A retrospective analysis of thirty-one cases of plasma cell leukemia from a single center in China.

Abstract:

BACKGROUND/AIMS:The study was undertaken to understand the characteristic of plasma cell leukemia (PCL) in China. METHODS:We reviewed and compared medical data of 22 primary PCL, 9 secondary PCL and 461 multiple myeloma (MM) diagnosed at our institute from January 2000 to January 2008. RESULTS:The median onset ages of primary and secondary PCL patients were 49.5 and 56 years, respectively. PCL patients presented with a low peripheral blood plasmacytosis, extensive involvement of visceral organs and poor residual bone marrow function, without severe renal insufficiency. Seventeen of twenty-one PCL patients had abnormal karyotypes, mostly complex and hypodiploid or pseudodiploid. The deletion of 13q was frequent in primary and secondary PCL (57.1 and 42.9%, respectively). There was a significant difference in survival among primary PCL, secondary PCL and MM (median 14, 2 and 37 months, respectively, p = 0.0000). CONCLUSION:Overall, primary and secondary PCL are different disorders with distinct natural histories and survival.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Peijing Q,Yan X,Yafei W,Dehui Z,Zengjun L,Junyuan Q,Yaozhong Z,Lugui Q

doi

10.1159/000210555

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

47-51

issue

1

eissn

0001-5792

issn

1421-9662

pii

000210555

journal_volume

121

pub_type

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