Abstract:
:Serotonin (5-Hydroxytryptamine) seems to play a dominant role in triggering vomiting induced by cytotoxic agents through the stimulation of 5-HT3 receptors. They have been observed in the GI tract as well as in the brain (area postrema). Ondansetron is a specific antagonist of 5-HT3 serotonin receptors. Its anti-emetic activity is very powerful in the ferret. The availability of an injectable or oral form of this product allows the overall treatment of acute and delayed emesis and its administration is in accordance with different schedules: single IV injection or a continuous 24 hour infusion or repeated IV injection followed by oral treatment. The pharmacokinetics of the drug are as follows: absorption begins about 30 minutes after the administration per os, its biodisponibility is about 60%, its clearance: 20 ml/minute and its elimination half life about 3 hours. Different double blind studies, carried out in parallel groups or in cross over, demonstrated the superiority of ondansetron over metoclopramide in the control of nausea and vomiting, whether or not the chemotherapy contained cisplatin; a more recent study shows also that ondansetron was superior to alizapride and methylprednisolone in combination. Side effects of ondansetron do not include extrapyramidal symptoms but only headaches and constipation. The use of ondansetron improves the well-being of patients receiving chemotherapy and increases protocol compliance.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
d'Allens H,Aubert B,Bons J,Pappo Msubject
Has Abstractpub_date
1991-01-01 00:00:00pages
1139-46issue
12eissn
0007-4551issn
1769-6917journal_volume
78pub_type
杂志文章,评审abstract:INTRODUCTION:The French Patient Advocacy Group SOS Desmoid conducted a survey to measure the pain burden of desmoid tumor patients. MATERIAL AND METHODS:We used a structured questionnaire to measure the occurrence and consequences of pain. RESULTS:The pain occurrence was approximately 63%. In one-third of the cases, ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2015.02.001
更新日期:2015-03-01 00:00:00
abstract::The authors analyse 123 cases of carcinoma of the uterine cervix treated by radiotherapy, with CEA radio-immuno-assay performed before treatment then each time patients are seen in follow-up. The CEA level is positive in 35 per cent of the cases with a mean value of 21 per cent for stage I, 36 per cent for stage II an...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::According to the point 7.6 and 7.7 of the Cancer Plan 2014, all cancer patients should have access to supportive care. Indeed, the supportive care consultation in oncology is an important tool for the symptom management of cancer patients at all times of treatment. This consultation can be mono-disciplinary or multi-d...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2015.04.019
更新日期:2015-09-01 00:00:00
abstract::The epidemiology of cancers is known in France through mortality data provided by Inserm and morbidity data obtained by French tumor registries. The purpose of this study was to compare the incidence of laryngeal cancers in 9 French departments and to give an estimate of this incidence for the whole of France, based o...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract::Gangliosides are glycosphingolipids which contain neuraminic acid. Although they are present in the plasma membranes of all cells, gangliosides are expressed differently, both quantitatively and qualitatively, in certain types of cancer. Modifications in ganglioside composition may account for some of the abnormal int...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1991-01-01 00:00:00
abstract::Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is now an entire part of treatment of peritoneal dissemination of colorectal malignancy, and it's possible to hope prolonged survival. This treatment is more and more codified. Four indications are recognized by some tree national evaluation committees: ...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2008.0553
更新日期:2008-01-01 00:00:00
abstract::We have previously shown that the addition of 4-methylthio-2-oxobutanoate (MTOB) to cultures of methionine dependent neoplastic cells which lack endogenous MTOB restores their capacity to grow in the absence of exogenous methionine. Transition state inhibitors of the MTOB transaminase,responsible for the transaminatio...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract::In order to help the clinician, mathematical models including several clinical and pathological variables are proposed in the literature with the aim to predict the occurrence of an event of interest. Nomograms allow individual prognosis for each patient. When they are developed, validated and correctly used, nomogram...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2017.10.024
更新日期:2018-01-01 00:00:00
abstract:CONTEXT:Survival of children, adolescents and young adults treated for cancer increased with improved treatments. But there is still an increased risk of second primary cancer (SPC) in the long term compared to the population of the same age, especially related to treatments. A reflection on the follow-up of this popul...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2015.03.017
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:The diagnosis of chronic myeloid leukemia is based on the presence of translocation t(9,22). Additional cytogenetic abnormalities may exist at diagnosis and have prognostic value. The authors evaluated the relationship between these additional chromosomal abnormalities, clinical presentation, and therapeut...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/j.bulcan.2019.03.013
更新日期:2019-06-01 00:00:00
abstract::Bladder tumours are frequent with around 10,000 new cases each year in France. Less than 500 of these cases are not transitional cell carcinoma, the most frequent pathological aspect. The identification of these pathological patterns requires an initial biopsy through transurethral resection. Sarcomatoid, squamous and...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2010.1097
更新日期:2010-01-01 00:00:00
abstract::The dependency between the risk of death and age is analysed, and the contribution of cancer to the overall risk of death is evaluated as a function of age. The frequency of the different cancer sites is described in different age groups. Lastly cancer mortality trends are presented by age. The risk of death from canc...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2007.0531
更新日期:2008-05-28 00:00:00
abstract::For two decades, the prognostic of adult patients with ALL was improved based on pediatric-inspired protocols. These approaches based on less myelosuppressive drugs have led to improved response rates, decreased relapse rates, with a benefit in survival observed in patients aged up to 50-60-years-old. Therapeutic inte...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2020.07.008
更新日期:2020-09-24 00:00:00
abstract::The aims of this study was to estimate and describe the reasons of use of complementary medicine in patients with a cancer treated in a French oncology department. An anonymous questionnaire was proposed to patients during treatment or follow-up in an oncology department. It was a descriptive study over 207 questionna...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::In response to the evolution of the information-seeking behaviour of patients and concerns from health professionals regarding cancer patient information, the French National Federation of Comprehensive Cancer Centres (FNCLCC) introduced, in 1998, an information and education program dedicated to patients and relative...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract::The first study evaluating directly by the referring physician the clinical impact of [18F]-FDG-PET on modification of patient's management was performed only recently in California by means of a questionnaire. We have used the same methodology to evaluate this clinical impact during the opening year of our PET centre...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::The study of mitotic transduction of the signal showed that overexpression of pAkt and reduction in pERK expression would be associated a biological relapse. For tumors T1-3 N0M0 at the high risk of local relapse after prostatectomy, an immediate radiotherapy compared with a differed radiotherapy (at the time of PSA r...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2005-10-01 00:00:00
abstract:FOCAL TREATMENT AND SYSTEMIC THERAPY IN METASTATIC KIDNEY CANCER:COMPLEMENTARY APPROACHES: To treat metastatic renal cell carcinoma, therapies used are with an oral intake, for the vast majority, and have many side effects that may compromise observance. Strategies of drug holiday have been studied and, in case of an i...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1016/S0007-4551(18)30376-X
更新日期:2018-12-01 00:00:00
abstract::Oncolor, network in oncology in Lorraine, was born ten years ago, from a group of professionals in the field of oncology who worked closed together with regional administrative authorities. Oncolor was created with respect of equilibrium between the different regional partners avoiding struggle for power. Oncolor was ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract::This article briefly outlines three major biochemical problems in relation to the presence of chemical carcinogens in mammalian cells: (a) the enzymatic systems responsible for the chemical carcinogen metabolism; (b) the nature of the reactive metabolites and (c) the cellular target(s). References and examples are onl...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Breast cancer remains a potentially lethal disease, which requires aggressive treatments and is associated with long-term consequences. Its prognosis is linked to both tumor biology and burden at diagnosis. Although treatments have allowed important improvements in prognosis over the past 20 years, breast cancer scree...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2016.06.005
更新日期:2016-09-01 00:00:00
abstract::Robotic assisted surgery is a new field of developing program for many specialties. As to head and neck oncology, the new procedure potentially offers alternatives to conventional surgery with decreased morbidity. The aim of this article is a description of the state of the art via a review of the literature. We empha...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2009.1022
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of [(18)F]-FDG PET/CT image fusion in the management of carcinomas of the upper aero-digestive tract. METHODS:This retrospective study included 169 patients with squamous cell cacinoma of the upper aerodigestive tract who underwent a PET/CT for : initial staging (n = 47), cervical lym...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::The antiestrogen tamoxifen (TAM) has been successfully used to treat breast cancer expressing estrogen and progesterone receptors (ER+ and PR+). However, the development of antiestrogen resistance is frequently observed in patients following long-term treatment. To better understand the mechanism of action of TAM and ...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:To assess the feasibility and efficacy of cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) without adjuvant chemotherapy for relapsed or persistent advanced ovarian cancer. METHODS:This observational study included stage IIIC ovarian cancer patients due to undergo CRS...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2010.1063
更新日期:2010-04-01 00:00:00
abstract::This study is devoted to the analysis of the surgical treatment of cancer of the uterine cervix, stage III. Three circumstances are evaluated: - Stage III with urinary disease the purpose of the surgical treatment is most often to save the renal function;--Recurrences after radiotherapy where surgery is the only poss...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::From 1941, estrogens are usually used in the treatment of prostatic carcinoma, wrongly in case of adjuvant hormonotherapy and exceedingly because of cardiovascular toxicity from over dosages. A recall of their mechanism of action and toxicity allows to argue about the palliative treatment and to look to their use for ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Genomic DNA displays a non canonical structure prone to be damaged and modified by genotoxic stresses, which are induced either by the endogenous metabolism or attacks from environment or therapeutic pressure. Several molecular pathways allow cells to repair such DNA lesions. Additional mechanisms have been selected t...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2010.1202
更新日期:2010-11-01 00:00:00
abstract::BRCA is a tumor suppressor gene implicated in the major mechanisms of cellular stability in every type of cell. Its mutations are described in numerous cancers, mainly breast and ovarian in women. It was also found an increase of lifetime risk of pancreas, colon, prostate cancer or lymphoma in men carriers. We report ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2014.1952
更新日期:2014-09-01 00:00:00
abstract::The objective of this study was to estimate the direct costs of invasive cervical cancer (ICC) management to the French national health insurance system the 1st year after ICC diagnosis. A retrospective survey was conducted in three centres in 2005, including 42 patients admitted for ICC between 2001-2003. Medical rec...
journal_title:Bulletin du cancer
pub_type: 杂志文章,多中心研究
doi:
更新日期:2007-02-01 00:00:00