Abstract：
:Persistent pulmonary hypertension of the newborn (PPHN) complicated with transposition of the great arteries (TGA) and an intact ventricular septum (IVS) often is therapy resistant and associated with an extremely poor prognosis. For this condition, opening of the ductus arteriosus (DA) by prostaglandin-E1 in conjunction with balloon atrial septostomy and nitric oxide inhalation therapy has been applied as an initial treatment strategy. A case of PPHN with TGA/IVS is presented together with a strategy of intentionally restricted DA to increase pulmonary blood flow successfully used in treating PPHN that otherwise was resistant to conventional therapy. The DA restriction strategy may help to improve the prognosis of patients who have PPHN complicated with TGA/IVS.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Masutani S,Seki M,Taketazu M,Senzaki Hdoi
10.1007/s00246-009-9475-5subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1003-5issue
7eissn
0172-0643issn
1432-1971journal_volume
30pub_type
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