Abstract:
BACKGROUND:Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) with a C8 to C18 chain length of alkyl groups. Since BAC exerts toxic effects on microorganisms, it has been used as an effective germicide and preservative, mostly in cosmetic industry and medicine. However, the toxic potential of BAC may be hazardous to humans, due to the common use of preparations containing BAC as a preservative. MATERIAL AND METHODS:To assess the possible toxic effects of BAC, two-stage experiments were performed on female Wistar rats. At first, LC50 after a single exposure to BAC aerosol was determined. Then, the animals were exposed to BAC aerosol at 30 mg/m3 for 6 h, and for 3 days (6 h/day). The controls were unexposed rats. Directly after BAC exposure and 18 h afterwards, BALF concentrations were measured of total protein, Clara cell protein, matrix metalloproteinase-9 (MMP-9), hyaluronic acid (HA), immunoglobulin E (IgE) and cytokines (TF-alpha, IL-6 and MIP-20), lactate dehydrogenase (LDH) and GSH-S-transferase (GST). RESULTS:The LC50 value for exposed rats was ca. 53 mg BAC in m3 air for 4 h. All the rats survived single and repeated inhalation exposure to 30 mg/m3 BAC. After single and repeated exposure, lung weight, total protein, HA and LDH activity in BALF of exposed rats were higher than in controls while CC16 levels were decreased. A significantly higher BALF concentration of IL-6 and IgE was noted in animals exposed to single and repeated doses. BALF concentrations of MMP-9, TNF-alpha, and MIP-2 in exposed rats were similar to those in control animals. CONCLUSION:BAC may be classified to class I acute inhalation toxicity. It showed a strong inflammatory and irritant activity on the lungs after 6h inhalation and stimulated dynamic patterns of IL-6 and IgE production and protein infiltration from blood vessels to BALF. Continued exposure resulted in cellular destruction, a statistically significant increase in LDH activity and a continuous decrease in CC16 concentration in BALF.
journal_name
Int J Occup Med Environ Healthauthors
Swiercz R,Hałatek T,Wasowicz W,Kur B,Grzelińska Z,Majcherek Wdoi
10.2478/v10001-008-0020-1subject
Has Abstractpub_date
2008-01-01 00:00:00pages
157-63issue
2eissn
1232-1087issn
1896-494Xpii
D95V4756006X0763journal_volume
21pub_type
杂志文章abstract::The 'Sendzimir' Steel Mill, Cracow, Poland, gives employment to approximately 17,000 workers. During the years 1994-98, 1396 compensation claims for diseases related to occupational hazards were registered. After a scrupulous investigation, 851 cases were certified as occupation-related diseases. Of this number, 481 c...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
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abstract::The aim of the present study was to investigate persistent neurobehavioural effects of repeated low-level exposure to chlorphenvinphos ((2-chloro-1-(2,4-dichlorophenyl) vinyl diethyl phosphate-CVP) in rats. The rats received 10 i.p. injections of CVP at daily doses of 0.5 mg/kg or 1.0 mg/kg (one injection/day, five da...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Regional differences in sick leave frequency and duration determinants were studied between different professions (sale and cleaning) in different regions in the Netherlands (Utrecht and South Limburg) and the influence of socio-cultural factors on those determinants was explored. MATERIALS AND METHODS:Empl...
journal_title:International journal of occupational medicine and environmental health
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doi:10.2478/v10001-008-0032-x
更新日期:2008-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00291
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To investigate the influence of the anti-tumor necrosis factor-α infliximab (IFX) in the case of rats with silicosis. MATERIAL AND METHODS:Forty-eight Wistar rats were randomly divided into 3 groups. The study group (N = 16) - silicosis was induced by intratracheal instillation of 50 mg silica on day 1, and...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01037
更新日期:2018-07-04 00:00:00
abstract::This study explores difficulties, supporting factors and benefits of networking to studied enterprises and other network partners (focus on OHS and client enterprises). The study also explores social capital as a resource produced in network relations, and trust as a core dimension of social capital, and trust as a bi...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was comparison of cancer incidence risk of lungs, stomach, colon, bladder and kidneys from ex-miners of black coal mines and the general male population of the Czech Republic. MATERIALS AND METHODS:The analysis was conducted in two cohorts of ex-miners according to the presence of coalwo...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/S13382-012-0015-9
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:The research purpose was to analyze data concerning chemical incidents in Poland collected in 1999-2009 in terms of health hazards. MATERIAL AND METHODS:The data was obtained, using multimodal information technology (IT) system, from chemical incidents reports prepared by rescuers at the scene. The final an...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00734
更新日期:2017-02-21 00:00:00
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journal_title:International journal of occupational medicine and environmental health
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doi:10.13075/ijomeh.1896.01457
更新日期:2019-11-15 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
abstract::Crystalline silica is a health hazard commonly encountered in work environment. Occupational exposure to crystalline silica dust concerns workers employed in such industries as mineral, fuel-energy, metal, chemical and construction industry. It is estimated that over 2 million workers in the European Union are exposed...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
doi:10.2478/v10001-008-0010-3
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Subchondral carpometacarpal cysts are classic and almost pathognomonic lesions found in workers using vibrating instruments over prolonged periods of time. MATERIALS AND METHODS:We present the case of a 53-year-old woman who worked for 30 years sewing shoe uppers, a task which required grasping firmly a pea...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-011-0042-y
更新日期:2011-12-01 00:00:00
abstract::A new agrarian policy in a number of countries caused the necessity to introduce additional measures aimed at preventing of agricultural workers' health. The epidemiological studies in the Ukraine revealed the prevalence of cardiovascular diseases (ischemic heart disease, arterial hypertension) particularly among oper...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVES:In Poland, occupational exposure to cold microclimate is quite common (5.1 workers/1000 occupationally active people). Reports on health effects of this exposure are rather scarce. The aim of the study was to evaluate the physiological reaction in workers occupationally exposed to cold microclimate. MATERIA...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/v10001-006-0020-y
更新日期:2006-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01274
更新日期:2019-02-27 00:00:00
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journal_title:International journal of occupational medicine and environmental health
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doi:10.2478/s13382-014-0266-8
更新日期:2014-06-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01045
更新日期:2018-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01115
更新日期:2018-01-07 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00121
更新日期:2015-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00920
更新日期:2018-01-07 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01262
更新日期:2018-12-20 00:00:00
abstract::The paper presents the results of geochemical investigations carried out in the city of Prague. Czech Republic, between the years 1994-1997, by the Czech Geological Institute, National Institute of Public Health and Hygiene Stations of Prague. Exposure assessment for children as the most sensitive population, based on...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Police officers run a risk of injury that is higher than in most other occupations. This study aims to quantify injury prevalence and identify common musculoskeletal injuries (MSIs) among police officers, using injury data from a municipal police service in Alberta, Canada. MATERIAL AND METHODS:This is a de...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01454
更新日期:2020-01-17 00:00:00
abstract:OBJECTIVES:The aim of this study is to assess chromosomal damage in Tunisian hospital workers occupationally exposed to low levels of ionizing radiation (IR). MATERIALS AND METHODS:The cytokinesis-block micronucleus (CBMN) assay in the peripheral lymphocytes of 67 exposed workers compared to 43 controls matched for ge...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,多中心研究
doi:10.2478/s13382-013-0084-4
更新日期:2013-03-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
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更新日期:2020-06-16 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
abstract::Many etiologies are held accountable for nasal septum perforations. Topical nasal drug usage, previous surgeries, trauma, nose picking, squamous cell carcinoma, some rheumatological disorders such as granulomatosis with polyangiitis (Wegener granulomatosis), some infectious diseases such as syphilis and leprosy are am...
journal_title:International journal of occupational medicine and environmental health
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doi:10.13075/ijomeh.1896.01019
更新日期:2017-10-06 00:00:00