Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis.

Abstract:

OBJECTIVE:To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS:Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene. RESULTS:Increased mortality from non-Hodgkin's lymphoma (NHL) was associated with the mean level of exposure to styrene in air (relative risk (RR) 2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative styrene exposure. Similar associations with mean exposure were observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per 100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09). Oesophageal cancer mortality was also associated with cumulative styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31). No other cancer, including lung cancer, was associated with any indicator of styrene exposure. CONCLUSION:This reanalysis does not substantially change the conclusions of the original study with respect to NHL or lung cancer but new evidence concerning cancers of the oesophagus and pancreas merits further investigation.

journal_name

Occup Environ Med

authors

Loomis D,Guha N,Kogevinas M,Fontana V,Gennaro V,Kolstad HA,McElvenny DM,Sallmén M,Saracci R

doi

10.1136/oemed-2018-105131

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

157-162

issue

3

eissn

1351-0711

issn

1470-7926

pii

oemed-2018-105131

journal_volume

76

pub_type

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