[Combination of chemotherapy (vindesine, lomustine, cisplatin, cyclophosphamide) and thoracic radiotherapy in nonresectable non-small cell bronchial carcinoma: final results of a phase II clinical trial].

Abstract:

:Seventy-five patients with locally advanced non small cell lung carcinoma were entered in a phase II study combining chemotherapy (vindesine, lomustine, cisplatin and cyclophosphamide) and radical thoracic radiotherapy delivering a total dose of 60-65 Gy. Patients were regularly assessed by radiological and fiberoptic bronchoscopy examinations in order to evaluate local control. An objective response was observed in 22 patients (29%) after initial chemotherapy (2 complete remissions and 20 partial responses). The complete response rate after the combined schedule was 30%. Toxicity of this combination was acceptable. Median survival was 13.5 months. Actuarial risk of developing distant metastases at 3 years was 60%. However, the main cause of failure was local with 80% of uncontrolled or recurrent thoracic tumor in the first 2 years of follow-up. The present study shows that local control remains a major problem in the management of patients with inoperable non metastatic non small cell lung cancer.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Nasr E,Pellae-Cosset B,Arriagada R,Le Chevalier T,Baldeyrou P,Ruffie P,de Cremoux H,Martin M,Tarayre M

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

681-7

issue

7

eissn

0007-4551

issn

1769-6917

journal_volume

79

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章

    doi:

    authors: Delarue JC,Avril MF,Prade M,Petit JY

    更新日期:1986-01-01 00:00:00

  • [Gangliosides and cancer].

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    pub_type: 杂志文章,评审

    doi:

    authors: Dumontet C,Portoukalian J

    更新日期:1991-01-01 00:00:00

  • [Infiltrating carcinoma of the uterine cervix: epidemiology, prognostic factors, therapeutic strategies].

    abstract::In industrialized countries cervical cancer has decreased over the past decades. This, thanks to wide spread screening campaigns of precancerous lesions and microinvasive diseases through regular pap smears starting from the beginning of sexual activity. The diagnostic is realized earlier, thus increasing the rate of ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Pereira R,Renard A,Boulbair F,Touboul E,Lefranc JP

    更新日期:1998-11-01 00:00:00

  • [Medico-economical assessment in cancerology].

    abstract::In recent studies, the economic criteria has begun to be integrated to the appraisal in cancerology. The question asked by the economist can be framed as follows: what incremental cost should the collectivity or the health insurance system consent, in order to improve the care of cancer patients? This involves first t...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Lebrun T,Selke B,Bercez C,Bonneterre ME,Lenne X,Sailly JC,Bonneterre J

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  • [Role of adjuvant chemotherapy in the treatment of soft tissue sarcoma].

    abstract::Important improvements in local control with increasing function-sparing treatment have been achieved in adult soft tissue sarcomas (STS). However, the global prognosis of these diseases remains poor and 40% of patients with STS currently die of metastases within 5 years. In fact, the impact of chemotherapy remains de...

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    pub_type: 杂志文章,meta分析

    doi:

    authors: Debled M,Ravaud A,Stöckle E,Nguyen BB

    更新日期:1997-06-01 00:00:00

  • [What future for circulating tumor DNA? Current data and prospects in colorectal, non-small cell lung and pancreatic cancers].

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

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  • [Cervical cancer screening for high risk women: is it possible? Results of a cervical cancer screening program in three suburban districts of Lyon].

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Mignotte H,Perol D,Fontanière B,Nachury LP,Blanc-Jouvand A,Fouillat V,Chauvin F,Lasset C

    更新日期:1999-06-01 00:00:00

  • [Larynx cancer in France: descriptive epidemiology and incidence estimation].

    abstract::The epidemiology of cancers is known in France through mortality data provided by Inserm and morbidity data obtained by French tumor registries. The purpose of this study was to compare the incidence of laryngeal cancers in 9 French departments and to give an estimate of this incidence for the whole of France, based o...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Peng J,Ménégoz F,Lesec'h JM,Remontet L,Grosclaude P,Buémi A,Guizard AV,Tretarre B,Danzon A,Velten M,Maarouf N,Jougla E,Launoy G,Dubreuil A

    更新日期:2004-04-01 00:00:00

  • [Gene therapy of primary cancers of the liver: hopes and realities].

    abstract::Many efforts have been devoted to the development of gene therapy for primary liver tumors. This has been hampered by the absence of efficient gene transfer vectors for delivering genes into hepatoma cells in vivo. Also it remains to determine which type of gene has to be used to achieve complete tumor regression. Rec...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Ferry N

    更新日期:1997-04-01 00:00:00

  • [Importance of a multidisciplinary approach to metastatic cancer of the rectum].

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Mitry E,Pompili PL,Rougier P,Toma C,Ducreux M,Lusinchi A,Elias D,Fabri MC,Bourhis J,Kac J,Eschwege F,Lasser P

    更新日期:1998-08-01 00:00:00

  • [Melanomas of the female genital tract: state of the art].

    abstract::Melanoma of the female genital tract is a rare location (less than 2% of melanomas all sites combined). These cancers have a very poor prognosis, due to the delay in diagnosis. Vulvar location is about 1% of melanomas then the vaginal location, uterine and ovarian. There is no consensus to date regarding their care, d...

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    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2013.1881

    authors: Trone JC,Guy JB,Mery B,Langrand Escure J,Lahmar R,Moncharmont C,Rivoirard R,Semay T,Chauleur C,Collard O,Vignot S,Magné N

    更新日期:2014-01-01 00:00:00

  • [DNA mismatch repair and BRAF status in colorectal cancer: Interest for the therapeutic management?].

    abstract::Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in France. Recently, colorectal cancer subtyping consortium (CRCSC) identified 4 consensus molecular subtypes (CMS). CMS1 is enriched for CRC with deficient DNA mismatch repair system (dMMR) and tumors with mutated BRAF. Intriguingly, CMS1...

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  • [Decision making process in oncology: rationale and delineation of a composite index of relative antitumoral efficacy (In-RATE)].

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    doi:10.1684/bdc.2008.0738

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  • [Cancer of the uterine cervix in young women. A retrospective study of 337 cases].

    abstract::A retrospective study of 337 cases of cervix cancers in women aged 35 years and under, treated between 1980-1990 at the Ibn Rochd Oncology Center in Casablanca, was analyzed in order to determine the main characteristics of this disease and the influence of age on prognosis. The incidence of these cases was stable thr...

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    pub_type: 杂志文章,评审

    doi:

    authors: Acharki A,Sahraoui S,Benider A,Tawfiq N,Jouhadi H,Bouras N,Samlali R,Kahlain A

    更新日期:1997-04-01 00:00:00

  • Unraveling the biology of multiple myeloma disease: cancer stem cells, acquired intracellular changes and interactions with the surrounding micro-environment.

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2008.0600

    authors: Caers J,Van Valckenborgh E,Menu E,Van Camp B,Vanderkerken K

    更新日期:2008-03-01 00:00:00

  • [Oncolor is ten years old: the age of discretion for the Lorraine network in oncology].

    abstract::Oncolor, network in oncology in Lorraine, was born ten years ago, from a group of professionals in the field of oncology who worked closed together with regional administrative authorities. Oncolor was created with respect of equilibrium between the different regional partners avoiding struggle for power. Oncolor was ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Bey P,Bouvier R,David M,Delena G,Garin H,Kessler Y,Klein I,Krakowski I,Lang MP,Leclercq JM,Level MC,Luron R,May I,Nabet M,Ruck S,Sommelet D,Theobald S,Unvois R,Walter S

    更新日期:2004-07-01 00:00:00

  • [Li-Fraumeni syndrome].

    abstract::The Li-Fraumeni syndrome is an autosomal dominant syndrome representing a genetic predisposition to a wide spectrum of tumours including sarcomas, breast carcinomas, brain tumors and adrenocortical carcinomas. In most of the cases, tumours will develop in children and young adults. Germline mutations of the tumor supp...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Frebourg T

    更新日期:1997-07-01 00:00:00

  • [Mechanisms and role of lymphangiogenesis in cancer metastasis].

    abstract::An important critical point in tumor progression is the acquisition of metastatic potential. The presence of metastases in regional lymph nodes is an indicator of poor survival. The vascular endothelial growth factor (VEGF) family of growth factors and receptors is involved in vasculogenesis and angiogenesis. Among th...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Dupuy E,Tobelem G

    更新日期:2003-07-01 00:00:00

  • [Innovation in radiotherapy: A glance at 2018].

    abstract::Innovation in radiotherapy should meet multiple challenges, both technically, biologically, clinically and socially. Scientific, technological and biological advances have resulted in major changes in the implementation, indications, and therapeutic index of radiotherapy over the last century. Based on technical innov...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2018.12.006

    authors: Vial N,Vallard A,Jmour O,Rehailia-Blanchard A,Ben Mrad M,Trone JC,Daguenet E,Guy JB,Magné N

    更新日期:2019-01-01 00:00:00

  • [Not Available].

    abstract:SURGICAL DE-ESCALATION FOR INVASIVE BREAST CANCER TREATMENT:A surgical therapeutic de-escalation is going to continue but necessarily has to design in a progressive careful way and especially arranged with the other practitioners and therapeutic methods. These strategies concern as well the surgery of the breast as tha...

    journal_title:Bulletin du cancer

    pub_type: 社论

    doi:10.1016/S0007-4551(16)30151-5

    authors: Houvenaeghel G,Cohen M,Bannier M,Jauffret C,Buttarelli M,Lambaudie E

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  • [Axillary lymphadenectomy prepared by fat aspiration versus functional axillary lymphadenectomy: preliminary results of a randomized prospective study].

    abstract::The objective of this study is to compare morbidity between 2 surgical procedures of axillary clearance: functional lymphadenectomy by classical dissection versus axillary dissection prepared by liposuction (Suzanne's procedure). Two hundred consecutive patients treated for breast cancer were included in a prospective...

    journal_title:Bulletin du cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Giard S,Laurent JC,Dron AM,Lefebvre D

    更新日期:1997-03-01 00:00:00

  • [Radiotherapy of bone metastases].

    abstract::Sixty percent of cancer patients have or develop bone metastases during the development of their cancer. Bone metastases are the most common cause of cancer-related pain. External radiation therapy is the standard treatment of uncomplicated bone metastases, for the treatment of pain, the prevention of fracture, and fo...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2013.1845

    authors: Leysalle A,Fric D,Lagrange JL,Thariat J

    更新日期:2013-11-01 00:00:00

  • [Irinotecan for the treatment of metastatic colorectal cancer].

    abstract::In a dozen years of development, irinotecan (CPT11) became one of major therapeutics in the taking care of the metastatic colorectal cancer (CCRM). First used in monotherapy every three weeks, irinotecan has been later developed in association with 5FU and folinic acid according to two modalities of administration (bo...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Assenat E,Duffour J,Ychou M

    更新日期:2006-05-01 00:00:00

  • [Use of monoclonal antibodies in prophylaxis and treatment of acute and chronic graft-versus-host disease in 2011].

    abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice of hematologic malignancies. Acute graft versus host disease (GvHD) is common after HSCT and directly related to graft versus leukemia effect. Little progress has been done in the treatment of acute GvHD. The first line treatment is u...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2011.1410

    authors: Xhaard A,Hermet E,Bay JO,Peffault de Latour R

    更新日期:2011-08-01 00:00:00

  • [Testicular germ cell tumors].

    abstract::Testicle germ cells tumors are the most common young men neoplasm. The incidence is maximal in Scandinavian countries. Cryptorchidism is a predisposing factor. Diagnosis is clinic, first treatment is radical orchidectomy by inguinal incision, after study of tumor markers. Histology shows seminoma or non seminomatous t...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Dourthe LM,Ouachet M,Fizazi K,Droz JP

    更新日期:1998-09-01 00:00:00

  • [Adult acute lymphoblastic leukemia with central nervous system involvement: an overview].

    abstract::At the time of diagnosis, central nervous system (CNS) involvement is identified in less than 10% of adult acute lymphoblastic leukemia (ALL). Long-term disease-free survival can be achieved in these patients. CNS disease at presentation does not appear to be an independent poor prognostic factor. In CNS leukemia, inn...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

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    authors: Thomas X,Pavan L,Le QH

    更新日期:2008-07-01 00:00:00

  • [Endometrial cancer and tamoxifen. Discussion apropos of a series of cases].

    abstract::Tamoxifen is widely used nowadays in the management of breast cancer, having established its efficacy in this indication, especially for postmenopausal patients with ER-positive breast tumours. However, tamoxifen has recently been recognized as carcinogenic for the human endometrium, probably with an effect of duratio...

    journal_title:Bulletin du cancer

    pub_type: 临床试验,杂志文章,多中心研究,评审

    doi:

    authors: Sasco AJ,Ah-Song R,Gendre I,Zlatoff P,Bobin JY,Hallonet P,Leduc B

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  • [Treatment of metastatic kidney neoplasms with a new interleukin 2 protocol: The experience of the Gustave-Roussy Institute].

    abstract::Treatment of metastatic renal cell carcinoma with interleukin 2 (IL2) remains controversial despite the authorization from the French government for IL2 with the West schedule in this disease. We report herein the study of the Institute Gustave-Roussy of 73 patients, who received from 1989 to 1991 a new schedule of hi...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Escudier B,Farace F,Théodore C,Angevin E,Court B,Couanet D,Dietrich PY,Culine S,Pallardy M,Hercend T

    更新日期:1995-04-01 00:00:00

  • [Intra-operative radiation therapy in tumors of the digestive tract].

    abstract::All the retrospective and prospective studies concerning IORT in tumors of the digestive tract tend to substantiate a significant improvement in local control without a significant increase in survival. Improvements in the results of IORT can be expected in the near future, and may occur on several fronts: - Technolog...

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    pub_type: 杂志文章,评审

    doi:

    authors: Dubois JB

    更新日期:2001-02-01 00:00:00