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Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.

Abstract：

:To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS). DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negative exponential correlation related DA level and disease duration. The HVA/DA ratio was significantly higher in the ADV and DYS group than that found in DEN group. Our data show that disease progression produces an early large decay of DA levels, followed by a stabilization. On the contrary, a late change in DA turnover (increased HVA/DA ratio) is documented in patients with longer disease duration. Our results suggest that the appearance of dyskinesia may not be related to a further loss of DA terminals but to a different, abnormal, DA turnover.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Lunardi G,Galati S,Tropepi D,Moschella V,Brusa L,Pierantozzi M,Stefani A,Rossi S,Fornai F,Fedele E,Stanzione P,Hainsworth AH,Pisani A

doi

10.1016/j.parkreldis.2008.10.001

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

383-9

issue

5

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(08)00278-2

journal_volume

15

pub_type

杂志文章

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