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Occupation and bladder cancer in a population-based case-control study in Northern New England.

Abstract：

OBJECTIVES:We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk. METHODS:Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial carcinoma of the bladder in 2001-2004, and from 1402 population controls. Unconditional logistic regression was used to calculate ORs and 95% CIs, adjusted for demographic factors, smoking and employment in other high-risk occupations. RESULTS:Male precision metalworkers and metalworking/plasticworking machine operators had significantly elevated risks and significant trends in risk with duration of employment (precision metalworkers: OR 2.2, 95% CI 1.4 to 3.4, p(trend) = 0.0065; metalworking/plasticworking machine operators: OR 1.6, 95% CI 1.01 to 2.6, p(trend) = 0.047). Other occupations/industries for which risk increased significantly with duration of employment included: for men, textile machine operators, mechanics/repairers, automobile mechanics, plumbers, computer systems analysts, information clerks, and landscape industry workers; for women, service occupations, health services, cleaning and building services, management-related occupations, electronic components manufacturing and transportation equipment manufacturing. Men reporting use of metalworking fluids (MWF) had a significantly elevated bladder cancer risk (OR 1.7, 95% CI 1.1 to 2.5). CONCLUSIONS:Our findings support the hypothesis that some component(s) of MWF may be carcinogenic to the bladder. Our results also corroborate many other previously reported associations between bladder cancer risk and various occupations. More detailed analyses using information from the study's job-specific questionnaires may help to identify MWF components that may be carcinogenic, and other bladder carcinogens associated with a variety of occupations.

journal_name

Occup Environ Med

journal_title

Occupational and environmental medicine

authors

Colt JS,Karagas MR,Schwenn M,Baris D,Johnson A,Stewart P,Verrill C,Moore LE,Lubin J,Ward MH,Samanic C,Rothman N,Cantor KP,Beane Freeman LE,Schned A,Cherala S,Silverman DT

doi

10.1136/oem.2009.052571

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

239-49

issue

eissn

1351-0711

issn

1470-7926

pii

oem.2009.052571

journal_volume

pub_type

杂志文章,多中心研究

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Occupation and bladder cancer in a population-based case-control study in Northern New England.