Abstract:
:Clinical trials in paediatric cancer continue to be a key factor in progress toward better treatment and prognosis. Paediatricians and family physicians may be asked by patients and families for their advice regarding participation in such trials. The significant advances in the success of treatment of paediatric cancer have come, in part, from the high participation rate of patients in such studies. The present article reviews the definitions and goals of phase 1, 2 and 3 trials. A known and trusted physician or paediatrician can be helpful in conjunction with the oncologist in guiding patients and their families and helping them understand the risks and benefits of participation in clinical trials.
journal_name
Paediatr Child Healthjournal_title
Paediatrics & child healthauthors
Bond MC,Pritchard Ssubject
Has Abstractpub_date
2006-03-01 00:00:00pages
148-50issue
3eissn
1205-7088issn
1918-1485journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Despite the important role of drug therapy in children, there is often a lack of readily available information regarding the indications and dosing regimens for medications in paediatrics. OBJECTIVE:To collect data on where family physicians obtain this prescribing information. METHOD:A structured question...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/8.4.219
更新日期:2003-04-01 00:00:00
abstract::Over the past decade, the unfortunate reality is that the income gap has widened between Canadian families. Educational outcomes are one of the key areas influenced by family incomes. Children from low-income families often start school already behind their peers who come from more affluent families, as shown in measu...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/12.8.701
更新日期:2007-10-01 00:00:00
abstract::Zika virus (ZIKV) was recently recognized to be teratogenic. The diagnosis of congenital ZIKV syndrome should be considered in children with unexplained microcephaly, intracranial calcifications, ventriculomegaly or major structural central nervous system abnormalities. Management is evolving but suggestions are provi...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/pxx012
更新日期:2017-03-01 00:00:00
abstract::[This corrects the article on p. 12 in vol. 20, PMID: 25722635.]. ...
journal_title:Paediatrics & child health
pub_type: 已发布勘误
doi:
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:In September 2005, the Alberta government introduced the daily physical activity (DPA) initiative, which requires that students from grades 1 to 9 be physically active in school for a minimum of 30 min per day. OBJECTIVE:To obtain information on whether and how the DPA initiative has been implemented in C...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/15.7.e19
更新日期:2010-09-01 00:00:00
abstract::Respite care is one integral component of the transition process from paediatric to adult health care, and is of particular importance to individuals with medical complexities. Numerous gaps that exist within the current system limit a child and family's ability to access quality respite care during a time when it is ...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/pxx142
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:A checklist that promotes compliance with aseptic technique during line insertion is a component of many care bundles aimed at reducing nosocomial infections among intensive care unit patients. OBJECTIVE:To determine whether the use of bundled interventions that include a checklist during central-line inser...
journal_title:Paediatrics & child health
pub_type: 杂志文章,评审
doi:10.1093/pch/19.4.e20
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:A checklist that promotes compliance with aseptic technique during line insertion is a component of many care bundles aimed at reducing nosocomial infections among intensive care unit patients. OBJECTIVE:To determine whether the use of bundled interventions that include a checklist during central-line inser...
journal_title:Paediatrics & child health
pub_type: 杂志文章,评审
doi:10.1093/pch/19.4.176
更新日期:2014-04-01 00:00:00
abstract::Antimicrobial stewardship is a recent concept that embodies the practical, judicious use of antimicrobials to decrease adverse outcomes from antimicrobials while optimizing the treatment of bacterial infections to reduce the emergence of resistant pathogens. The objectives of the present statement are to illustrate th...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/19.5.261
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To determine whether a simple, nonsurgical treatment for congenital ear abnormalities (lop-ear, Stahl's ear, protruding ear, cryptotia) improved the appearance of ear abnormalities in newborns at six weeks of age. METHODS:This is a descriptive case series. All newborns with identified abnormalities were refe...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/10.6.327
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:To explore how and when chiropractors are involved in the care of patients younger than 18 years of age, and to examine chiropractors' beliefs about treating paediatric patients. DESIGN:A cross-sectional survey of a random sample of 140 chiropractors practising in Alberta. Data were collected by means of a ...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/6.7.433
更新日期:2001-09-01 00:00:00
abstract::This statement is intended for health care professionals caring for neonates and young infants. The objectives of this statement are to review the short and long term effects of systemic and inhaled postnatal corticosteroids for the prevention or treatment of evolving or established chronic lung disease, and to make r...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/7.1.20
更新日期:2002-01-01 00:00:00
abstract::Child sexual abuse is an important and not uncommon problem. Children who have been sexually abused may present to a physician's office, urgent care centre, or emergency department for medical evaluation. A medical evaluation can provide reassurance to both child and caregiver, identify care needs, and offer an accura...
journal_title:Paediatrics & child health
pub_type: 杂志文章,评审
doi:10.1093/pch/pxaa019
更新日期:2020-04-01 00:00:00
abstract::The management of patients with headaches is a major component of every paediatric practice. In a nationally representative sample of Canadian adolescents, it was found that 26.6% of those 12 to 13 years of age and 31.2% of those 14 to 15 years of age reported that they experienced headaches at least once per week.The...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/14.1.24
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To describe the clinical features, diagnosis, treatment and outcome of children with Kawasaki disease (KD) treated at a large tertiary care Canadian paediatric hospital and to try to identify correlations between clinical features and the development of coronary artery abnormalities. METHODS:The charts of 1...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/9.7.466
更新日期:2004-09-01 00:00:00
abstract::Sexual activity and experimentation are normative parts of adolescent development that may, at the same time, be associated with adverse health outcomes, including the acquisition of sexually transmitted infections, unplanned pregnancy, and teen dating violence. Anticipatory guidance regarding sexual and reproductive ...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/pxaa122
更新日期:2020-12-16 00:00:00
abstract:BACKGROUND:Child abuse and neglect (CAN) represents an international public health and societal problem, the extent and nature of which are inadequately understood. Child and youth protection programs (CYPPs), based in 16 Canadian paediatric academic health science centres, identify, manage, treat and prevent cases of ...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::Acute otitis media (AOM) continues to be a common infection in young children. Milder disease, usually due to viruses or less virulent bacteria, resolves equally quickly with or without antibiotics. A bulging tympanic membrane, especially if yellow or hemorrhagic, has a high sensitivity for AOM that is likely to be ba...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/21.1.39
更新日期:2016-01-01 00:00:00
abstract::Sepsis is a systemic inflammatory response to suspected or proven infection. Given its importance in terms of morbidity and mortality, a number of initiatives by several professional societies in recent years have led to the development of guidelines for the recognition and timely management of sepsis. The principal e...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/pxz178
更新日期:2020-11-02 00:00:00
abstract:INTRODUCTION:A number of reports suggest that Aboriginal cultural status is a major risk indicator for drug and alcohol use. The primary purpose of the present paper was to determine whether Aboriginal cultural status is independently associated with risk behaviours, such as marijuana use and alcohol abuse, among youth...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/14.4.225
更新日期:2009-04-01 00:00:00
abstract::In the present longitudinal study, the physical growth and health of 36 early-deprived postinstitutionalized Romanian orphans (ROs; 17 boys) adopted by Canadian families are documented. Data were collected for each child at three time points: at 11 months postadoption, at 4.5 years of age and at 10.5 years of age. Dat...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To review the risks of injury to children in the hospital setting and to provide an overview of the factors which influence the approach to hospital safety, including institutional liability, hospital accreditation, patient safety and risk management issues. METHODS:Fatal and nonfatal injuries to children i...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::Hydrogenation of fat products is used in the food industry to extend their shelf life. Trans fats are the result of partial hydrogenation of unsaturated fat. Trans fats increase low-density lipoprotein cholesterol and decrease high-density lipoprotein cholesterol, thus increasing the risk of cardiovascular disease. Ca...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/15.6.373
更新日期:2010-07-01 00:00:00
abstract::Nutrition is an important part of sport performance for young athletes, in addition to allowing for optimal growth and development. Macronutrients, micronutrients and fluids in the proper amounts are essential to provide energy for growth and activity. To optimize performance, young athletes need to learn what, when a...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/18.4.200
更新日期:2013-04-01 00:00:00
abstract:Objective:To examine changes in the awareness, use, feasibility, and barriers associated with the Canadian Physical Activity and Sedentary Behaviour Guidelines for Children and Youth ages 0-17 years in a sample of Canadian paediatricians, and to assess tools/resources developed by the Canadian Paediatric Society (CPS)....
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/pxx006
更新日期:2017-03-01 00:00:00
abstract::Canadian subspecialty residency training programs are developed around the learning objectives listed in the seven Canadian Medical Education Directives for Specialists (CanMEDS) criteria. Delivering content on objectives outside of those traditionally acquired in clinical rotations can be a challenge. In the present ...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/17.10.544
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The treatment of celiac disease is a strict, life-long gluten-free (GF) diet. This diet is complex and can be challenging. Factors affecting adherence to the GF diet are important to identify for improving adherence. OBJECTIVE:To identify factors that inhibit or improve adherence to a GF diet in children wi...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/19.6.305
更新日期:2014-06-01 00:00:00
abstract::Although acute and subacute lead toxicity requiring active treatment is rare in Canada, paediatricians need to be aware of new evidence linking lower lead levels to neurodevelopmental deficits. Health Canada has identified potential exposures occurring prenatally, in infancy and during early childhood from food and wa...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/pxz080
更新日期:2019-07-01 00:00:00
abstract:Background:Referrals to paediatric endocrine clinics for short stature are common. Height velocity (HV) is an essential component of the evaluation of short stature as growth deceleration often reflects an underlying paediatric endocrine diagnosis (PED). Access to previous measurements facilitates prompt calculation of...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/pxy079
更新日期:2019-05-01 00:00:00
abstract::Persistent fetal circulation (PFC), also known as persistent pulmonary hypertension of the newborn, is defined as postnatal persistence of right-to-left ductal or atrial shunting, or both in the presence of elevated right ventricular pressure. It is a relatively rare condition that is usually seen in newborns with res...
journal_title:Paediatrics & child health
pub_type: 杂志文章
doi:10.1093/pch/6.10.744
更新日期:2001-12-01 00:00:00