Abstract:
:Forty-five antiretroviral-naive HIV-1 infected patients and 14 healthy controls in North China were enrolled in this study. The frequency of CD4+CD25+Foxp3+ regulatory T cells (Tregs) and levels of expression of CD95, HLA-DR and CD38 in T cells were detected by flow cytometry. We found that the frequency of Tregs was higher in AIDS patients than in asymptomatic HIV-1 infected patients (P=0.004). The frequency of Tregs was significantly correlated with absolute CD4 count, viral load, CD4+CD95+ T cells and CD8+CD95+ T cells (P<0.05). The relationship between the frequency of Tregs and immune activation was not found in HIV-infected patients. We concluded that the frequency of Tregs in HIV-infected Chinese patients was significantly correlated with disease progression.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Zhang Z,Jiang Y,Zhang M,Shi W,Liu J,Han X,Wang Y,Jin X,Shang Hsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
391-2issue
5eissn
1344-6304issn
1884-2836journal_volume
61pub_type
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