Abstract:
OBJECTIVES:The aim of the study was to evaluate urinary mutagenicity in workers employed in a major chemical plant located near Rouen (France) that produces dichlorobenzidine and azo dyes. MATERIALS AND METHODS:Samples were obtained from 47 male workers aged 38.9+/-11.3 years (range, 21-58 years), mean duration of employment 9.0+/-8.7 years (range, 1-32 years) for urinary mutagenicity determination with use of the Ames fluctuation test (strains TA 98 and TA 100 with and without metabolic activation) and gas chromatography/mass spectrometry. To assess occupational exposure of workers, urine samples were collected in two series. First, initial just after a one-month holiday (non-exposure). Second, four months later during regular occupational activity. During the same periods, workers completed a questionnaire, which sought information concerning their working conditions, non-occupational factors, and personal habits. RESULTS:Of the total 47 samples tested, 3 (6%) collected just after a one-month holiday and 6 (12%) samples collected during regular occupational activity were positive in at least one mutagenicity assay. Dichlorobenzidine traces ranging from 1.6 to 8.9 ppb were detected in 4 (8%) samples of the exposed as well as in 4 (8%) samples of non-exposed workers. No significant differences between biological and analytical responses obtained in the non-exposure period and after occupational exposure were observed, however, 5 (11%) workers in this group presented urinary mutagenicity that could be related to occupational exposure. CONCLUSIONS:The study suggests that some industrial hygiene problems, revealed in the analysis of questionnaire responses and confirmed by our evaluation, could be undoubtedly and easily solved to improve working conditions of the employees.
journal_name
Int J Occup Med Environ Healthauthors
Guerbet M,Brisorgueuil E,Jolibois B,Caillard JF,Gehanno JFdoi
10.2478/v10001-007-0014-4subject
Has Abstractpub_date
2007-01-01 00:00:00pages
137-45issue
2eissn
1232-1087issn
1896-494Xpii
JR7642N807874878journal_volume
20pub_type
杂志文章abstract::This paper reviews the investigations of the effects of pre- and/or postnatal exposure to environmental tobacco smoke (ETS) on children health reported in the literature. The evidence from epidemiological studies demonstrate that children's exposure to ETS is a risk factor for a variety of diseases, including respirat...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study has been to analyze the epidemiological data on sharp injuries among health care workers before and after the implementation of regulations related to the conduct of the register of sharp injuries. MATERIAL AND METHODS:We hypothesized that the introduction of legislation would change th...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01045
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01073
更新日期:2017-10-06 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,meta分析,评审
doi:10.13075/ijomeh.1896.01074
更新日期:2017-05-08 00:00:00
abstract:OBJECTIVES:To evaluate: a) the prevalence of bilateral idiopathic carpal tunnel syndrome (CTS) in manual workers; b) a correlation between the duration of unilateral and bilateral CTS symptoms; c) a correlation between the onset of CTS symptoms in the unilateral dominant/non-dominant hand and the time of developing bil...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01517
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journal_title:International journal of occupational medicine and environmental health
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doi:10.2478/s13382-014-0310-8
更新日期:2014-10-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
doi:10.2478/v10001-009-0032-5
更新日期:2009-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
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journal_title:International journal of occupational medicine and environmental health
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journal_title:International journal of occupational medicine and environmental health
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doi:10.2478/s13382-014-0266-8
更新日期:2014-06-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.01340
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journal_title:International journal of occupational medicine and environmental health
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更新日期:1998-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
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journal_title:International journal of occupational medicine and environmental health
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doi:
更新日期:2003-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
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doi:10.13075/ijomeh.1896.01262
更新日期:2018-12-20 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-012-0054-2
更新日期:2012-09-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.13075/ijomeh.1896.00773
更新日期:2016-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
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doi:10.13075/ijomeh.1896.00861
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doi:10.2478/s13382-013-0106-2
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
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doi:10.13075/ijomeh.1896.01264
更新日期:2018-10-23 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:10.2478/s13382-013-0112-4
更新日期:2013-08-01 00:00:00
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::It is estimated that every third person living in Europe suffers from allergic diseases. Allergies are a growing health problem in Poland where 40% of the population have allergy symptoms, including 12% afflicted with asthma. The actual cost of allergic diseases is difficult to estimate due to the lack or incompletene...
journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章,评审
doi:10.13075/ijomeh.1896.01275
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journal_title:International journal of occupational medicine and environmental health
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journal_title:International journal of occupational medicine and environmental health
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doi:10.13075/ijomeh.1896.01454
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journal_title:International journal of occupational medicine and environmental health
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00