Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients.

Abstract:

OBJECTIVE:Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking. PATIENTS AND METHODS:Genotyping for the -25385C/T polymorphism of the PXR gene in 187 white children with IBD and 185 controls. Determination of colonic PXR expression in selected patients with IBD. RESULTS:Minor allele frequency was seen in 35.6% patients with IBD and 40.5% controls (P = 0.174), although no significant differences were seen between the genotypes (P = 0.366). PXR was underexpressed in colonic tissue of 7 out of 11 Crohn disease and in 4 out of 5 patients with ulcerative colitis. CONCLUSIONS:We could not confirm an association of the -25385C/T polymorphism in pediatric patients with IBD.

authors

Lacher M,Kappler R,Schroepf S,Berkholz S,Ballauff A,Bufler P,Baurecht H,von Schweinitz D,Koletzko S

doi

10.1097/MPG.0b013e31818de1a8

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

147-50

issue

1

eissn

0277-2116

issn

1536-4801

journal_volume

49

pub_type

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