Abstract：
:Infection of secondary mouse fibroblast cultures with human cytomegalovirus (HCMV) led to the production of viral antigens in the absence of detectable virus replication. Antigen production was not dependent on viral DNA synthesis since it was not inhibited by cytosine arabinoside. Beginning at 15 days post-infection, viral-specific antigens were no longer observable in infected cultures, but could be induced by iododeoxyuridine (IUDR) treatment. Such cultures carry HCMV genetic information in a latent, unexpressed, state. Fusion of latently-infected mouse cells with human fibroblasts also induced viral-specific antigens, but no detectable virus replication, in the resulting heterokaryons. However, upon IUDR treatment of heterokaryons, or of the mouse cells prior to fusion, antigens characteristic of the late stages of virus replication appeared, and infectious CMV could be detected. Thus, it appears that the non-permissive (mouse) cell genome is dominant, and continues to regulate viral gene expression in heterokaryons formed with permissive (human) cells.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Boldogh I,Gönczöl E,Gärtner L,Vaczi L,Michelson Ssubject
Has Abstractpub_date
1976-07-01 00:00:00pages
411-6issue
3eissn
0007-4551issn
1769-6917journal_volume
63pub_type
杂志文章abstract：:Psychoanalysts working in cancerology have to face three main difficulties concerning their methodology: the selection of representative populations, the identification of prospective factors and the choice and definition of the data they need to collect. Four examples are given hereafter: a prospective study on the p...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Testicle germ cells tumors are the most common young men neoplasm. The incidence is maximal in Scandinavian countries. Cryptorchidism is a predisposing factor. Diagnosis is clinic, first treatment is radical orchidectomy by inguinal incision, after study of tumor markers. Histology shows seminoma or non seminomatous t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:In 2002, new developments in anti-angiogenic strategies encompassed two main aspects. Firstly, essential improvements were made in the field of methodology : novel techniques permitted to measure directly on patients the biological effects induced by anti-angiogenic treatments in the course of clinical trials. Secondl...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Seventy-five patients with locally advanced non small cell lung carcinoma were entered in a phase II study combining chemotherapy (vindesine, lomustine, cisplatin and cyclophosphamide) and radical thoracic radiotherapy delivering a total dose of 60-65 Gy. Patients were regularly assessed by radiological and fiberoptic...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The considerable progress of molecular biology within the past twenty years has permitted a more and more detailed characterization of the molecular mechanisms regulating cell proliferation. The corollary to these discoveries has been the identification of different deregulations yielding to cell transformation and ca...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-04-01 00:00:00
abstract：:Hepatocellular carcinoma is the third most frequent cause of cancer death worldwide, particularly in Asia and Africa. Most cases complicate an underlying liver cirrhosis due to hepatitis B or C chronic virus infection or alcoholic abuse. But, following the current epidemics of obesity and type 2 diabetes, it appears t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.02.003
更新日期：2018-05-01 00:00:00
abstract：:From 1941, estrogens are usually used in the treatment of prostatic carcinoma, wrongly in case of adjuvant hormonotherapy and exceedingly because of cardiovascular toxicity from over dosages. A recall of their mechanism of action and toxicity allows to argue about the palliative treatment and to look to their use for ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Management of rectal cancers with synchronous metastasis is difficult. We evaluated in 23 patients a combination of pelvic radiotherapy at the dose of 45 Gy in 5 weeks and 25 fractions with chemotherapy by 5-fluorouracil (350 mg/m2/day) and folinic acid (20 mg/m2/day) for 5 days at the time of the first and the fifth ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:Distinct clinicopathologic acute lymphoblastic leukemia (ALL) entities have been identified, resulting in the adoption of risk-oriented treatment approaches. In Philadelphia chromosome-positive (Ph(+)) ALL, the optimal treatment requires the addition of BCR-ABL tyrosine kinase inhibitors, as imatinib. However, the out...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1390
更新日期：2011-07-01 00:00:00
abstract：:Androgen deprivation in patients with metastatic prostate cancer produces palliation of symptoms, PSA decrease and tumoral regression in most patients. After a brief period of disease regression lasting 18 to 24 months nearly all pts will progress to androgen independence disease (HRPC) with progressive clinical deter...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-07-01 00:00:00
abstract：:Phase III clinical trials (CT) are carried out more and more often in a multicentric way, under the aegis of one or more cooperative groups (CG). The goal of this study was to analyze the influence of the GC on ethical quality (EQ) and methodological quality (MQ) in phase III cancer CT. EQ (Berdeu-score) and MQ (Jadad...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-10-01 00:00:00
abstract：:A suspension of CE "44" embryoïd-bodies obtained from a transplanted OTT 60-50 subline was injected into the abdominal cavity of syngeneic L 129 mice. Terato-carcinoma and ascitic fluid were produced the latter containing embryoïds. In situ examinations were made by serial transverse sectioning of the entire abdomen. ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
abstract：:296 intraoral minor salivary gland tumors were observed among 702 salivary tumors. The study emphasizes a frequent palatine location, observed in more than 50 per cent of theses tumors. Pleiomorphic adenomas (or so called mixed tumors), are frequently encountered; but it is noteworthy that the proportion of muco-epide...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The evaluation of the risk-benefit balance in public health is an ethical commitment, based on the imperative of not harming people. Screening is a probabilistic approach, which, in order to serve the needs of a few, involves the largest number to share the potential harmful effects. Improvement of scientific knowledg...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2018.04.008
更新日期：2019-01-01 00:00:00
abstract：:DNA methylation is known to be related to the regulation of gene expression. DNA methylation patterns are modified in tumors compared to normal tissue, and in some cases, these variations are linked to cancer progression. Molecular biology techniques are generally used to evaluate DNA methylation status. We describe h...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:The dismal outcome of ovarian, fallopian tube, and primary peritoneal carcinomas calls for an increase in surgical aggressiveness. After a long era during which incomplete cytoreduction was considered acceptable, it has been established that the outcome is directly related to the amount of diseased tissue left in plac...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2009.0989
更新日期：2009-12-01 00:00:00
abstract：:Endometrial cancer is a common cancer in older women and is often associated with comorbidities. Management of metastatic disease and/or relapse requires a multidisciplinary approach. Recent advances in the understanding of oncogenesis and molecular classification of endometrial cancers offer new therapeutic perspecti...
journal_title：Bulletin du cancer
pub_type： 杂志文章,实务指引
doi：10.1016/j.bulcan.2020.06.006
更新日期：2020-10-01 00:00:00
abstract：:The increasing complexity of present day medicine--with highly effective and yet risky treatments, individual and collective expectations, and evolving ideological and cultural landmarks--often gives rise to difficult ethical problems. Specific meetings are valuable for understanding such problems, acquiring the relev...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Breast cancer of young women has medico-psychological issues, particularly in the perspective of "after cancer" period. The objective of the study was to analyze the changes in management, in a decade including the publication of Cancer Plans I and II. METHODS:This retrospective unicentric study involved ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/S0007-4551(20)30049-7
更新日期：2019-12-01 00:00:00
abstract：:Two criteria are firstly used in the selection of new anticancer agents:--originality of the mechanism of action and significant experimental antitumor activity in an in vivo animal model. Murine tumors grafted in syngenic mice and human tumor xenografts implanted in nude mice are old models which continue to be widel...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:The group of rare malignant ovarian tumors includes the group of germ cell tumors, sex cords stromal ovarian tumors, small cell carcinoma, malignant Brenner tumors, rare epithelial tumors such as mucinous carcinoma, clear cell carcinoma, or low-grade serous carcinoma, as well as ovarian carcinosarcoma. Together they c...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2020.01.011
更新日期：2020-03-01 00:00:00
abstract：:Two hundred different mendelian genes can have a cancerogenic effect in man, but it is difficult to make out between the genetic and the environmental part. Acute lymphoblastic leukemia is an example that the actual cancerogenic factor can be environmental and not genetic. Genetically controlled tumors can result from...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1978-01-01 00:00:00
abstract：:The dependency between the risk of death and age is analysed, and the contribution of cancer to the overall risk of death is evaluated as a function of age. The frequency of the different cancer sites is described in different age groups. Lastly cancer mortality trends are presented by age. The risk of death from canc...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2007.0531
更新日期：2008-05-28 00:00:00
abstract：:The network of cancer care units in Lorraine area (Oncolor) developed management training for people working in chemotherapy units, and cytotoxic drug preparation. The programme was framed both for staff of executives (pharmacists), and technicians. Firstly, comparison between practices and theoretical recommendations...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:Advances in early detection and treatment have pushed in a few decades the management of cancers from a management model of the end of life to the management of a chronic disease. This evolution has accelerated the development of supportive care in two directions, firstly towards the best possible support to the end o...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.04.007
更新日期：2018-09-01 00:00:00
abstract：:This study was performed in a group of 89 patients treated for breast carcinoma with a FEC regimen (5-fluorouracil, epirubicin, cyclophosphamide). The aim was to evaluate the antiemetic efficacy of one 8 mg tablet ondansetron (OND), and in case of failure, to measure the recovering level by the administration of 8 mg ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The physician-patient relationship has three main stakes : creating a high-quality inter-personal relationship, exchanging information and decision-making. The achievement of these stakes implies that the physician and the patient are able to reach specific communicational objectives. The aim of this paper is to revie...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-01 00:00:00
abstract：:Statistical, biological and chemical data on the carcinogenic effect of tobacco smoke are given and are discussed. The epidemiological studies have clearly shown the particularly noxious action of inhalation, and the direct ratio between the risk and the number of cigarettes smoked. The laboratory experiments on biolo...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Sixty percent of cancer patients have or develop bone metastases during the development of their cancer. Bone metastases are the most common cause of cancer-related pain. External radiation therapy is the standard treatment of uncomplicated bone metastases, for the treatment of pain, the prevention of fracture, and fo...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2013.1845
更新日期：2013-11-01 00:00:00
abstract：:Localization of the sentinel lymph node (SLN) in digestive cancers was performed mainly for colorectal primaries and less frequently for oeso-gastric primaries. This technique is feasible in vivo or ex vivo, with a vital dye and/or with a radiolabeled marker. Technically, detection reliability is good, provided a few ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-06-01 00:00:00
