Cancer surveillance among workers in plastics and rubber manufacturing in Ontario, Canada.

Abstract:

OBJECTIVE:Occupational exposure to agents in plastics and rubber manufacturing has been associated with elevated risk of certain cancers. We sought to evaluate cancer risk among workers employed in occupations and industries with these exposures as part of an ongoing surveillance programme in Ontario, Canada. METHODS:The Occupational Disease Surveillance System (ODSS) cohort was established using workers' compensation claims data and includes 2.18 million workers employed from 1983 to 2014. Workers were followed for site-specific cancer diagnoses in the Ontario Cancer Registry through 2016. Cox proportional hazard models were used to estimate adjusted HR and 95% CI. RESULTS:We identified 81 127 workers employed in plastics and rubber manufacturing industries or materials processing and product fabricating occupations. Compared with all other women in the ODSS, those in materials processing occupations had an elevated rate of lung cancer (HR 1.38, 95% CI 1.20 to 1.58) that was not observed among men. An elevated rate of breast cancer was observed among female labourers (HR 1.36, 95% CI 1.01 to 1.82) and moulders (HR 1.47, 95% CI 0.91 to 2.37) in plastics and rubber product fabricating occupations. Overall, elevated rates were observed for oesophageal, liver, stomach, prostate and kidney cancer in job-specific subgroups, including mixing and blending, bonding and cementing, and labouring. There was little evidence of association for lymphatic or haematopoietic cancers. CONCLUSIONS:Findings for lung and breast cancer in women are consistent with other studies and warrant further attention in Ontario. Given the relatively young age at end of follow-up, surveillance in these workers should continue as the cohort ages.

journal_name

Occup Environ Med

authors

DeBono NL,Logar-Henderson C,Warden H,Shakik S,Dakouo M,MacLeod J,Demers PA

doi

10.1136/oemed-2020-106581

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

847-856

issue

12

eissn

1351-0711

issn

1470-7926

pii

oemed-2020-106581

journal_volume

77

pub_type

杂志文章
  • Reactive airways dysfunction syndrome caused by bromochlorodifluoromethane from fire extinguishers.

    abstract::Although the neurological and cardiovascular effects of Freons have been extensively described, the respiratory effects have been less well documented. We report four cases of occupational asthma following accidental exposure to bromochlorodifluoromethane (Halon 1211) due to release of the contents of a fire extinguis...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2003.009837

    authors: Matrat M,Laurence MF,Iwatsubo Y,Hubert C,Joly N,Legrand-Cattan K,L'Huillier JP,Villemain C,Pairon JC

    更新日期:2004-08-01 00:00:00

  • Lung cancer risk in welders and foundry workers with a history of heavy smoking in the USA: The National Lung Screening Trial.

    abstract:OBJECTIVES:Foundry work is a risk factor for lung cancer; however, the association with welding is unclear, as smoking is common among metalworkers and may mask the relationship. We evaluated whether history of welding and foundry work, independently and jointly, and employment duration were associated with lung cancer...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/oemed-2016-104168

    authors: Wong JYY,Bassig BA,Seow WJ,Hu W,Ji BT,Blair A,Silverman DT,Lan Q

    更新日期:2017-06-01 00:00:00

  • Sperm count and chromatin structure in men exposed to inorganic lead: lowest adverse effect levels.

    abstract:OBJECTIVES:To obtain knowledge on male reproductive toxicity of inorganic lead at current European exposure levels and to establish lowest adverse effect levels, if any. METHODS:A cross sectional survey of the semen of 503 men employed by 10 companies was conducted in the United Kingdom, Italy, and Belgium. The mean b...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.59.4.234

    authors: Bonde JP,Joffe M,Apostoli P,Dale A,Kiss P,Spano M,Caruso F,Giwercman A,Bisanti L,Porru S,Vanhoorne M,Comhaire F,Zschiesche W

    更新日期:2002-04-01 00:00:00

  • Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis.

    abstract:OBJECTIVE:Diazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk. We used updated diazinon exposure and cancer incidence inform...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2014-102728

    authors: Jones RR,Barone-Adesi F,Koutros S,Lerro CC,Blair A,Lubin J,Heltshe SL,Hoppin JA,Alavanja MC,Beane Freeman LE

    更新日期:2015-07-01 00:00:00

  • Upper extremity musculoskeletal pain among office workers in three Spanish-speaking countries: findings from the CUPID study.

    abstract:OBJECTIVES:To estimate the prevalence and incidence of upper extremity musculoskeletal pain (UEMP) and related disability among office workers in Costa Rica, Nicaragua and Spain. METHODS:Data from the multinational Cultural and Psychosocial Influences on Disability (CUPID) study on 947 (93%) participants at baseline w...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2015-103327

    authors: Campos-Fumero A,Delclos GL,Douphrate DI,Felknor SA,Vargas-Prada S,Serra C,Coggon D,Gimeno Ruiz de Porras D

    更新日期:2016-06-01 00:00:00

  • Developments in reproductive risk management.

    abstract::Internationally, the debate on aims for occupational health policy is expanding its horizons. Included among the issues are not only concerns about safety for workers, but also for their progeny. Equality among the sexes is also assuming a prominent position. In several countries, existing and proposed legislation alr...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,评审

    doi:10.1136/oem.52.5.294

    authors: Stijkel A,van Dijk FJ

    更新日期:1995-05-01 00:00:00

  • Predictive value of work-related self-efficacy change on RTW for employees with common mental disorders.

    abstract::To improve interventions that aim to promote return to work (RTW) of workers with common mental disorders (CMD), insight into modifiable predictors of RTW is needed. This study tested the predictive value of self-efficacy change for RTW in addition to preintervention levels of self-efficacy. RTW self-efficacy was meas...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2016-104039

    authors: Lagerveld SE,Brenninkmeijer V,Blonk RW,Twisk J,Schaufeli WB

    更新日期:2017-05-01 00:00:00

  • Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators.

    abstract:OBJECTIVES:Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of li...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2017-104431

    authors: Lerro CC,Beane Freeman LE,DellaValle CT,Kibriya MG,Aschebrook-Kilfoy B,Jasmine F,Koutros S,Parks CG,Sandler DP,Alavanja MCR,Hofmann JN,Ward MH

    更新日期:2018-02-01 00:00:00

  • A retrospective assessment of occupational noise exposures for a longitudinal epidemiological study.

    abstract:OBJECTIVES:Chronic exposure to high levels of noise may be associated with increased risk of cardiovascular disease. We therefore undertook a quantitative retrospective exposure assessment using predictive statistical modelling to estimate historical exposures to noise among a cohort of 27,499 sawmill workers as part o...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.2008.040881

    authors: Davies HW,Teschke K,Kennedy SM,Hodgson MR,Demers PA

    更新日期:2009-06-01 00:00:00

  • Air samples versus biomarkers for epidemiology.

    abstract:BACKGROUND:It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies. METHODS AND RESULTS:Biomarkers were classified according to their position in the exposure-disease continuum-that is, parent compound, reactive intermediate, s...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2004.013102

    authors: Lin YS,Kupper LL,Rappaport SM

    更新日期:2005-11-01 00:00:00

  • Can strenuous leisure time physical activity prevent psychological complaints in a working population?

    abstract:AIMS:To investigate the longitudinal relation between strenuous leisure time physical activity and psychological complaints (depression and emotional exhaustion) in a Dutch working population in order to find evidence for the preventive role of physical activity in the development of psychological complaints. METHODS:...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.2004.017541

    authors: Bernaards CM,Jans MP,van den Heuvel SG,Hendriksen IJ,Houtman IL,Bongers PM

    更新日期:2006-01-01 00:00:00

  • Effects on the nervous system in different groups of workers exposed to aluminium.

    abstract:OBJECTIVE:To investigate possible neurotoxic effects in groups of aluminium pot room and foundry workers, aluminium welders, and a small group of workers exposed to aluminium in the production of flake powder. METHODS:Exposure to aluminium was evaluated with aluminium concentrations in blood and urine as well as a que...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.58.7.453

    authors: Iregren A,Sjögren B,Gustafsson K,Hagman M,Nylén L,Frech W,Andersson M,Ljunggren KG,Wennberg A

    更新日期:2001-07-01 00:00:00

  • Impact of depressive symptoms on worklife expectancy: a longitudinal study on Danish employees.

    abstract:OBJECTIVE:Depressive symptoms are associated with sickness absence, work disability and unemployment, but little is known about worklife expectancy (WLE). This study investigates the impact of depressive symptoms on the WLE of a large sample of Danish employees. METHODS:We used occupational health survey data of 11 96...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2019-105961

    authors: Pedersen J,Thorsen SV,Andersen MF,Hanvold TN,Schlünssen V,Bültmann U

    更新日期:2019-11-01 00:00:00

  • Risk of cancer among paper recycling workers.

    abstract:OBJECTIVES:Studies in traditional paper mills have indicated an excess cancer risk, and mutagenic compounds have been identified in the industry. No studies have reported on risk of cancer in paper recycling. Therefore the cancer incidence in Danish paper recycling mills was investigated. METHODS:5377 employees in fiv...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.54.10.729

    authors: Rix BA,Villadsen E,Engholm G,Lynge E

    更新日期:1997-10-01 00:00:00

  • The impact of chronotype on melatonin levels among shift workers.

    abstract:OBJECTIVES:The association between shift work and cancer, which is thought to be mediated by effects on circulating melatonin levels, may be modified by chronotype (ie, the inherent preference for activity in the morning or the evening); however, few studies have examined the potential impact of chronotype on the carci...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2013-101730

    authors: Bhatti P,Mirick DK,Davis S

    更新日期:2014-03-01 00:00:00

  • Bronchoalveolar cell differential count and the number of asbestos bodies correlate with survival in patients with asbestosis.

    abstract:OBJECTIVES:To determine cell differential counts and the number of asbestos bodies (ABs) in bronchoalveolar lavage (BAL) fluid obtained from patients with asbestosis, and to correlate the results with their survival. METHODS:The BAL cell differential counts and ABs from 91 patients with asbestosis were determined. The...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2018-105606

    authors: Keskitalo E,Varis L,Bloigu R,Kaarteenaho R

    更新日期:2019-10-01 00:00:00

  • Respiratory symptoms, lung function, and nasal cellularity in Indonesian wood workers: a dose-response analysis.

    abstract:OBJECTIVES:It was hypothesised that inflammation plays a dominant part in the respiratory effects of exposure to wood dust. The purpose of this study was to relate the nasal inflammatory responses of workers exposed to meranti wood dust to (a) levels of exposure, (b) respiratory symptoms and (c) respiratory function. ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.59.5.338

    authors: Borm PJ,Jetten M,Hidayat S,van de Burgh N,Leunissen P,Kant I,Houba R,Soeprapto H

    更新日期:2002-05-01 00:00:00

  • Mortality and cancer morbidity in workers from an aluminium smelter with prebaked carbon anodes--Part II: Cancer morbidity.

    abstract:OBJECTIVE:To investigate associations between cancer incidence and exposure to coal tar pitch volatiles, asbestos, pot emissions (fluorides, sulphur dioxide), heat stress, and magnetic fields in workers from a Norwegian aluminium smelter that operated from 1914 to 1975. METHODS:Cancer incidence between 1953 and 1991 w...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.52.4.250

    authors: Rønneberg A,Andersen A

    更新日期:1995-04-01 00:00:00

  • Occupational exposure to crystalline silica and gastric cancer: a systematic review and meta-analysis.

    abstract::Crystalline silica is a widely used industrial material that is readily available worldwide, and is one of the most common types of particulate mineral pollutants. It has been classified as a group 1 human carcinogen of the respiratory system; however, whether it is linked to gastric cancer remains uncertain. We condu...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/oemed-2016-103552

    authors: Lee W,Ahn YS,Lee S,Song BM,Hong S,Yoon JH

    更新日期:2016-11-01 00:00:00

  • Daily concentrations of air pollution and plasma fibrinogen in London.

    abstract:OBJECTIVES:The reason for the association between air pollution and risk of cardiovascular diseases is unknown. The hypothesis was examined that daily concentrations of air pollution are associated with daily concentrations of fibrinogen, a risk factor for cardiovascular disease. METHODS:Data on concentrations of plas...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.57.12.818

    authors: Pekkanen J,Brunner EJ,Anderson HR,Tiittanen P,Atkinson RW

    更新日期:2000-12-01 00:00:00

  • Self reported rate of occupational asthma in Sweden 1990-2.

    abstract:OBJECTIVES:To estimate the annual rates of self reported occupational asthma in different occupational groups in Sweden. METHODS:All claims of occupational asthma 1990-2 in the Swedish register of reported occupational diseases were classified according to occupation. The number of people employed in each occupational...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.53.11.757

    authors: Torén K

    更新日期:1996-11-01 00:00:00

  • Correlation between 99Tcm-HMPAO-SPECT brain image and a history of decompression illness or extent of diving experience in commercial divers.

    abstract:OBJECTIVES:To explore the use of 99technetiumm-hexamethyl propylene amine oxime single photon computed tomography (HMPAO-SPECT) of the brain as a means of detecting nervous tissue damage in divers and to determine if there is any correlation between brain image and a diver's history of diving or decompression illness (...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.54.4.247

    authors: Shields TG,Duff PM,Evans SA,Gemmell HG,Sharp PF,Smith FW,Staff RT,Wilcock SE

    更新日期:1997-04-01 00:00:00

  • Semen quality and sex hormones among organic and traditional Danish farmers. ASCLEPIOS Study Group.

    abstract:OBJECTIVES:To confirm or refute the hypothesis that organic farmers have higher sperm concentrations than traditional farmers. METHODS:Traditional and organic farmers were selected randomly from central registers, and 171 traditional farmers and 85 organic farmers delivered one semen sample before the start of the spr...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.56.2.139

    authors: Larsen SB,Spanò M,Giwercman A,Bonde JP

    更新日期:1999-02-01 00:00:00

  • Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk.

    abstract:BACKGROUND:The pathogenesis of cataract is influenced by a number of factors including oxidative stress. Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors. It is important for detoxification of xenobiotics in order to protect tissues from oxidative damage...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2005.022343

    authors: Saadat M,Farvardin-Jahromi M

    更新日期:2006-07-01 00:00:00

  • Rotating night shift work and risk of multiple sclerosis in the Nurses' Health Studies.

    abstract:OBJECTIVES:Night shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses' Health Study (NHS) and NHSII. METHODS:A total of ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oemed-2019-106016

    authors: Papantoniou K,Massa J,Devore E,Munger KL,Chitnis T,Ascherio A,Schernhammer ES

    更新日期:2019-10-01 00:00:00

  • Point-of-sale glass bottle recycling: indoor airborne exposures and symptoms among employees.

    abstract:AIMS:To assess the impact of newly introduced point-of-sale glass bottle recycling on indoor air quality and employee health. METHODS:Airborne exposures and both chronic and acute respiratory and somatic symptoms were surveyed among 226 employees at 36 randomly selected liquor stores with bottle recycling and in-house...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.2003.009753

    authors: Kennedy SM,Copes R,Bartlett KH,Brauer M

    更新日期:2004-07-01 00:00:00

  • Airway inflammation in aluminium potroom asthma.

    abstract:AIMS:To examine whether asthma induced by exposure to aluminium potroom emissions (potroom asthma) is associated with inflammatory changes in the airways. METHODS:Bronchial biopsy specimens from 20 asthmatic workers (8 non-smokers and 12 smokers), 15 healthy workers (8 non-smokers and 7 smokers), and 10 non-exposed co...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.2003.011627

    authors: Sjåheim T,Halstensen TS,Lund MB,Bjørtuft Ø,Drabløs PA,Malterud D,Kongerud J

    更新日期:2004-09-01 00:00:00

  • Cancer and occupational exposure to inorganic lead compounds: a meta-analysis of published data.

    abstract:OBJECTIVES:To review and summarise the epidemiological evidence on the carcinogenicity of occupational exposure to inorganic lead. METHODS:Case-control and cohort studies were reviewed and combined for meta-analysis. Fixed and random effect methods were used to estimate the summary effects. RESULTS:The combined resul...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,meta分析

    doi:10.1136/oem.52.2.73

    authors: Fu H,Boffetta P

    更新日期:1995-02-01 00:00:00

  • Influenza immunisation: attitudes and beliefs of UK healthcare workers.

    abstract:AIM:To explore attitudes to influenza immunisation and rates of uptake among staff working in acute hospitals in the UK. METHOD:A cross-sectional survey of 11,670 healthcare workers in six UK hospitals was carried out using a postal questionnaire. RESULTS:Among 6302 responders (54% of those mailed), 19% had taken up ...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1136/oem.2005.023564

    authors: Smedley J,Poole J,Waclawski E,Stevens A,Harrison J,Watson J,Hayward A,Coggon D

    更新日期:2007-04-01 00:00:00

  • Seasonal changes in ambulatory blood pressure in employees under different indoor temperatures.

    abstract:OBJECTIVE:The effect of indoor temperature control on summer and winter ambulatory blood pressure levels at work was studied. METHOD:Ambulatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) were monitored once in summer and once in winter in 101 healthy normotensive subjects aged 28-63 years, engage...

    journal_title:Occupational and environmental medicine

    pub_type: 杂志文章

    doi:10.1136/oem.52.11.715

    authors: Kristal-Boneh E,Harari G,Green MS,Ribak J

    更新日期:1995-11-01 00:00:00