Abstract:
AIMS:We explored the association between exposure to environmental tobacco smoke (ETS) and various cardiometabolic biomarkers in 10-year-old children. METHODS AND RESULTS:A population-based cross-sectional study was carried out. Data on ETS exposure and potential confounders were collected by parental questionnaire. Adiponectin, leptin, markers of inflammation, apolipoproteins (apo) AI and B, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) were measured. Linear and logistic regression models were applied using the 90th percentile as a cut-off point except for adiponectin and apoAI (10th percentile). In linear models, ETS exposure was significantly associated with increasing plasma concentrations of leptin, C-reactive protein, fibrinogen, interleukin (IL)-6, and Lp-PLA(2). When compared with none, ETS exposure of more than 10 cigarettes per day was associated with elevated concentrations of leptin (OR 6.40; 95% CI, 2.67-15.39), C-reactive protein (OR 3.17; 95% CI, 1.31-7.68), Lp-PLA(2) (OR 2.97 95% CI, 1.32-6.68), low adiponectin (OR 2.69; 95% CI, 1.10-6.57), and low apoAI (OR 4.48; 95% CI, 2.16-10.85). Increasing dose of ETS exposure was related to an increasing number of abnormal cardiometabolic markers. CONCLUSION:Among children, ETS exposure was associated with a low-grade inflammatory response and altered markers of lipid metabolism, which may initiate atherosclerosis in early life. However, longitudinal studies are necessary to determine the potential causal relevance of these associations.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Nagel G,Arnold FJ,Wilhelm M,Link B,Zoellner I,Koenig Wdoi
10.1093/eurheartj/ehp180subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1885-93issue
15eissn
0195-668Xissn
1522-9645pii
ehp180journal_volume
30pub_type
杂志文章abstract:AIMS:Prophylactic administration of N-acetylcysteine (NAC) (600mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN. METHODS AND RESU...
journal_title:European heart journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-02-01 00:00:00
abstract::Randomized clinical trials (RCTs) are the definitive contributors to evidence-based medicine. RCTs assessing serious outcomes in cardiovascular disease have grown, with 'megatrials' becoming more common with the realization that wrong conclusions resulted from random error in inadequately sized trials. Simple design a...
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更新日期:1987-08-01 00:00:00
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journal_title:European heart journal
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journal_title:European heart journal
pub_type: 杂志文章
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a060608
更新日期:1994-07-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062100
更新日期:1986-06-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/oxfordjournals.eurheartj.a060486
更新日期:1994-02-01 00:00:00
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更新日期:2003-09-01 00:00:00
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更新日期:2016-02-07 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-05-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
doi:10.1093/eurheartj/ehw564
更新日期:2017-05-01 00:00:00
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journal_title:European heart journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1053/euhj.1999.2005
更新日期:2000-09-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-05-14 00:00:00
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更新日期:2002-05-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,多中心研究
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更新日期:2015-12-21 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062501
更新日期:1988-03-01 00:00:00
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更新日期:2016-06-21 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059849
更新日期:1991-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章,meta分析,评审
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更新日期:2009-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/12.suppl_d.108
更新日期:1991-08-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.7.941
更新日期:1993-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:1993-05-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-08-01 00:00:00