidence between 1953 and 1991 w...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.52.4.250
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:Prenatal occupational exposure to pesticides has been associated with male reproductive tract abnormalities. Little is known about the possible impact of non-occupational pesticide exposure on fetal and child development in the general population. Using data from a nationwide birth cohort, we aimed to assess...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-105801
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Assessment of exposure assessment to metal working fluids (MWF) has almost exclusively focused on inhalation exposure. AIMS:To assess levels of, and factors affecting, dermal and inhalation exposure to semi-synthetic MWF, and to identify suitable dermal exposure grouping schemes among metal workers for an e...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.015396
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents and Stoddard solvent during the period from 1 month before conception through the first trimester. METHODS:The study population included mothers...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100536
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To assess the effects of exposure to low concentrations of carbon monoxide (CO), as commonly measured in atmospheric urban air pollution and certain occupational environments, on exercise performance and myocardial perfusion in young healthy men, and the possible need for tighter restrictions on ambient conce...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/oem.56.8.535
更新日期:1999-08-01 00:00:00
abstract::The association between occupational exposure to airway irritants and the prevalence of chronic respiratory symptoms and level of lung function, and whether these associations were modified by airway hyperresponsiveness, smoking, and a history of allergy were studied in 668 workers from synthetic fibre plants. Respira...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.1.3
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVES:Poisson regression is now widely used in epidemiology, but researchers do not always evaluate the potential for bias in this method when the data are overdispersed. This study used simulated data to evaluate sources of overdispersion in public health surveillance data and compare alternative statistical mode...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.042887
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:To verify in vivo whether lung cinescintigraphy confirms the effect of asbestos on the patency of the smallest airways and on the efficiency of mucociliary clearance in asbestos cement workers. METHODS:39 male subjects were examined: 30 asbestos cement workers and nine workers never exposed to occupational ...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章
doi:10.1136/oem.53.9.628
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:To examine the association of immune cell number and function with occupational exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). METHODS:A cross sectional medical survey. The exposed participants were employed at two chemical plants between 1951 and 1972 in the manufactur...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.11.742
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective study was to examine the link between individual and ecological workplace social capital and the co-occurrence of adverse lifestyle risk factors such as smoking, heavy drinking, physical inactivity and overweight. METHODS:Data on 25 897 female and 5476 male public sector employees...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.042044
更新日期:2009-07-01 00:00:00
abstract:AIMS:To test whether (1) physically demanding work is less frequent for older than younger employees, and whether (2) the association of physically demanding work with decline of physical functioning is stronger for older employees than their younger counterparts. The gender differences in these associations were exami...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014035
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:The main objective was to study the acute vascular effects in the hands of normal healthy subjects of a complex vibration spectrum similar to that generated by many industrial hand held tools. The effects of repeated bouts of vibrations and alterations in the intensity of vibration were also studied. METHOD...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.10.663
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Between 2001 and 2010, six research groups conducted coordinated multiyear, prospective studies of carpal tunnel syndrome (CTS) incidence in US workers from various industries and collected detailed subject-level exposure information with follow-up symptom, physical examination, electrophysiological measures...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101365
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:To determine cell differential counts and the number of asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid obtained from patients with asbestosis, and to correlate the results with their survival. METHODS:The BAL cell differential counts and ABs from 91 patients with asbestosis were determined. The...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105606
更新日期:2019-10-01 00:00:00
abstract:AIMS:To correlate the prevalence of respiratory tract symptoms and diseases with dust and fibre exposure in the soft tissue industry in Germany. METHODS:Ambient monitoring was performed for inhalable, respirable dust and fibres in seven soft tissue producing factories. In 441 workers (72 controls, 90 moderate, 279 hig...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.12.830
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Standardised mortality ratios (SMRs) play an important role in the epidemiological literature, particularly in evaluations of occupational hazards. While some authors have argued that comparisons of SMRs should be avoided, many investigators find such analyses appealing particularly when data are sparse. For...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-100792
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of li...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104431
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:To study the risk of lung cancer in different subgroups of professional drivers in urban and rural areas of Sweden. METHODS:Information on occupation and geographical region was obtained from the Swedish census of 1970 and data on the incidence of lung cancer between 1971 and 1984 from the National Swedish ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.3.189
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVES:To estimate the prevalence and incidence of upper extremity musculoskeletal pain (UEMP) and related disability among office workers in Costa Rica, Nicaragua and Spain. METHODS:Data from the multinational Cultural and Psychosocial Influences on Disability (CUPID) study on 947 (93%) participants at baseline w...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-103327
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To investigate whether an increased risk of cardiovascular disease might be caused by increased arrhythmogeneity and by unfavourable changes in autonomic cardiac control the changes in the occurrence of premature complexes (PVCs) and in heart rate variability (HRV) were studied in subjects who started to wor...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.10.678
更新日期:2001-10-01 00:00:00
abstract::The "need for recovery scale" is suggested as an operationalisation for the measurement of (early symptoms of) fatigue at work. Definition of and background on the concept of need for recovery are briefly discussed. Details about scale construction are summarised. Correlations with other relevant measurement scales on...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.suppl_1.i3
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:Apparent increases in human male reproductive disorders, including low sperm production, may have occurred because of increased chemical exposure. Various glycol ether-based solvents have pronounced adverse effects on sperm production and male fertility in laboratory animals. The authors investigated the eff...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.023952
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Workers on dredgers and lighters on rivers are potentially exposed to a variety of substances. AIMS:To determine the internal load of heavy metals and arsenic as well as levels of cytogenetic markers in workers exposed to river silt aerosols. METHODS:One hundred exposed workers were examined up to eight ti...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.007146
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVES:To explore the use of 99technetiumm-hexamethyl propylene amine oxime single photon computed tomography (HMPAO-SPECT) of the brain as a means of detecting nervous tissue damage in divers and to determine if there is any correlation between brain image and a diver's history of diving or decompression illness (...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.4.247
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVES:Sick building syndrome (SBS) is described as a group of symptoms attributed to the physical environment of specific buildings. Isolating particular environmental features responsible for the symptoms has proved difficult. This study explores the role and significance of the physical and psychosocial work env...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.022889
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:There have been few studies of work history and mortality risks in medical radiation workers. We expanded by 11 years and more outcomes our previous study of mortality risks and work history, a proxy for radiation exposure. METHODS:Using Cox proportional hazards models, we estimated mortality risks accordin...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101859
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To study the effect on the incidence of cancer of exposure to chemicals handled in the leather tanning industry. MATERIALS AND METHODS:A case-control study was performed within a cohort of 2487 workers employed for at least six months during the period 1900-89 in three Swedish leather tanneries. 68 cancer ca...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.7.463
更新日期:1996-07-01 00:00:00
abstract:AIMS:This study examines the impact of work-related psychosocial and mechanical exposure on the development of low back pain (LBP) in the general working population. METHODS:A randomly drawn cohort from the general population in Norway aged 18-66 years was followed up for 3 years (n=12 550, response rate at baseline=6...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101116
更新日期:2013-05-01 00:00:00
abstract:AIMS:To examine the hypothesis that people with benign pleural disease or asbestosis have an increased risk of malignant mesothelioma beyond that attributable to their degree of asbestos exposure. METHODS:Former workers and residents of the crocidolite mining and milling town of Wittenoom are participating in a cancer...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.018531
更新日期:2005-10-01 00:00:00