[Combination of chemotherapy (vindesine, lomustine, cisplatin, cyclophosphamide) and thoracic radiotherapy in nonresectable non-small cell bronchial carcinoma: final results of a phase II clinical trial].

Abstract:

:Seventy-five patients with locally advanced non small cell lung carcinoma were entered in a phase II study combining chemotherapy (vindesine, lomustine, cisplatin and cyclophosphamide) and radical thoracic radiotherapy delivering a total dose of 60-65 Gy. Patients were regularly assessed by radiological and fiberoptic bronchoscopy examinations in order to evaluate local control. An objective response was observed in 22 patients (29%) after initial chemotherapy (2 complete remissions and 20 partial responses). The complete response rate after the combined schedule was 30%. Toxicity of this combination was acceptable. Median survival was 13.5 months. Actuarial risk of developing distant metastases at 3 years was 60%. However, the main cause of failure was local with 80% of uncontrolled or recurrent thoracic tumor in the first 2 years of follow-up. The present study shows that local control remains a major problem in the management of patients with inoperable non metastatic non small cell lung cancer.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Nasr E,Pellae-Cosset B,Arriagada R,Le Chevalier T,Baldeyrou P,Ruffie P,de Cremoux H,Martin M,Tarayre M

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

681-7

issue

7

eissn

0007-4551

issn

1769-6917

journal_volume

79

pub_type

临床试验,杂志文章
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    doi:

    authors: Levy R,Andrieu JM,Even P

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    doi:

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  • [Obstacles and reticences in the screening of cancer of the cervix by the general practitioner].

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    doi:

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    更新日期:1994-04-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    doi:

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  • [Opioid switch and change of route of administration in cancer patients treated by morphine].

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  • [Treatment of mucositis pain: News and prospects].

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  • [History and new development of screening and evaluation methods of anticancer drugs used in vivo and in vitro].

    abstract::Screening methods for the detection of anticancer activity are of crucial importance in order to find solid tumor-specific agents. A review of past screening methods is followed by a description of present methodologies targetted toward the discovery of such agents. Finally, we discuss primary and secondary in vivo ev...

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    pub_type: 历史文章,杂志文章,评审

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  • [Nomograms in routine clinical practice: Methodology, interest and limitations].

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  • [Integrins, cell response to anti-tumor agents and chemoresistance].

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  • [Molecular biology of sarcoma and therapeutic choices].

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  • [Evaluation of professional practices: improving cancer related-pain management in radiation oncology].

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    doi:

    authors: Lidereau R,Chermann JC,Gruest J,Montagnier L,Ducrocq C,Rivalle C,Bisagni E

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Lumbroso J,Guermazi F,Hartmann O,Coornaert S,Rabarison Y,Lemerle J,Parmentier C

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  • [Sentinel node biopsy in breast cancer].

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  • [The frequency of cancer in France in year 2002, and trends since 1968].

    abstract::The estimated number of cancers diagnosed in 2002 is 150,000 in the male population and 120,000 in the female population and there were close to 88,000 cancer deaths among men and 59,000 cancer deaths among women in France. The most frequent cancer sites in the male population are prostate, lung, colon, intestine and ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

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    更新日期:2006-01-01 00:00:00

  • [The cost of radiotherapy].

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

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  • Latent infection of mouse cells with human cytomegalovirus.

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    pub_type: 杂志文章

    doi:

    authors: Boldogh I,Gönczöl E,Gärtner L,Vaczi L,Michelson S

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  • [Place of autologous and allogeneic hematopoietic stem cell transplantation in ovarian cancer].

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