Multidrug-resistant Escherichia coli bacteremia in cancer patients.

Abstract:

BACKGROUND:Multidrug-resistant (MDR) Escherichia coli is a serious threat to cancer patients. We aimed to determine the risk factors associated with the development of MDR E coli bacteremia in cancer patients and the possibility of horizontal transmission. METHODS:We conducted a 1:2 case-control study of 58 patients with MDR E coli bacteremia. The patient's demographics, clinical characteristics, and antibiotic use were obtained. MDR E coli was defined as resistant strains to quinolones plus 1 of the following: piperacillin, ceftazidime, or cefepime. Repetitive sequence-based polymerase chain reaction (Rep-PCR) was used to identify DNA interstrain similarities. RESULTS:Conditional multiple logistic analysis showed that admission to the hospital within the 30 days prior to infection and chemotherapy use were risk factors for infection with MDR E coli. Rep-PCR showed that, among the MDR E coli strains recovered, 48.6% showed >95% similarity, representing a possible clonal outbreak. Infection control measures were implemented and controlled this horizontal transmission. CONCLUSION:Prior admission to the hospital and previous chemotherapy were independent risk factors of acquiring MDR E coli. Molecular fingerprinting techniques detected a possible nosocomial clonal outbreak of MDR E coli, which was aborted through infection control measures.

journal_name

Am J Infect Control

authors

Vigil KJ,Adachi JA,Aboufaycal H,Hachem RY,Reitzel RA,Jiang Y,Tarrand JJ,Chemaly RF,Bodey GP,Rolston KV,Raad I

doi

10.1016/j.ajic.2009.02.002

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

741-5

issue

9

eissn

0196-6553

issn

1527-3296

pii

S0196-6553(09)00429-5

journal_volume

37

pub_type

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