Abstract:
OBJECTIVE:This study was undertaken to assess whether contaminated personal clothing worn beneath a coverall (normal workwear) is a source of potentially significant dermal exposure to polycyclic aromatic hydrocarbons (PAHs) in coal liquefaction workers. METHODS:An intervention study was conducted over a two week period involving 10 workers that reflected the range of activities performed at the factory. A cross over design was used to examine the influence of normal workwear (personal clothing worn beneath a coverall) and intervention workwear (new coverall, shirt, trousers, underwear, socks, and boots) upon excretion of urinary 1-hydroxypyrene (1-OHP) and skin pad deposition of pyrene. RESULTS:The impact of intervention was noted in three ways: (1) A notable reduction (55%) in the mass of 1-OHP excreted on the first day of the intervention phase was found. The median reduction in mass excreted (22.7 nmol) was significant from zero at the 5% level; (95% confidence interval (95% CI) 9.5-40.8 nmol). (2) A notable reduction (82%) in skin pad deposition of pyrene on the first day of the intervention phase was found. The median reduction of 13.20 ng.cm-2 was significant from zero at the 5% level; (95% CI 7.3-26.4 ng.cm-2). (3) About a 50% reduction in 1-OHP concentration over the working week occurred during the intervention phase; an increase of 2.07 mumol/mol creatinine was found from the start to the end of the work period during the intervention phase compared with an increase of 4.06 mumol/mol creatinine during the normal phase. This reduction was not significant at the 5% level. CONCLUSION:The results indicate that on the first day of the working week investigated, significant reductions in absorbtion (as measured by excretion of urinary 1-OHP) and deposition of PAHs (as measured by skin pad deposition of pyrene) can be effected by improvements in workwear policy. The impact of the improved workwear regimen was also detected by reduction in spot urinary 1-OHP concentrations, although this effect was less pronounced. One implication of the findings is that exposure to PAHs may arise from workers' own contaminated personal clothing. As a consequence of this study an improved workwear policy has been implemented at the factory.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Quinlan R,Kowalczyk G,Gardiner K,Calvert Idoi
10.1136/oem.52.9.600subject
Has Abstractpub_date
1995-09-01 00:00:00pages
600-5issue
9eissn
1351-0711issn
1470-7926journal_volume
52pub_type
临床试验,杂志文章,随机对照试验abstract:AIMS:To correlate the prevalence of respiratory tract symptoms and diseases with dust and fibre exposure in the soft tissue industry in Germany. METHODS:Ambient monitoring was performed for inhalable, respirable dust and fibres in seven soft tissue producing factories. In 441 workers (72 controls, 90 moderate, 279 hig...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.12.830
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Previous analyses of cataract in radiation-exposed populations have assessed relative risk; radiogenic excess additive risk (EAR), arguably of more public health importance, has not been estimated. Previous analysis of a large prospective cohort of US radiologic technologists (USRT) quantified excess relativ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-105902
更新日期:2020-01-01 00:00:00
abstract:AIMS:To examine the hypothesis that people with benign pleural disease or asbestosis have an increased risk of malignant mesothelioma beyond that attributable to their degree of asbestos exposure. METHODS:Former workers and residents of the crocidolite mining and milling town of Wittenoom are participating in a cancer...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.018531
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVES:To elucidate factors contributing to hard metal asthma, the entire workforce of a corporation producing hard metal tools (n = 703) was examined. METHODS:The variables evaluated were the atopy reflected by immunoglobulin E (IgE) antibody against mite allergen, history of exposure to hard metal, smoking, conc...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.3.188
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVES:The chronic effects of urban air pollution are not well known. The authors' aim was to investigate the association between the prevalence and new onset of chronic bronchitis and urban air pollution. METHODS:Subjects from the general population randomly selected for the European Community Respiratory Health ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2006.027995
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVES:To describe the relation with age of risk of reported injury after a fall among women at work in two countries, the United Kingdom and Sweden, with particular emphasis on fractures, and to interpret these data. METHODS:Rates of accidents compiled under the national reporting regulations of each country duri...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.11.785
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:Benzene is an established animal and human carcinogen. The mechanism of benzene toxicity, particularly its leukaemogenic effect, is not fully understood. The modified base 8-hydroxy-deoxyguanosine (8-OHdG) is a sensitive marker of the DNA damage due to hydroxyl radical attack at the C8 of guanine. This damag...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.11.739
更新日期:1994-11-01 00:00:00
abstract::This systematic review was conducted to help clarify the effect of lifting at work on pregnancy outcome, by focusing on specific exposure categories. A search in Medline and Embase identified 51 articles reporting association of spontaneous abortion (SA), preterm delivery (PTD) or small-for-gestational-age (SGA) infan...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oemed-2019-106334
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:There is an ongoing debate regarding environmental health risks of exposures to dust and microbial agents from livestock farming in the Netherlands. The aims of the study were (1) to investigate associations between indicators of air pollution from livestock farms and asthma, allergic rhinitis and chronic ob...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101485
更新日期:2014-02-01 00:00:00
abstract::Asbestos exposure is associated with mesothelioma and cancer of the lung, larynx and ovary. However, the association between asbestos exposure and colorectal cancer is controversial despite several systematic reviews of the literature, including a number of meta-analyses. We performed a systematic review and meta-anal...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oemed-2019-105735
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To investigate further whether inorganic lead is a carcinogen among adults, or associated with increased blood pressure and kidney damage, via a large mortality study. METHODS:We conducted internal analyses via Cox regression of mortality in three cohorts of lead-exposed workers with blood lead (BL) data (U...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104311
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To determine cell differential counts and the number of asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid obtained from patients with asbestosis, and to correlate the results with their survival. METHODS:The BAL cell differential counts and ABs from 91 patients with asbestosis were determined. The...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105606
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:Sick building syndrome (SBS) is described as a group of symptoms attributed to the physical environment of specific buildings. Isolating particular environmental features responsible for the symptoms has proved difficult. This study explores the role and significance of the physical and psychosocial work env...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2005.022889
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Office computer workers are at increased risk for neck/upper extremity (UE) musculoskeletal pain. METHODS:A seven-month office ergonomic intervention study evaluated the effect of two engineering controls plus training on neck/UE pain and mechanical exposures in 113 computer workers, including a 3-month fol...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2014-102160
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to determine whether self-reported occupational exposure to cleaning/disinfecting agents in hospital workers is accurate, in comparison to expert assessment, taken to be the gold standard. METHODS:In the Epidemiological Study of the Genetics and Environment of Asthma (EGEA), partici...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.061671
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:Compare rates of medical insurance claims for musculoskeletal disorders (MSD) between workers in a construction trade and a general worker population to determine if higher physical exposures in construction lead to higher rates of claims on personal medical insurance. METHODS:Health insurance claims betwee...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102313
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To describe the small area system developed in Finland. To illustrate the use of the system with analyses of incidence of lung cancer around an asbestos mine. To compare the performance of different spatial statistical models when applied to sparse data. METHODS:In the small area system, cancer and populati...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.5.315
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach c...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2016-103597
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To explore the healthy worker survivor effect (HWSE) in a study of Vermont granite workers by distinguishing "prevalent" from "incident" hires based on date of hire before or after the start of follow-up. METHODS:Records of workers between 1950 and 1982 were obtained from a medical surveillance programme. Pr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2006.031369
更新日期:2007-10-01 00:00:00
abstract::Worldwide, millions of office workers use a computer. Reports of adverse health effects due to computer use have received considerable media attention. This systematic review summarises the evidence for a relationship between the duration of work time spent using the computer and the incidence of hand-arm and neck-sho...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
doi:10.1136/oem.2006.026468
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:This study evaluated the determinants of high fractional exhaled nitric oxide (FeNO; >50 ppb) and serial changes in FeNO over a 24-hour period in spice mill workers at risk of work-related allergic respiratory disease and asthma. METHODS:A cross-sectional study of 150 workers used European Community Respira...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-103005
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:We have studied cross-shift respiratory responses of several individual bioaerosol components of the dust in the grain and feed industry in Norway. METHODS:Cross-shift changes in lung function and nasal congestion, as well as in respiratory and systemic symptoms of 56 exposed workers and 36 referents, were r...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2015-103438
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:The main objective was to study the acute vascular effects in the hands of normal healthy subjects of a complex vibration spectrum similar to that generated by many industrial hand held tools. The effects of repeated bouts of vibrations and alterations in the intensity of vibration were also studied. METHOD...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.10.663
更新日期:1996-10-01 00:00:00
abstract::Lymphohaematopoeitic cancer mortality was examined among 4417 workers at a chemical plant by cumulative and peak benzene exposure. There was little evidence of increasing risk with increasing cumulative exposure for all leukaemias or acute non-lymphocytic leukaemias (ANL), or the other lymphohaematopoeitic cancers wit...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.9.676
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Serious delayed neuropsychological sequelae may complicate carbon monoxide intoxication. The existence of minor manifestations, especially memory disturbances, is not well documented. AIMS:To study several memory functions after carbon monoxide intoxication. METHODS:In a prospective study, 32 poisoned pati...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.3.212
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS:Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classificat...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oemed-2018-105131
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:Prenatal occupational exposure to pesticides has been associated with male reproductive tract abnormalities. Little is known about the possible impact of non-occupational pesticide exposure on fetal and child development in the general population. Using data from a nationwide birth cohort, we aimed to assess...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-105801
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:Psychosocial work characteristics have been prospectively associated with depressive symptoms. However, methodological limitations have raised questions regarding causality. It is also unclear to what extent depressive symptoms affect the experience of the psychosocial work environment. We examined contempor...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2018-105450
更新日期:2019-07-01 00:00:00
abstract::Urinary N-acetyl-beta-D-glucosaminidase (NAG) had been shown to be a useful early marker of renal injury. In workers exposed to lead it seems to be the only early marker but the dose response and dose effect relations are weak. Furthermore, the significance and underlying mechanism of increased urinary NAG activity is...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.2.125
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:Introduced in the UK in 2010, the fit note was designed to address the problem of long-term sickness absence. We explored (1) associations between demographic variables and fit note receipt, 'maybe fit' use and long-term conditions, (2) whether individuals with long-term conditions receive more fit notes and...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106035
更新日期:2020-06-01 00:00:00