Abstract：
OBJECTIVES:Cyclophosphamide (CP) and ifosfamide (IF) are effective anti-cancer drugs but their genotoxicity can harm everyone contacting them occupationally or environmentally. Therefore, a sensitive method for monitoring their amounts in biological and environmental samples is needed. This has aimed to develop a method for analyzing these drugs in urine and water sewage samples. MATERIAL AND METHODS:The drug spiked samples were extracted, derivatized, and analyzed by gas chromatography-mass spectrometry and the analytical parameters were validated. RESULTS:The method gave linear calibration curves at the concentrations of 0-190 nmol/l. It had the quantitation limit of 3.8 nmol/l and showed acceptable specificity, accuracy, recovery and precision. CONCLUSIONS:The developed method can be used reliably for monitoring CP and IF concentrations in urine and water sewage. The method will be applied for preventing health risk from occupational and environmental exposures to these drugs. Int J Occup Med Environ Health 2016;29(5):815-822.
journal_name
Int J Occup Med Environ Healthauthors
Lekskulchai Vdoi
10.13075/ijomeh.1896.00773subject
Has Abstractpub_date
2016-01-01 00:00:00pages
815-22issue
5eissn
1232-1087issn
1896-494Xpii
60627journal_volume
29pub_type
杂志文章abstract：:After an introduction, giving a short historical perspective on European Health and Safety legislation, the first experiences and opportunities for occupational physicians regarding international co-operation are described, with the first result in a form of a Position Paper on Occupational Health, adopted by the Stan...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:A pumped storage power plant produces significant noise such that adjacent areas were deemed uninhabitable for the local population. In recent years, the population in the area has increased, and the noise levels are now causing significant distress to the local population. The company operating the power plant and a ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01361
更新日期：2019-06-14 00:00:00
abstract：OBJECTIVES:The research purpose was to analyze data concerning chemical incidents in Poland collected in 1999-2009 in terms of health hazards. MATERIAL AND METHODS:The data was obtained, using multimodal information technology (IT) system, from chemical incidents reports prepared by rescuers at the scene. The final an...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00734
更新日期：2017-02-21 00:00:00
abstract：OBJECTIVES:The objectives of this study have been to: 1) describe and compare urban and rural injured worker populations in Alberta, Canada; 2) identify return-to-work outcomes in urban and rural populations; 3) examine the relationship between geographic location of residence and recovery from work-related musculoskel...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00926
更新日期：2017-07-14 00:00:00
abstract：OBJECTIVES:The aim of this study is to assess chromosomal damage in Tunisian hospital workers occupationally exposed to low levels of ionizing radiation (IR). MATERIALS AND METHODS:The cytokinesis-block micronucleus (CBMN) assay in the peripheral lymphocytes of 67 exposed workers compared to 43 controls matched for ge...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,多中心研究
doi：10.2478/s13382-013-0084-4
更新日期：2013-03-01 00:00:00
abstract：:Neurotoxic and sensory respiratory irritation effects of 1-methylnaphthalene and 2-methylnaphthalene in male rats and male Balb/C mice were investigated under conditions of acute inhalation exposure. Rotarod performance and pain sensitivity behaviour were tested in rats exposed to 1-methylnaphthalene at concentrations...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:Police officers run a risk of injury that is higher than in most other occupations. This study aims to quantify injury prevalence and identify common musculoskeletal injuries (MSIs) among police officers, using injury data from a municipal police service in Alberta, Canada. MATERIAL AND METHODS:This is a de...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01454
更新日期：2020-01-17 00:00:00
abstract：OBJECTIVES:The objective of this work was to determine the dynamics of maximal anaerobic power (MAP) of the lower limbs, following a single whole body cryostimulation treatment (WBC), in relation to the temperature of thigh muscles. MATERIALS AND METHODS:The subjects included 15 men and 15 women with an average age (±...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-011-0017-z
更新日期：2011-06-01 00:00:00
abstract：:The paper describes an atypical case of simultaneous airborne and direct contact dermatitis in a beekeeper from the Małopolska region. This is the third such case described in a beekeeper in the world and the first in Poland. I suggest that propolis should be regarded as both a direct and airborne contact allergen in ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-012-0054-2
更新日期：2012-09-01 00:00:00
abstract：:Reactive oxygen species (ROS) are important causative factors of many lung diseases, for instance pulmonary emphysema, adult respiratory distress syndrome (ARDS), lung fibrosis or rejection of transplanted lung. Moreover, recent data show that these molecules also play some physiological roles including signal transdu...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVES:Work-related musculoskeletal disorders in the neck and shoulder regions are common among carpet weavers. Working for prolonged hours in a static and awkward posture could result in an increased muscle activity and may lead to musculoskeletal disorders. Ergonomic workstation improvements can reduce muscle fat...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00589
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:Recently more attention has been focused on the impact of physical activity on modification of self-perceived heath status in adults. The objective of the study was to evaluate the level of occupational and non-occupational physical activities and their correlation with self-perceived heath status among econ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-006-0005-x
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:This current study investigates the effect of lean management system on work attitudes of workers of two manufacturing companies. "Lean management" is a concept of work processes and human relations that determines company's productivity and profitability. Workers of two enterprises, the first one with lean ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/S13382-012-0044-4
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:The study aimed at measuring exhaled breath malondialdehyde (EBC-MDA) in workers exposed to dust containing silica and at its comparison with the non-exposed control group. MATERIAL AND METHODS:The cross sectional, case-control study (N = 50) was performed in a tile and ceramics production factory in Yazd...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00262
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:It is commonly known that ergonomics in emergency medical services (EMS) is very important. Emergency medical services workers are exposed to different conditions and they should perform a variety of tasks. MATERIAL AND METHODS:The aim of the work has been to analyze the angular position of elbows and force...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01073
更新日期：2017-10-06 00:00:00
abstract：:Breast cancer is responsible for considerable morbidity and the majority of female deaths in industrialized countries. In the etiology of breast cancer many endogenous and exogenous risk factors have been discussed. It is estimated that about 40% of all cancers in women are hormonally mediated. Both estrogens and andr...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:Abnormalities in the timing and course of spermatozoa capacitation and hyperactivation underlie common pathologies related to male infertility. Recent data shows that low frequency electromagnetic waves may influence cell membrane potential and permeability. It is therefore possible that low frequency electr...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01262
更新日期：2018-12-20 00:00:00
abstract：:Morphine is an opiate alkaloid characterized by various clinical effects, among which the most prominent are its analgesic and psychoactive effects. It also has a prominent depressive effect on the respiratory and cardiovascular system. Because of its psychoactive effect, morphine is very addictive and often used as a...
journal_title：International journal of occupational medicine and environmental health
pub_type：
doi：10.13075/ijomeh.1896.01629
更新日期：2021-01-07 00:00:00
abstract：OBJECTIVES:This article investigates sickness presence among secondary school students in 5 European countries. The research questions asked are: What characterizes students with high sickness presence in secondary schools? Does high sickness presence influence future sickness absence? MATERIAL AND METHODS:A group of ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01441
更新日期：2019-11-15 00:00:00
abstract：OBJECTIVES:The aim of the study was to recommend methods for assessing low frequency noise (LFN) in the occupational environment to prevent annoyance and its effects on work performance. Three different evaluating methods and corresponding admissible values were proposed: (i) method I--frequency analysis in 1/3-octave ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-006-0022-9
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:This study was designed to evaluate the immune status of health care workers against varicella zoster in a university hospital in Teheran, Iran, and to compare the history of chickenpox infection with the presence of varicella antibodies in this population. METHODS:Serologic testing for varicella was perfor...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-010-0011-x
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder that affects 1-2% of the adult population. People with OCD are more likely to report impaired social and occupational functioning. Although effective treatments of the OCD exist, many sufferers from this disorder are continuously misdiagnose...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00792
更新日期：2016-11-18 00:00:00
abstract：INTRODUCTION:It is still uncertain if having at least moderate physical fitness is a necessary and sufficient condition for lowering the risk of death. The aforementioned statement constituted the basis for undertaking the study concerning the effect of particular health-related behaviours on the likelihood of survival...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-013-0112-4
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:Vocal cord dysfunction (VCD) is an uncommon respiratory disease characterized by the paradoxical adduction of vocal cords during inspiration, that may mimic bronchial asthma. The pathogenesis of VCD has not been clearly defined but it is possible to recognize non-psychologic and psychologic causes. The major...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-009-0038-z
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:The risk of transmission of Mycobacterium tuberculosis from patients with tuberculosis to health care workers (HCWs) has been well documented but little is known about the prevalence of latent tuberculosis infection (LTBI) in Iranian HCWs. The aim of this study was to determine the prevalence of LTBI among H...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-011-0046-7
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVES:Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous and persistent environmental pollutants and food contaminants. Both are neurotoxic, especially for the developing nervous system. MATERIAL AND METHODS:Female rats were exposed from day 7 of pregnancy up to day 21 after the delivery to ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-009-0015-6
更新日期：2009-01-01 00:00:00
abstract：:The study aimed at assessing cancer risk in a cohort of workers employed in the rubber tire production. The cohort consisted of 17,747 workers (11,660 men and 6087 women) employed in a rubber tire plant for at least three months during the years 1950-1995. The cohort follow-up was completed on December 31, 1995. Death...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVES:To describe blood lead (Pb-B), cadmium (Cd-B) and mercury (Hg-B) levels in children living in urban, industrial and rural areas in Fez city (north of Morocco) and to identify the determinants and some renal effects of exposure. MATERIAL AND METHODS:The study was conducted from June 2007 to January 2008 in 2...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-014-0275-7
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:The aim of the study was comparison of cancer incidence risk of lungs, stomach, colon, bladder and kidneys from ex-miners of black coal mines and the general male population of the Czech Republic. MATERIALS AND METHODS:The analysis was conducted in two cohorts of ex-miners according to the presence of coalwo...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/S13382-012-0015-9
更新日期：2012-06-01 00:00:00
abstract：:Effects of combined exposure to m-xylene and n-butyl alcohol in the conditions of subchronic inhalation experiment in rats were examined. Rats were exposed to vapours of individual solvents at concentrations of 50 and 100 ppm and their 1:1 mixture at concentrations of 50 + 50 ppm and 100 + 100 ppm, 6 h/day, 5 days/wee...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
