Electromagnetic millimeter wave induced hypoalgesia: frequency dependence and involvement of endogenous opioids.

Abstract:

:Millimeter wave treatment (MMWT) is based on the systemic biological effects that develop following local skin exposure to low power electromagnetic waves in the millimeter range. In the present set of experiments, the hypoalgesic effect of this treatment was analyzed in mice. The murine nose area was exposed to MMW of "therapeutic" frequencies: 42.25, 53.57, and 61.22 GHz. MMWT-induced hypoalgesia was shown to be frequency dependent in two experimental models: (1) the cold water tail-flick test (chronic non-neuropathic pain), and (2) the wire surface test (chronic neuropathic pain following unilateral constriction injury to the sciatic nerve). Maximum hypoalgesic effect was obtained when the frequency was 61.22 GHz. Other exposure parameters were: incident power density = 13.3 mW/cm(2), duration of each exposure = 15 min. Involvement of delta and kappa endogenous opioids in the MMWT-induced hypoalgesia was demonstrated using selective blockers of delta- and kappa-opioid receptors and the direct ELISA measurement of endogenous opioids in CNS tissue. Possible mechanisms of the effect and the perspectives of the clinical application of MMWT are discussed.

journal_name

Bioelectromagnetics

journal_title

Bioelectromagnetics

authors

Radzievsky AA,Gordiienko OV,Alekseev S,Szabo I,Cowan A,Ziskin MC

doi

10.1002/bem.20389

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

284-95

issue

4

eissn

0197-8462

issn

1521-186X

journal_volume

29

pub_type

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