Duodenal ulcer therapy with low-dose antacids: a multicenter trial.

Abstract:

:One hundred outpatients with endoscopically verified duodenal ulcer were treated in a double-blind, randomized, multicenter trial with either low-dose antacid (AA, Supralox, 1 tablet three times a day 1 h a.c. and 2 tablets at bedtime, with acid binding capacity of 225 mEq) or misoprostol (MS, Cytotec, 400 micrograms p.o. b.i.d.). Patients were treated up to 4 weeks and underwent endoscopic and clinical evaluation at 2 and 4 weeks. Clinical symptoms were recorded at the beginning and at 2 and 4 weeks. Ninety-eight patients completed the study. After 4 weeks of treatment, the healing rate in the AA group was 79.6% compared with 74.4% in the MS group. The difference in healing rates between these two groups was statistically not significant. The effect on clinical symptoms assessed as percentage improvement during the therapy was similar under both medications. However, the relief of night pain was significantly higher during the first 2 weeks of AA therapy. The side effects of both treatments were minimal, with a higher rate of side effects (especially diarrhea) in the MS group. Thus, a low-dose antacid tablet regimen is safe and effective therapy for duodenal ulcer patients.

journal_name

J Clin Gastroenterol

authors

Nauert C,Caspary WF

doi

10.1097/00004836-199112001-00025

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

S149-54

eissn

0192-0790

issn

1539-2031

journal_volume

13 Suppl 1

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199108000-00014

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

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