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A bivalent influenza VLP vaccine confers complete inhibition of virus replication in lungs.

Abstract：

:The conventional egg-grown influenza vaccines are trivalent. To test the feasibility of using multivalent influenza virus-like particles (VLPs) as an alternative influenza vaccine, we developed cell-derived influenza VLPs containing the hemagglutinin (HA) of the H1 subtype virus A/PR/8/34 or the H3 subtype virus A/Aichi/2/68 (X31). Mice immunized intramuscularly with bivalent influenza VLPs containing H1 and H3 HAs induced neutralizing activities against the homologous and closely related H1N1 strains A/PR/8/34 and A/WSN/33 as well as the H3N2 strains A/Aichi/2/68 (X31) and A/Hong Kong/68, but not the A/Philippines/2/82 strain isolated 14 years later. HA sequence and structure analysis indicated that antigenic distance could be a major factor in predicting cross-protection by VLP vaccines. The bivalent influenza VLP vaccine demonstrated advantages in broadening the protective immunity after lethal challenge infections when compared to a monovalent influenza VLP vaccine. High levels of the inflammatory cytokine IL-6 were observed in naïve or unprotected immunized mice but not in protected mice upon lethal challenge. These results indicate that multivalent influenza VLP vaccines can be an effective antigen for developing safe and alternative vaccine to control the spread of influenza viruses.

journal_name

Vaccine

journal_title

Vaccine

authors

Quan FS,Steinhauer D,Huang C,Ross TM,Compans RW,Kang SM

doi

10.1016/j.vaccine.2008.03.055

subject

Has Abstract

pub_date

2008-06-19 00:00:00

pages

3352-61

issue

26

eissn

0264-410X

issn

1873-2518

pii

S0264-410X(08)00387-3

journal_volume

26

pub_type

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