Abstract:
OBJECTIVES:Epidemiological studies have shown inconsistent effects on immunological parameters in subjects exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this study we investigated changes in humoral immunity and prevalence of atopic diseases among workers from a Dutch historical cohort occupationally exposed to chlorophenoxy herbicides and contaminants including TCDD. METHODS:45 workers who had been exposed to high levels of TCDD in the past and 108 non-exposed workers (39 from the same factory as the exposed subjects (internal control group) and 69 from a comparable factory but without TCDD exposure (external control group)) were included in the study. Blood immunoglobulin (Ig) and complement factor (C) concentrations and specific IgE antibodies to a panel of common allergens were measured using quantitative nephelometry or ELISA. TCDD plasma levels were measured and back-extrapolated to the time of last exposure (TCDDmax) using a one-compartment first order kinetic model. RESULTS:A borderline significant negative association between both current and predicted TCDD levels and C4 was found in multivariate analyses (β = -0.020; 95% CI = -0.040-0.010 and β = -0.020; 95% CI = -0.030-0.00, respectively). History of eczema was significantly associated with current TCDD levels in both crude (OR = 1.5; 95% CI = 1.03-2.2) and adjusted models (OR = 1.7; 95% CI = 1.08-2.7). CONCLUSIONS:Our results do not support an association between TCDD exposure and markers of humoral immunity except possibly C4. Interestingly, decreased levels of C4 have been linked to lymphoma risk, which provides some support to the putative link between TCDD and non-Hodgkin lymphoma.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Saberi Hosnijeh F,Boers D,Portengen L,Bueno-de-Mesquita HB,Heederik D,Vermeulen Rdoi
10.1136/oem.2010.058016subject
Has Abstractpub_date
2011-06-01 00:00:00pages
419-24issue
6eissn
1351-0711issn
1470-7926pii
oem.2010.058016journal_volume
68pub_type
杂志文章abstract::Fluorocarbons are widely used in industry, and manifestations of inhalation toxicity include polymer fume fever, reactive airways dysfunction, and bronchospasm. Only seven cases of alveolitis occurring acutely after inhalation have been reported. This paper presents four cases of toxic pneumonitis due to direct inhala...
journal_title:Occupational and environmental medicine
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abstract::The International Agency for Research on Cancer has classified occupational exposure as a painter as 'carcinogenic to humans', largely based on increased risks of bladder and lung cancer. A meta-analysis, including more than 2900 incident cases or deaths from bladder cancer among painters reported in 41 cohort (n=2), ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,评审
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abstract:OBJECTIVES:To investigate the sources of high concentrations of particles of < 10 microns diameter (PM10) in classrooms, observed in a previous study on childhood exposure to PM10, and to study the correlation between classroom and outdoor concentrations of mass and elements of PM10. METHODS:Measurements of PM10 were ...
journal_title:Occupational and environmental medicine
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doi:10.1136/oem.56.7.482
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journal_title:Occupational and environmental medicine
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doi:10.1136/oem.58.1.19
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abstract:OBJECTIVES:The fit note, introduced in England, Wales and Scotland in 2010, was designed to change radically the sickness certification process from advising individuals on their inability to work to advising them on what they could do if work could be adapted. Our review aimed to evaluate the following: (1) Is the 'ma...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2017-104730
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abstract:AIMS:To evaluate an epidemiological approach to a national noise hazard surveillance strategy, and report current exposure levels in the Danish workplace. METHODS:A study base of 840 companies in 10 selected high risk industries in the largest county in Denmark was identified from a national register. Noise exposure w...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.012757
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abstract:OBJECTIVES:A hospital based case-control study was conducted between 1992 and 1993 in the province of Brescia, a highly industrialised area in northern Italy, to evaluate occupational risk factors of bladder cancer. METHODS:The study evaluated 355 histologically confirmed cases of bladder cancer (275 men, 80 women) an...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.1.6
更新日期:1996-01-01 00:00:00
abstract:AIMS:To investigate the concentration of urinary 8-hydroxydeoxyguanosine (8-OHdG) among electroplating workers in Taiwan. METHODS:Fifty workers were selected from five chromium (Cr) electroplating plants in central Taiwan. The 20 control subjects were office workers with no previous exposure to Cr. Urinary 8-OHdG conc...
journal_title:Occupational and environmental medicine
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doi:10.1136/oem.60.8.590
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:To obtain knowledge about the use and distribution of hazardous chemicals in Danish industry. This knowledge is used to regulate the occupational environment and prevent hazardous exposure. METHODS:A national survey on the use of chemicals was carried out in 1989 in a stratified sample of 1448 Danish busine...
journal_title:Occupational and environmental medicine
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doi:10.1136/oem.52.7.454
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.6.427
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:For the retrospective study of environment and health linkages biomarkers of exposure are required. Polychlorinated dibenzo-dioxins and furans (PCDD/F) and polychlorinated biphenyls (PCBs) have been useful markers in some settings. This is the first study of PCDD/F body burden in a population based sample fr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.018754
更新日期:2005-12-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2011-100556
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To describe the small area system developed in Finland. To illustrate the use of the system with analyses of incidence of lung cancer around an asbestos mine. To compare the performance of different spatial statistical models when applied to sparse data. METHODS:In the small area system, cancer and populati...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.5.315
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:To assess whether CFS-like caseness (meeting the criteria for chronic fatigue syndrome (CFS)) predicts work status in the long term. METHODS:Prospective study in a sample of fatigued employees absent from work. Data were collected at baseline and four years later, and included CFS-like caseness and work stat...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.023176
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:To investigate the relation between pulmonary function and occupational exposure in aluminium pot operators. METHODS:2795 observations were obtained in 630 workers over six years of follow up. An autoregressive method of analysis was used. RESULTS:After adjustment for FEV1 in the three previous years, the ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.1.27
更新日期:1997-01-01 00:00:00
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journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101365
更新日期:2013-08-01 00:00:00
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journal_title:Occupational and environmental medicine
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doi:10.1136/oem.2004.019513
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abstract:OBJECTIVES:To assess if improvement of working conditions related to heat stress was associated with improved kidney health outcomes among sugarcane harvest workers in Chichigalpa, Nicaragua, a region heavily affected by the epidemic of chronic kidney disease of non-traditional origin. METHODS:Based on our findings du...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106406
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:To evaluate whether hourly changes in fine particle (PM(2.5), diameter<2.5 microm) exposure or outdoor particle concentrations are associated with rapid ischaemic responses. METHODS:41 non-smoking elderly people with coronary heart disease were followed up with biweekly clinic visits in Helsinki, Finland. T...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2007.037531
更新日期:2008-11-01 00:00:00
abstract:AIMS:To investigate the acute systemic inflammatory response to welding fume exposure. METHODS:Twenty four welders (42% smokers) and 13 non-exposed controls (23% smokers) were monitored at a welding school. Exposure to fine particulate matter (PM2.5) was assessed using cyclone samplers. Markers of systemic inflammatio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014795
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Combustion-generated fine particulate matter (PM2.5) is associated with cardiovascular morbidity. Both traffic-related air pollution and residential wood combustion may be important, but few studies have compared their impacts. OBJECTIVES:To assess and compare effects of traffic-related and woodsmoke PM2.5 ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/oemed-2014-102696
更新日期:2015-06-01 00:00:00
abstract:AIMS:To investigate the use of a worker based methodology to assess the physical stresses of lifting tasks on effort expended, and to associate this loading with musculoskeletal outcomes (MO). METHODS:A cross sectional study was conducted on 217 male manual handling workers from the Hong Kong area. The effects of four...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.10.730
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVES:Long working hours may be associated with cardiovascular disease (CVD). The objective was to investigate cross-sectional associations of work hours with carotid intima-media thickness (CIMT) and ankle-brachial index (ABI). METHODS:Participants were 1694 women and 1868 men from the Multi-Ethnic Study of Athe...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-100665
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:Previous research has produced conflicting evidence on the relative merits of advancing and delaying shift systems. The current study assessed the effects of the direction of shift rotation within 8 hour systems, upon a range of measures including sleep, on shift alertness, physical health, and psychological...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.10.678
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:Both ambient ozone and temperature are associated with human health. However, few data are available on whether ozone modifies temperature effects. This study aims to explore whether ozone modified associations between maximum temperature and cardiovascular mortality in the USA. METHODS:The authors obtained...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2007.033878
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:Introduced in the UK in 2010, the fit note was designed to address the problem of long-term sickness absence. We explored (1) associations between demographic variables and fit note receipt, 'maybe fit' use and long-term conditions, (2) whether individuals with long-term conditions receive more fit notes and...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2019-106035
更新日期:2020-06-01 00:00:00