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Synthesis of curcumin mimics with multidrug resistance reversal activities.

Abstract：

:In order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Um Y,Cho S,Woo HB,Kim YK,Kim H,Ham J,Kim SN,Ahn CM,Lee S

doi

10.1016/j.bmc.2008.02.012

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

3608-15

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00121-1

journal_volume

16

pub_type

杂志文章

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