Pharmacokinetic study of extradural and intrathecal sufentanil anaesthesia for major surgery.

abstract：BACKGROUND:Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish. The analgesic effects of TTX were investigated in different animal pain models. METHODS:Wistar rats were submitted to the formalin test and to partial ligation of the sciatic nerve (Seltzer's model). Swiss Webster mice w...

journal_title：British journal of anaesthesia

authors： Marcil J,Walczak JS,Guindon J,Ngoc AH,Lu S,Beaulieu P

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:To study adequate antinociception during general anaesthesia, tetanic stimulus of 5-10 s duration has been used previously as a standardized nociceptive stimulus. However, such stimuli have been found to correlate poorly with intraoperative nociception. We hypothesized that an electrical tetanic stimulus of ...

journal_title：British journal of anaesthesia

authors： Rantanen M,Yppärilä-Wolters H,van Gils M,Yli-Hankala A,Huiku M,Kymäläinen M,Korhonen I

更新日期：2007-10-01 00:00:00

abstract：:The Swedish Society of Anaesthetists conducted a nationwide retrospective survey of clinical experience with extradural and intrathecal opiates. Special interest was focused on the frequency and type of ventilatory depression. The questionnaire was answered by 84 of 93 departments (90%). Up to May 1981 extradural morp...

journal_title：British journal of anaesthesia

authors： Gustafsson LL,Schildt B,Jacobsen K

更新日期：1982-05-01 00:00:00

abstract：:We have compared bispectral index (BIS), 95% spectral edge frequency (SEF) and approximate entropy (ApEn) in 37 patients during induction and recovery from a short general anaesthetic. Heart rate variability (HRV) was also compared during induction only. These indices were noted at the start of induction, when a syrin...

journal_title：British journal of anaesthesia

authors： Sleigh JW,Donovan J

更新日期：1999-05-01 00:00:00

abstract：:Metoclopramide hastens emptying of the stomach. Since it may be given to patients before operation, the sedative and toxic effects of 10- and 20-mg does given i.m. were studied in patients and student volunteers. Saline and diazepam 10 mg were used as placebo and reference drugs. Neither dose of metoclopramide had as ...

journal_title：British journal of anaesthesia

authors： Dundee JW,Clarke RS,Howard PJ

更新日期：1974-07-01 00:00:00

abstract：BACKGROUND:Whether exposure to a single general anaesthetic (GA) in early childhood causes long-term neurodevelopmental problems remains unclear. METHODS:PubMed/MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Library were searched from inception to October 2019. Studies evaluating neurodevelopmental outcomes...

journal_title：British journal of anaesthesia

authors： Ing C,Jackson WM,Zaccariello MJ,Goldberg TE,McCann ME,Grobler A,Davidson A,Sun L,Li G,Warner DO

更新日期：2021-02-01 00:00:00

abstract：:The serum vasopressin (S-AVP) concentration, serum sodium concentration and osmolality, central venous pressure and fluid balance were measured during 10-min periods in 32 patients undergoing transurethral resection of the prostate. Concentration of S-AVP was unaffected by uncomplicated resection; irrigant absorption ...

journal_title：British journal of anaesthesia

authors： Hahn RG,Rundgren M

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Fibrinolysis contributes to coagulopathy after major trauma and surgery. We hypothesized that progressive haemodilution is responsible, at least in part, for increased fibrinolytic tendency of blood clot. METHODS:The study was performed in two parts. First, whole blood (WB) samples collected from six health...

journal_title：British journal of anaesthesia

authors： Bolliger D,Szlam F,Levy JH,Molinaro RJ,Tanaka KA

更新日期：2010-03-01 00:00:00

abstract：:Percutaneous dilatational tracheostomy (PDT) is associated with a number of life-threatening complications. We present a case of massive and fatal arterial haemorrhage that occurred in the intensive care unit during an elective PDT on an 86-year-old woman following earlier evacuation of a traumatic subdural haematoma....

journal_title：British journal of anaesthesia

authors： Shlugman D,Satya-Krishna R,Loh L

更新日期：2003-04-01 00:00:00

abstract：:A double-blind trial was undertaken to compare the effects of trimeprazine tartrate (2 mg kg-1 or 4 mg kg-1) plus atropine 0.03 mg kg-1 for oral premedication of 192 children undergoing tonsillectomy. Demeanour before operation, side-effects after operation, recovery times and fluid balance were studied. Behaviour in ...

journal_title：British journal of anaesthesia

authors： Bramwell RG,Manford ML

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Supraglottic airways (SGAs) have an established role in airway management of difficult airways in both adults and children. However, there are limited data regarding the use of SGAs for primary airway management in children. The aim of this study is to assess the success rates and adverse events related to t...

journal_title：British journal of anaesthesia

authors： Jagannathan N,Sequera-Ramos L,Sohn L,Wallis B,Shertzer A,Schaldenbrand K

更新日期：2014-04-01 00:00:00

abstract：:Frailty is a syndrome of cumulative decline across multiple physiological systems, which predisposes vulnerable adults to adverse events. Assessing vulnerable patients can potentially lead to interventions that improve surgical outcomes. Anaesthesiologists who care for older patients can identify frailty to improve pr...

journal_title：British journal of anaesthesia

authors： Bentov I,Kaplan SJ,Pham TN,Reed MJ

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:This study compared the efficacy of topical anaesthesia with levobupivacaine 0.75% vs lidocaine 2% during cataract surgery by phacoemulsification. METHODS:A prospective, randomized, double-blind study comparing two agents for topical anaesthesia in cataract surgery. Two hundred and forty-six consecutive pat...

journal_title：British journal of anaesthesia

authors： Fernández SA,Dios E,Diz JC

更新日期：2009-02-01 00:00:00

abstract：:Riluzole modulates several transmitter systems which may be involved in nociception. Antinociceptive effects have been shown in animal studies, but there are no human data. Therefore, we have examined the acute analgesic effect of riluzole in a human model of inflammatory pain induced by a thermal injury on the distal...

journal_title：British journal of anaesthesia

authors： Hammer NA,Lillesø J,Pedersen JL,Kehlet H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Robotic-assisted laparoscopic radical prostatectomy (RALRP) is gaining popularity as a less traumatic and minimally invasive alternative to open radical retropubic prostatectomy (RRP). The aim of this study was to evaluate the incidence and grade of venous gas embolism (VGE) during RALRP compared with those ...

journal_title：British journal of anaesthesia

authors： Hong JY,Kim JY,Choi YD,Rha KH,Yoon SJ,Kil HK

更新日期：2010-12-01 00:00:00

abstract：:We have compared the effects of dexmedetomidine and propofol on endocrine, metabolic, inflammatory and cardiovascular responses in patients in the intensive care unit (ICU) after major surgery. Twenty patients who were expected to require 8 h of post-operative sedation and ventilation were allocated randomly to receiv...

journal_title：British journal of anaesthesia

authors： Venn RM,Bryant A,Hall GM,Grounds RM

更新日期：2001-05-01 00:00:00

abstract：:Thirty hypertensive patients scheduled for cholecystectomy or hernia repair under general anaesthesia with thiopentone-fentanyl-nitrous oxide-pancuronium were divided into two groups of 15. One group received metoprolol tablets 200 mg in a slow release form, once daily for at least 2 weeks including the morning of sur...

journal_title：British journal of anaesthesia

authors： Magnusson J,Thulin T,Werner O,Järhult J,Thomson D

更新日期：1986-03-01 00:00:00

abstract：:Atropine and glycopyrrolate were compared in a mixture with neostigmine for reversal of neuromuscular blockade in patients undergoing open heart surgery. In patients not receiving beta-blocking drugs, glycopyrrolate was shown to possess advantages over atropine in terms of a lower initial increase in heart rate, bette...

journal_title：British journal of anaesthesia

authors： Salem MG,Richardson JC,Meadows GA,Lamplugh G,Lai KM

更新日期：1985-02-01 00:00:00

abstract：:We report the extradural administration of low-dose morphine in 10 ml of 10% dextrose (2-3 mg) to 98 adult patients with various types of acute and chronic pain. Extradural morphine injections were given either via a Tuohy needle (single or repeat injection) or via an extradural catheter. Pain relief was evaluated by ...

journal_title：British journal of anaesthesia

authors： Magora F,Olshwang D,Eimerl D,Shorr J,Katzenelson R,Cotev S,Davidson JT

更新日期：1980-03-01 00:00:00

abstract：:Volatile anaesthetics have been shown to have direct relaxant effects on airway smooth muscle. We have examined the effects of 0.9, 1.9, and 2.8 dog MAC of desflurane and halothane on isolated proximal and distal canine airways precontracted with acetylcholine. The proximal and distal airway smooth muscle relaxed with...

journal_title：British journal of anaesthesia

authors： Mazzeo AJ,Cheng EY,Bosnjak ZJ,Coon RL,Kampine JP

更新日期：1996-06-01 00:00:00

abstract：:Recent research has shown that high-frequency, gamma-band electroencephalographic (EEG) oscillations (40-60 Hz) may be an important marker of the conscious state. We compared the ability of the bispectral index (BIS) to distinguish the awake and anaesthetized states during the induction of general anaesthesia with: (i...

journal_title：British journal of anaesthesia

authors： Sleigh JW,Steyn-Ross DA,Steyn-Ross ML,Williams ML,Smith P

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Mechanosensory thalamocortical relay neurones (TCNs) receive glutamatergic excitatory input and are subjected to gamma-aminobutyric acid (GABA)Aergic inhibitory input. This study assessed the effects of an increase in concentration of isoflurane on thalamic excitatory and inhibitory mechanisms. METHODS:TCNs...

journal_title：British journal of anaesthesia

authors： Detsch O,Kochs E,Siemers M,Bromm B,Vahle-Hinz C

更新日期：2002-08-01 00:00:00

abstract：:A blind comparison was made of butorphanol 2 mg with morphine 10 mg i.m. as the sole premedication in four groups, each of 10 women, undergoing total abdominal hysterectomy. On both subjective and objective grounds, butorphanol was as effective as morphine with the advantage of fewer unwanted side-effects, although on...

journal_title：British journal of anaesthesia

authors： Laffey DA,Kay NH

更新日期：1984-04-01 00:00:00

abstract：:Arterial PO2 (PaO2) has been related to inspired oxygen concentration (FIO2 range 0.21-0.60) in 20 patients, breathing spontaneously, while recovering from a range of conditions treated in an intensive therapy unit. There was a highly significant linear trend (P < 0.001) for the mean venous admixture ("virtual shunt")...

journal_title：British journal of anaesthesia

authors： Petros AJ,Doré CJ,Nunn JF

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Beta-adrenergic agonists enhance behavioural and electroencephalographic arousal reactions. We explored whether adding esmolol, a short-acting beta(1)-adrenoceptor antagonist, to propofol anaesthesia modified the bispectral index (BIS) during induction of anaesthesia and orotracheal intubation. METHODS:Fift...

journal_title：British journal of anaesthesia

authors： Menigaux C,Guignard B,Adam F,Sessler DI,Joly V,Chauvin M

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:The analgesic efficacy of continuous transversus abdominis plane (TAP) blocks in comparison with that of single-injection TAP blocks is not clear. This randomized, triple-blind, placebo-controlled trial investigated the benefits of adding continuous TAP blocks to single-injection TAP blocks after a laparotom...

journal_title：British journal of anaesthesia

authors： Yoshida T,Furutani K,Watanabe Y,Ohashi N,Baba H

更新日期：2016-12-01 00:00:00

abstract：:We have measured in a double-blind study the changes in intraocular pressure (IOP) in 40 consecutive patients (pretreated with fentanyl or alfentanil) who received suxamethonium and tracheal intubation. Although IOP increased significantly following administration of suxamethonium, mean IOP in both groups remained sig...

journal_title：British journal of anaesthesia

authors： Sweeney J,Underhill S,Dowd T,Mostafa SM

更新日期：1989-12-01 00:00:00

abstract：:We have studied post-tetanic count (PTC) and single twitch height at the onset of reflex movement to carinal stimulation after administration of vecuronium with five different types of anaesthesia. Seventy-five adult patients were allocated randomly to five groups of 15 patients each, to receive one of the following a...

journal_title：British journal of anaesthesia

authors： Saitoh Y,Kaneda K,Toyooka H,Amaha K

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are unproven in patients ventilated with low tidal volumes. METHODS:Fourteen patients were studied immediately after coronary a...

journal_title：British journal of anaesthesia

authors： Rex S,Brose S,Metzelder S,Hüneke R,Schälte G,Autschbach R,Rossaint R,Buhre W

更新日期：2004-12-01 00:00:00

abstract：:A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia, peritoneal dialysis using a cold dialysate, is described. Experimental observations in a young man on a regular peritoneal dialysis regime showed that significant heat extraction can be obtained when either a cool (20 degrees C) or...

journal_title：British journal of anaesthesia

authors： Gjessing J,Barsa J,Tomlin PJ

更新日期：1976-05-01 00:00:00