Abstract:
:The aim of the present study was to investigate persistent neurobehavioural effects of repeated low-level exposure to chlorphenvinphos ((2-chloro-1-(2,4-dichlorophenyl) vinyl diethyl phosphate-CVP) in rats. The rats received 10 i.p. injections of CVP at daily doses of 0.5 mg/kg or 1.0 mg/kg (one injection/day, five days/week) which corresponded to 1/20 and 1/10 of LD50, respectively, for this species. In a part of the rats, cholinesterase (ChE) activity in blood (plasma and erythrocytes), and in the selected brain regions was determined at arbitrarily chosen time after the last exposure. The determinations showed that the level of ChE inhibition was dose-related, but the compartments studied differed in the magnitude of this effect. The differences in the level of ChE inhibition between the compartments were particularly evident in rats which had received CVP at the 1.0 mg/kg dose; in these animals 3 h after exposure the ChE activity in erythrocytes, plasma and the brain corresponded to 78%, 48% and 67-70%, respectively, of the control value. Enzyme activity returned to the control level after 14 days in plasma and after 35 days in erythrocytes. In rats receiving CVP at daily doses of 0.5 mg/kg, ChE activity in plasma was decreased by 40.8% and that in erythrocytes by 21.4% 3 h after the last exposure. The activity of ChE in plasma returned to the control level within four days and that in erythrocytes within 14 days. In these rats, in all the brain regions studied except brainstem, ChE activity was not reduced significantly. In rats selected for behavioural tests, the following behavioural aspects were investigated: response to novelty in an open field, acquisition and extinction of a one-way active avoidance response, and the magnitude and persistence of the footshock-induced analgesia (hot-plate test). Testing in the open field was performed before the exposure and then 1, 3 and 6 weeks after the last exposure. The remaining tests were performed after the exposure. The interval between testing and the last CVP injection was sufficient for recovery of ChE activity. It has been found that in rats of both exposure groups the response to novelty in the open field, i.e. the increase in locomotor and exploratory activity in the presence of a new object, was reduced, albeit nonsignificantly, compared to the unexposed animals. In rats which received CVP at the dose of 1.0 mg/kg, acquisition of the one-way active avoidance response was facilitated. No differences between groups were found during extinction of this response. In the hot-plate test, in rats exposed repeatedly to 1.0 mg/kg CVP, the footshock-induced increase in the latency of the paw-lick response to heat (54.5 degrees C) was stronger and more persistent than in the unexposed animals. The above results show that some neurobehavioural effects of exposure to organophosphorous (OP) compounds may be detected after a time sufficient for recovery of ChE activity.
journal_name
Int J Occup Med Environ Healthauthors
Soćko R,Gralewicz S,Górny Rsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
105-17issue
2eissn
1232-1087issn
1896-494Xjournal_volume
12pub_type
杂志文章abstract:OBJECTIVES:The objective of this work was to determine the dynamics of maximal anaerobic power (MAP) of the lower limbs, following a single whole body cryostimulation treatment (WBC), in relation to the temperature of thigh muscles. MATERIALS AND METHODS:The subjects included 15 men and 15 women with an average age (±...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-011-0017-z
更新日期:2011-06-01 00:00:00
abstract::A precise diagnosis of initial reticular forms of pneumoconioses is very difficult. The present study focuses on 30 patients with initial reticular forms of silicosis, asbestos induced interstitial lung fibrosis, mixed dust pneumoconioses and pneumoconioses of electrowelders. The anterior-posterior chest radiography (...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::We present the case of a subject developing anosmia, preceded by nasal transient irritation and short lasting phantosmia and torqosmia, upon re-entrance into a room treated with a pyrethrin-based insecticide. The concentration of the insecticide in the room is unknown, but relatively high levels are predicted basing u...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/S13382-012-0060-4
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely recognized as an occupational disease. The aim of the study has been to analyze the causes of the low p...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00920
更新日期:2018-01-07 00:00:00
abstract:OBJECTIVES:The aim of the study was to evaluate urinary mutagenicity in workers employed in a major chemical plant located near Rouen (France) that produces dichlorobenzidine and azo dyes. MATERIALS AND METHODS:Samples were obtained from 47 male workers aged 38.9+/-11.3 years (range, 21-58 years), mean duration of emp...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/v10001-007-0014-4
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:The objective of the study has been to assess the associations between psychological distress and exposure to workplace bullying, taking into account possible influence of adverse psychosocial job characteristics and occupational burnout in a sample of Kaunas (Lithuania) teachers. MATERIAL AND METHODS:The s...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00943
更新日期:2017-06-19 00:00:00
abstract::The effect of sodium fluoride on the content of adenine nucleotides, adenine nucleotide pool and energy potential of erythrocytes was studied in male Wistar rats, depending on the dose and time of exposure. Sodium fluoride was administered for 4 and 8 weeks at 4 or 16 ppm through a gastric tube. The concentration of f...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:Recovery processes in leisure time influence the effect of psychosocial work factors on health issues. However, this function of recovery has been neglected in research regarding the influence of work-related risk factors on low back pain (LBP) development. The aim of this prospective study was to examine th...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00861
更新日期:2017-03-30 00:00:00
abstract:OBJECTIVES:The risk of transmission of Mycobacterium tuberculosis from patients with tuberculosis to health care workers (HCWs) has been well documented but little is known about the prevalence of latent tuberculosis infection (LTBI) in Iranian HCWs. The aim of this study was to determine the prevalence of LTBI among H...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-011-0046-7
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to verify the influence of a specific exercise program on the strength and resistance levels of lumbar flexors and extensors in warehouse workers. MATERIALS AND METHODS:The population used in this randomized controlled trial included 557 warehouse male workers from a food distributi...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,随机对照试验
doi:10.2478/s13382-012-0011-0
更新日期:2012-03-01 00:00:00
abstract::An outline of the structure and operation principles of the database on EMF-producing devices used in Poland at frequencies ranging between 0.1 MHz and 300,000 MHz have been developed at the Nofer Institute of Occupational Medicine, Lodz. The primary objective of developing the EMF DATABASE is to ensure continuous and...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:Only a few studies have analyzed the health of self-employed workers. This cross-sectional study is the first to compare health status among craftsmen joiners and paid joiners. MATERIAL AND METHODS:Clinical and paraclinical data for self-employed craftsmen and employees were collected by occupational health...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-014-0261-0
更新日期:2014-06-01 00:00:00
abstract::Morphine is an opiate alkaloid characterized by various clinical effects, among which the most prominent are its analgesic and psychoactive effects. It also has a prominent depressive effect on the respiratory and cardiovascular system. Because of its psychoactive effect, morphine is very addictive and often used as a...
journal_title:International journal of occupational medicine and environmental health
pub_type:
doi:10.13075/ijomeh.1896.01629
更新日期:2021-01-07 00:00:00
abstract:OBJECTIVES:The study objective was to assess hydration status by measuring USG among construction workers in Iran. MATERIALS AND METHODS:The study design was comparative and experimental. Sixty participants were randomly selected from the construction workers from a construction campus with a similar type of work, cli...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-013-0143-x
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:Of all work stressors, occupational stress is the leading cause of many disorders among workers. Drivers are classified as a high risk group for work related stress. This study set out to determine the relationship between risk factors of cardiovascular diseases and occupational stress among drivers. MATERI...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00125
更新日期:2016-11-18 00:00:00
abstract::The study includes a detailed analysis of patients' exposure to ionising radiation resulting from diagnostic radiology in Poland. Data concerning the number and types of examinations were collected by wide-range questionnaire surveys conducted in 1986 and 1995. As the result, the number of examinations per 1000 inhabi...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::The presentation addresses current problems of health risk and health effects associated with exposure to asbestos, including data on historical exposure and on currently valid occupational exposure limits. The quantity and types of the raw material used for the production of various asbestos products have also been d...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-011-0020-4
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Methylnaphthalenes have been used extensively as chemical intermediates in organic synthesis, as solvents for pesticides, sulphur and various aromatic compounds. A wide use of methylnaphthalenes has contributed to their emission into the environment. The aim of the study was to explain the role of glutathion...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:This study has investigated the prevalence of work-related musculoskeletal disorders (WMSDs), the most commonly affected body parts, the risk factors of WMSDs and the coping strategies adopted by hairdressers. MATERIAL AND METHODS:The study design was a cross-sectional descriptive survey design. Two hundred...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00291
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:This study aims to assess muscle fatigue for kitchen workers during various tasks in a kitchen. MATERIAL AND METHODS:This study consists of 2 phases: a) surface electromyography (EMG) to determine muscle fatigue of trapezius and erector spinae muscles bilaterally for 12 healthy male volunteers during 30 min...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00903
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the potential association between occupational stress and musculoskeletal symptoms in firefighters. MATERIAL AND METHODS:Data were collected among Cypriot firefighters through a battery of adapted questionnaires completed anonymously. RESULTS:A total of 430 firefighter...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01268
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) with a C8 to C18 chain length of alkyl groups. Since BAC exerts toxic effects on microorganisms, it has been used as an effective germicide and preservative, mostly in cosmetic industry and medicine. However, the toxic potential of BAC may b...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/v10001-008-0020-1
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The aim of the research was to analyze the impact of selected factors: years of service, the number of interventions, self-efficacy and stress, on occupational burnout. It was hypothesized that firefighters with more years of service and a bigger number of interventions would be characterized by higher perce...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01483
更新日期:2020-04-30 00:00:00
abstract:OBJECTIVES:The correlation between quartz dust concentrations in the Swiss enterprises and the incidence of silicosis and other related diseases acknowledged as occupational diseases (OD) was investigated. MATERIAL AND METHODS:Quartz dust concentrations were obtained from Suva's databases of occupational health survei...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01272
更新日期:2018-10-23 00:00:00
abstract:OBJECTIVES:The method for the determination of As, Al, Cd, Ni, Pb (toxic elements) and Cr, Co, Cu, Fe, Mn, Zn (essential elements) in human urine by the use of Inductively Coupled Plasma Mass Spectrometry (quadrupole ICP-MS DRCe Elan, Perkin Elmer) with the dynamic reaction cell (DRC) was developed. MATERIALS AND METH...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-013-0106-2
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:In Poland, 95% of medical personnel had not received legal education before they completed their studies. Having been given these facts, we have started questioning legal awareness of people providing medical services. AIM OF THE STUDY:The study aimed at evaluating the knowledge of allergists and pulmonolog...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-013-0083-5
更新日期:2013-04-01 00:00:00
abstract::The HEALTH 21 policy for the European Region of WHO provides the framework for taking up the challenges of achieving better health by applying the best strategies that have emerged from the Region's collective experience during the past 10-15 years. The arguments contained within this new policy demonstrate the essent...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:One of the practical models for assessment of stressful working conditions due to job strain is "job demand and control" or Karasek's job strain model. This model explains how adverse physical and psychological effects including cardiovascular disease risk factors can be established due to high work demand. T...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-013-0127-x
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:The aim of the study was comparison of cancer incidence risk of lungs, stomach, colon, bladder and kidneys from ex-miners of black coal mines and the general male population of the Czech Republic. MATERIALS AND METHODS:The analysis was conducted in two cohorts of ex-miners according to the presence of coalwo...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/S13382-012-0015-9
更新日期:2012-06-01 00:00:00
abstract::Reactive oxygen species (ROS) are important causative factors of many lung diseases, for instance pulmonary emphysema, adult respiratory distress syndrome (ARDS), lung fibrosis or rejection of transplanted lung. Moreover, recent data show that these molecules also play some physiological roles including signal transdu...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00