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Vaspin and its correlation with insulin sensitivity indices in obese children.

Abstract：

AIM:The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents. MATERIAL AND METHODS:Plasma vaspin and adiponectin level and its relationships with body mass index standard deviation score (BMI-SDS), insulin sensitivity and lipids were analyzed in 33 pubertal obese children (19 girls and 14 boys) and 36 healthy control children (18 girls and 18 boys) aged 11-16 years. Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR) and fasting glucose-to-insulin ratio (FGIR). Plasma vaspin and adiponectin concentrations were determined with radioimmunoassay. RESULTS:Mean vaspin levels were found significantly higher and inversely, adiponectin levels were found significantly lower in obese pubertal group than control subjects. Vaspin levels were positively correlated with BMI-SDS, triglycerides, fasting insulin and HOMA-IR and negatively correlated with adiponectin levels and FGIR. Adiponectin levels were positively correlated with high density lipoprotein-chloesterol, FGIR and negatively correlated with vaspin, BMI-SDS, fasting insulin and HOMA-IR. CONCLUSION:We found higher vaspin and lower adiponectin levels in obese children and these adipokines were significantly correlated with insulin sensitivity indices in this age.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Suleymanoglu S,Tascilar E,Pirgon O,Tapan S,Meral C,Abaci A

doi

10.1016/j.diabres.2009.03.008

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

325-8

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(09)00123-5

journal_volume

84

pub_type

杂志文章

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