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A novel sesquiterpene lactone from Centaurea pullata: structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties.

Abstract：

:A novel elemanolide with an alpha-methyl-gamma-lactone moiety, 8alpha-O-(4-hydroxy-2-methylenebutanoyloxy)melitensine, in addition to four known sesquiterpene lactones also bearing the same lactone ring, melitensin, 11beta,13 dihydrosalonitenolide, 8alpha-hydroxy-11beta,13-dihydro-4-epi-sonchucarpolide, and 8alpha-hydroxy-11beta,13-dihydro-onopordaldehyde have been isolated from the aerial parts of Centaurea pullata. The in vitro antibacterial and antifungal activities of the isolated sesquiterpene lactones were tested against six bacteria and eight fungal species, using a microdilution method. All compounds tested showed greater antibacterial and antifungal activities than the positive controls used. Moreover, the pharmacokinetic profile of these compounds was investigated using computational methods.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Djeddi S,Karioti A,Sokovic M,Koukoulitsa C,Skaltsa H

doi

10.1016/j.bmc.2008.01.056

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

3725-31

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00093-X

journal_volume

16

pub_type

杂志文章

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