当前位置： SCI文献检索 > International Journal of Occupational Medicine and Environmental Health期刊下所有文献 > The role of glutathione in metabolism of selected dimethylnaphthalenes in rat.

The role of glutathione in metabolism of selected dimethylnaphthalenes in rat.

Abstract：

OBJECTIVES:Methylnaphthalenes have been used extensively as chemical intermediates in organic synthesis, as solvents for pesticides, sulphur and various aromatic compounds. A wide use of methylnaphthalenes has contributed to their emission into the environment. The aim of the study was to explain the role of glutathione in metabolism of selected dimethylnaphthalenes in rat. MATERIALS AND METHODS:The experiments were conducted on male rats of the strain outbred IMP:WIST The animals were administered a single intraperitoneal dose (600 mg/kg body weight) of dimethylnaphthalenes (1,2-DMN; 1,3-DMN; 1,4-DMN) or dimethylnaphthalenes-[ring-U-3H]: (1,2-DMN-[3H]; 1,3-DMN-[3H]; 1,4-DMN-[3H]). The analysis was performed after 4, 8, 24, 48 h. The biochemical parameters were indicated: hepatic and pulmonary GSH, a-GST, SDH, GPX in blood, and adduct levels in the liver and lung. RESULTS:The investigations demonstrated that a single intraperitoneal administration of dimethylnaphthalenes to rats at a dose of 600 mg/kg body weight caused a substantial depletion of reduced glutathione (GSH) level both in the liver and lung. The activity of a-glutathione S-transferases in serum of experimental animals exposed to dimethylnaphthalenes increased only after 1,2-DMN administration, the compound for which in earlier investigations the largest number of sulphur-containing metabolites was found in urine. To evidence that deep GSH depletion in analyzed organs has no oxidative nature, glutathione peroxidase activity in blood was determined. CONCLUSIONS:Lack of changes in glutathione peroxidase and sorbitol dehydrogenase activity for all the investigated compounds suggests that significantly deep GSH depletion in liver was not of oxidative nature and did not lead to necrotic changes in produced metabolites binding with GSH.

journal_name

Int J Occup Med Environ Health

journal_title

International journal of occupational medicine and environmental health

authors

Kilanowicz A,Sapota A,Daragó A

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

265-70

issue

3

eissn

1232-1087

issn

1896-494X

journal_volume

16

pub_type

杂志文章

相关文献

International Journal of Occupational Medicine and Environmental Health文献大全
  • Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis.

    abstract：:The role of glutathione S-transferase Mu 1 (GSTM1) in the biomonitoring of polycyclic aromatic hydrocarbons (PAHs) is not clear. Our purpose has been to evaluate the influence of GSTM1 genotypes on 1-hydroxypyrene (1-OHP), deoxyribonucleic acid (DNA) adducts, and micronucleus frequency in both occupational and non-occ...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章,meta分析,评审

    doi：10.13075/ijomeh.1896.01054

    authors： Li D,Wang B,Feng G,Xie M,Wang L,Gao R

    更新日期：2017-03-30 00:00:00

  • Self-employment in joinery: an occupational risk facor?

    abstract：OBJECTIVES:Only a few studies have analyzed the health of self-employed workers. This cross-sectional study is the first to compare health status among craftsmen joiners and paid joiners. MATERIAL AND METHODS:Clinical and paraclinical data for self-employed craftsmen and employees were collected by occupational health...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-014-0261-0

    authors： Lesage FX,Salles J,Deschamps F

    更新日期：2014-06-01 00:00:00

  • Psychosocial and organizational work environment of nurse managers and self-reported depressive symptoms: cross-sectional analysis from a cohort of nurse managers.

    abstract：OBJECTIVES:The association between depressive symptoms and psycho-organisational work environment has been established in the literature. Some studies have evaluated depressive symptoms in healthcare workers, but little research has been carried out among nurse managers. The aim of the study is to evaluate the depressi...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-014-0264-x

    authors： Nourry N,Luc A,Lefebvre F,Sultan-Taïeb H,Béjean S

    更新日期：2014-04-01 00:00:00

  • Effect of a specific exercise program on the strength and resistance levels of lumbar muscles in warehouse workers.

    abstract：OBJECTIVE:The aim of this study was to verify the influence of a specific exercise program on the strength and resistance levels of lumbar flexors and extensors in warehouse workers. MATERIALS AND METHODS:The population used in this randomized controlled trial included 557 warehouse male workers from a food distributi...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章,随机对照试验

    doi：10.2478/s13382-012-0011-0

    authors： Carvalho Mesquita C,Ribeiro JC,Moreira P

    更新日期：2012-03-01 00:00:00

  • Silicosis in Switzerland.

    abstract：OBJECTIVES:The correlation between quartz dust concentrations in the Swiss enterprises and the incidence of silicosis and other related diseases acknowledged as occupational diseases (OD) was investigated. MATERIAL AND METHODS:Quartz dust concentrations were obtained from Suva's databases of occupational health survei...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.13075/ijomeh.1896.01272

    authors： Koller MF,Scholz SM,Pletscher C,Miedinger D

    更新日期：2018-10-23 00:00:00

  • Effects of GSM signals during exposure to event related potentials (ERPs).

    abstract：OBJECTIVES:The primary aim of this work was to assess the effect of electromagnetic field (EMF) from the GSM mobile phone system on human brain function. The assessment was based on the assay of event related potentials (ERPs). MATERIAL AND METHODS:The study group consisted of 15 volunteers, including 7 men and 8 wome...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/v10001-010-0021-8

    authors： Bak M,Dudarewicz A,Zmyślony M,Sliwinska-Kowalska M

    更新日期：2010-01-01 00:00:00

  • Cancer mortality in rubber tire workers in Poland.

    abstract：:The study aimed at assessing cancer risk in a cohort of workers employed in the rubber tire production. The cohort consisted of 17,747 workers (11,660 men and 6087 women) employed in a rubber tire plant for at least three months during the years 1950-1995. The cohort follow-up was completed on December 31, 1995. Death...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：

    authors： Wilczyńska U,Szadkowska-Stańczyk I,Szeszenia-Dabrowska N,Sobala W,Strzelecka A

    更新日期：2001-01-01 00:00:00

  • Effect of individual finger skin temperature on vibrotactile perception threshold.

    abstract：OBJECTIVES:In healthy people, the vibrotactile perception threshold (VPT) at fingertips depends on a given measurement method and on individual characteristics such as age, gender and finger skin temperature. The aim of the study was to compare the VPT values in 2 groups of healthy subjects with different finger skin t...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-013-0163-6

    authors： Harazin B,Harazin-Lechowska A,Kałamarz J

    更新日期：2013-12-01 00:00:00

  • Early developmental effects of separate or combined perinatal exposure to methylmercury (MeHg) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in the rat.

    abstract：OBJECTIVES:Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous and persistent environmental pollutants and food contaminants. Both are neurotoxic, especially for the developing nervous system. MATERIAL AND METHODS:Female rats were exposed from day 7 of pregnancy up to day 21 after the delivery to ...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/v10001-009-0015-6

    authors： Sitarek K,Gralewicz S

    更新日期：2009-01-01 00:00:00

  • Exposure to environmental tobacco smoke and children health.

    abstract：:This paper reviews the investigations of the effects of pre- and/or postnatal exposure to environmental tobacco smoke (ETS) on children health reported in the literature. The evidence from epidemiological studies demonstrate that children's exposure to ETS is a risk factor for a variety of diseases, including respirat...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章,评审

    doi：

    authors： Tutka P,Wielosz M,Zatoński W

    更新日期：2002-01-01 00:00:00

  • Assessment of construction workers' hydration status using urine specific gravity.

    abstract：OBJECTIVES:The study objective was to assess hydration status by measuring USG among construction workers in Iran. MATERIALS AND METHODS:The study design was comparative and experimental. Sixty participants were randomly selected from the construction workers from a construction campus with a similar type of work, cli...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-013-0143-x

    authors： Montazer S,Farshad AA,Monazzam MR,Eyvazlou M,Yaraghi AA,Mirkazemi R

    更新日期：2013-10-01 00:00:00

  • Assessment of shoulder and low back muscle activity of male kitchen workers using surface electromyography.

    abstract：OBJECTIVES:This study aims to assess muscle fatigue for kitchen workers during various tasks in a kitchen. MATERIAL AND METHODS:This study consists of 2 phases: a) surface electromyography (EMG) to determine muscle fatigue of trapezius and erector spinae muscles bilaterally for 12 healthy male volunteers during 30 min...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.13075/ijomeh.1896.00903

    authors： Subramaniam S,Murugesan S,Jayaraman S

    更新日期：2018-01-01 00:00:00

  • Protecting and promoting mental health of nurses in the hospital setting: Is it cost-effective from an employer's perspective?

    abstract：OBJECTIVES:Nurses are at elevated risk of burnout, anxiety and depressive disorders, and may then become less productive. This begs the question if a preventive intervention in the work setting might be cost-saving from a business perspective. MATERIAL AND METHODS:A cost-benefit analysis was conducted to evaluate the ...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章,随机对照试验

    doi：10.13075/ijomeh.1896.00465

    authors： Noben C,Evers S,Nieuwenhuijsen K,Ketelaar S,Gärtner F,Sluiter J,Smit F

    更新日期：2015-01-01 00:00:00

  • Influenece of the CPRmeter on angular position of elbows and generated forces during cardiopulmonary resuscitation.

    abstract：OBJECTIVES:It is commonly known that ergonomics in emergency medical services (EMS) is very important. Emergency medical services workers are exposed to different conditions and they should perform a variety of tasks. MATERIAL AND METHODS:The aim of the work has been to analyze the angular position of elbows and force...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.13075/ijomeh.1896.01073

    authors： Kopacz K,Fronczek-Wojciechowska M,Jaźwińska A,Padula G,Nowak D,Gaszyński T

    更新日期：2017-10-06 00:00:00

  • Occupational exposure to particulate matter in 2 Portuguese waste-sorting units.

    abstract：OBJECTIVES:This study intended to characterize work environment contamination by particles in 2 waste-sorting plants. MATERIAL AND METHODS:Particles were measured by portable direct-reading equipment. Besides mass concentration in different sizes, data related with the number of particles concentration were also obtai...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-014-0310-8

    authors： Viegas S,Almeida-Silva M,Viegas C

    更新日期：2014-10-01 00:00:00

  • Screening survey of ocular, nasal, respiratory and skin symptoms in manicurists in Poland.

    abstract：OBJECTIVES:Manicurists are exposed to various chemicals in nail and skin care products and may develop ocular, nasal, respiratory or skin adverse reactions to them. To investigate the occurrence of ocular, nasal, respiratory and skin problems among manicurists and to identify their causal factors, particularly allergic...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.13075/ijomeh.1896.00961

    authors： Kieć-Świerczyńska M,Świerczyńska-Machura D,Chomiczewska-Skóra D,Kręcisz B,Walusiak-Skorupa J

    更新日期：2017-10-06 00:00:00

  • Commentary: barriers and opportunities to changing the research agenda to support precaution and primary prevention.

    abstract：:Conceptual research to define the Precautionary Principle and its role in science, science policy, and public health is making substantial progress. In September 2001, participants at the International Summit on Science and the Precautionary Principle developed a vision for science to address the complexity of contemp...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章,评审

    doi：

    authors： Tickner JA

    更新日期：2004-01-01 00:00:00

  • Repeatability of vibrotactile perception thresholds obtained with two different measuring systems.

    abstract：OBJECTIVES:The measurement of vibrotactile perception thresholds (VPTs) on the workers' fingertips is one of the diagnostic methods of the occupational peripheral neuropathies. The aim of the study was to compare the repeatability of VPT measurements in two groups of healthy women with different finger skin temperature...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：

    authors： Harazin B,Kuprowski J,Stolorz G

    更新日期：2003-01-01 00:00:00

  • Road ambulances: working conditions of paramedics - pilot studies.

    abstract：OBJECTIVES:The article presents the results of selected pilot studies conducted in medical ambulances. Their aim was to determine the working conditions and identify troublesome factors accompanying the performance of basic medical procedures by rescue teams. MATERIAL AND METHODS:The study of working conditions was ca...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.13075/ijomeh.1896.01479

    authors： Bęczkowska S,Grabarek I,Pilip S,Szpakowski L,Gałązkowski R

    更新日期：2020-01-17 00:00:00

  • Multi-element analysis of urine using dynamic reaction cell inductively coupled plasma mass spectrometry (ICP-DRC-MS) - a practical application.

    abstract：OBJECTIVES:The method for the determination of As, Al, Cd, Ni, Pb (toxic elements) and Cr, Co, Cu, Fe, Mn, Zn (essential elements) in human urine by the use of Inductively Coupled Plasma Mass Spectrometry (quadrupole ICP-MS DRCe Elan, Perkin Elmer) with the dynamic reaction cell (DRC) was developed. MATERIALS AND METH...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-013-0106-2

    authors： Brodzka R,Trzcinka-Ochocka M,Janasik B

    更新日期：2013-04-01 00:00:00

  • The influence of single whole body cryostimulation treatment on the dynamics and the level of maximal anaerobic power.

    abstract：OBJECTIVES:The objective of this work was to determine the dynamics of maximal anaerobic power (MAP) of the lower limbs, following a single whole body cryostimulation treatment (WBC), in relation to the temperature of thigh muscles. MATERIALS AND METHODS:The subjects included 15 men and 15 women with an average age (±...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-011-0017-z

    authors： Klimek AT,Lubkowska A,Szyguła Z,Frączek B,Chudecka M

    更新日期：2011-06-01 00:00:00

  • The bilaterality of idiopathic carpal tunnel syndrome among manual workers.

    abstract：OBJECTIVES:To evaluate: a) the prevalence of bilateral idiopathic carpal tunnel syndrome (CTS) in manual workers; b) a correlation between the duration of unilateral and bilateral CTS symptoms; c) a correlation between the onset of CTS symptoms in the unilateral dominant/non-dominant hand and the time of developing bil...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.13075/ijomeh.1896.01517

    authors： Lewańska M

    更新日期：2020-03-13 00:00:00

  • The psychosocial factors at work related to depression among female white-collar workers in Vilnius (Lithuania).

    abstract：OBJECTIVES:The aim of this study is to establish which psychosocial factors at work are related to depression among female white-collar workers in Vilnius. MATERIALS AND METHODS:The data was collected in a case-control study in 2002-2004. The cases were selected from patients treated at Vilnius mental health centers. ...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-011-0018-y

    authors： Stanislavoviene J,Pajarskiene B,Jankauskas R,Veniute M

    更新日期：2011-06-01 00:00:00

  • Comparing the performance of QuantiFERON-TB Gold and Mantoux test in detecting latent tuberculosis infection among Iranian health care workers.

    abstract：OBJECTIVES:The risk of transmission of Mycobacterium tuberculosis from patients with tuberculosis to health care workers (HCWs) has been well documented but little is known about the prevalence of latent tuberculosis infection (LTBI) in Iranian HCWs. The aim of this study was to determine the prevalence of LTBI among H...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-011-0046-7

    authors： Talebi-Taher M,Javad-Moosavi SA,Entezari AH,Shekarabi M,Parhizkar B

    更新日期：2011-12-01 00:00:00

  • Cytostatics as hazardous chemicals in healthcare workers' environment.

    abstract：:Cytostatics not only induce significant side-effects in patients treated oncologically but also pose a threat to the health of occupationally exposed healthcare workers: pharmacists, physicians, nurses and other personnel. Since the 1970s numerous reports from various countries have documented the contamination of wor...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章,评审

    doi：10.13075/ijomeh.1896.01248

    authors： Pałaszewska-Tkacz A,Czerczak S,Konieczko K,Kupczewska-Dobecka M

    更新日期：2019-04-03 00:00:00

  • The use of Spielberger's State-Trait Personality Inventory (trait anxiety subscale) with naval subaquatic specialists.

    abstract：OBJECTIVES:Panic behavior poses a particular threat to the health and safety of subaquatic occupational specialists. Trait anxiety has previously been identified as a marker of panic behavior under water, and Spielberger's State-Trait Personality Inventory (trait anxiety subscale) has been previously used to measure tr...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/s13382-014-0321-5

    authors： Van Wijk CH

    更新日期：2014-12-01 00:00:00

  • Cardiogenic shock induced by a high dose of intravenous morphine.

    abstract：:Morphine is an opiate alkaloid characterized by various clinical effects, among which the most prominent are its analgesic and psychoactive effects. It also has a prominent depressive effect on the respiratory and cardiovascular system. Because of its psychoactive effect, morphine is very addictive and often used as a...

    journal_title：International journal of occupational medicine and environmental health

    pub_type：

    doi：10.13075/ijomeh.1896.01629

    authors： Sein Anand Ł,Korolkiewicz PK,Sein Anand J

    更新日期：2021-01-07 00:00:00

  • Occupational exposure and malignant lymphoma.

    abstract：:The incidence of malignant lymphoma, especially non-Hodgkin's lymphoma has increased over the last few decades. This statement is true despite the fact that methods for diagnosing malignant lymphoma have changed and misclassification has become a problem. The present review is mainly concerned with occupational aspect...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章,评审

    doi：

    authors： Persson B

    更新日期：1996-01-01 00:00:00

  • Irritant vocal cord dysfunction and occupational bronchial asthma: differential diagnosis in a health care worker.

    abstract：OBJECTIVES:Vocal cord dysfunction (VCD) is an uncommon respiratory disease characterized by the paradoxical adduction of vocal cords during inspiration, that may mimic bronchial asthma. The pathogenesis of VCD has not been clearly defined but it is possible to recognize non-psychologic and psychologic causes. The major...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.2478/v10001-009-0038-z

    authors： Tonini S,Dellabianca A,Costa C,Lanfranco A,Scafa F,Candura SM

    更新日期：2009-01-01 00:00:00

  • Spirometric and hygienic criteria in recognition of occupational COPD in Poland - A retrospective analysis of medical records.

    abstract：OBJECTIVES:Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely recognized as an occupational disease. The aim of the study has been to analyze the causes of the low p...

    journal_title：International journal of occupational medicine and environmental health

    pub_type： 杂志文章

    doi：10.13075/ijomeh.1896.00920

    authors： Kleniewska A,Walusiak-Skorupa J,Lipińska-Ojrzanowska A,Szcześniak K,Wiszniewska M

    更新日期：2018-01-07 00:00:00