Abstract:
OBJECTIVES:To investigate the occurrence of work related respiratory symptoms and to assess the effect of atopy in a group of trainee bakers. METHODS:A prospective study of work related respiratory symptoms among 125 trainee bakers who were investigated with a questionnaire plus skin prick test with wheat flour and alpha-amylase allergens at baseline and then after 6, 18, and 30 months. RESULTS:At the baseline examination, four students (3.2%) complained of respiratory symptoms (cough and rhinitis) when working with flours and four were skin positive to wheat flour or alpha-amylase. The incidence of work related respiratory symptoms was 3.4% at 6 months, and the cumulative incidence was 4.8% and 9.0% at 18 and 30 months, respectively. The incidence of skin sensitisation to occupational allergens was 4.6% at 6 months and the cumulative incidence was 4.6% at 18 months and 10.1% at 30 months. The generalised estimating equation approach to longitudinal data showed that work related respiratory symptoms in the study population was significantly associated with a personal history of allergic disease (odds ratio (OR) 5.8, 95% confidence interval (95% CI) 1.8 to 18.2) and skin sensitisation to wheat flour or alpha-amylase (OR 4.3, 95% CI 1.2 to 14.9). Atopy based on prick test was not related to the occurrence of work related respiratory symptoms over time (OR 1.1, 95% CI 0.3 to 3.8). CONCLUSIONS:Personal history of allergic disease is a predisposing factor for the development of symptoms caused by exposure to wheat flour and may be a criterion of unsuitability for starting a career as a baker. Atopy based on the skin prick test is useful for identifying subjects with allergic disease, but should not be used to exclude non-symptomatic atopic people from bakery work.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
De Zotti R,Bovenzi Mdoi
10.1136/oem.57.1.58subject
Has Abstractpub_date
2000-01-01 00:00:00pages
58-61issue
1eissn
1351-0711issn
1470-7926journal_volume
57pub_type
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journal_title:Occupational and environmental medicine
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journal_title:Occupational and environmental medicine
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journal_title:Occupational and environmental medicine
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doi:10.1136/oem.2008.041582
更新日期:2009-10-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00