Abstract:
:Millimeter wave treatment (MMWT) is based on the systemic biological effects that develop following local skin exposure to low power electromagnetic waves in the millimeter range. In the present set of experiments, the hypoalgesic effect of this treatment was analyzed in mice. The murine nose area was exposed to MMW of "therapeutic" frequencies: 42.25, 53.57, and 61.22 GHz. MMWT-induced hypoalgesia was shown to be frequency dependent in two experimental models: (1) the cold water tail-flick test (chronic non-neuropathic pain), and (2) the wire surface test (chronic neuropathic pain following unilateral constriction injury to the sciatic nerve). Maximum hypoalgesic effect was obtained when the frequency was 61.22 GHz. Other exposure parameters were: incident power density = 13.3 mW/cm(2), duration of each exposure = 15 min. Involvement of delta and kappa endogenous opioids in the MMWT-induced hypoalgesia was demonstrated using selective blockers of delta- and kappa-opioid receptors and the direct ELISA measurement of endogenous opioids in CNS tissue. Possible mechanisms of the effect and the perspectives of the clinical application of MMWT are discussed.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Radzievsky AA,Gordiienko OV,Alekseev S,Szabo I,Cowan A,Ziskin MCdoi
10.1002/bem.20389subject
Has Abstractpub_date
2008-05-01 00:00:00pages
284-95issue
4eissn
0197-8462issn
1521-186Xjournal_volume
29pub_type
杂志文章abstract::It has been suggested that exposure to electromagnetic fields may be a risk factor for cardiovascular disease in humans. Low density lipoprotein (LDL) modifications such as peroxidation and aggregation have been implicated in the pathogenesis of atherosclerosis. The present study investigated the effects of weak (0.12...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250110306
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250160409
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abstract::Childhood cancer has been modestly associated with wire codes, an exposure surrogate for power frequency magnetic fields, but less consistently with measured fields. We analyzed data on the population distribution of wire codes and their relationship with several measured magnetic field metrics. In a given geographic ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
abstract::The constant exposure of modern society to extremely low frequency magnetic fields (ELF-MF) has raised considerable concerns about the potential risks to male reproduction. However, the epidemiological and experimental data remain contradictory and inconclusive. In the present study, we investigated the effects of 50 ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250050406
更新日期:1984-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20458
更新日期:2009-04-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20431
更新日期:2008-10-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250030108
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20073
更新日期:2005-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250110206
更新日期:1990-01-01 00:00:00
abstract::Chemical and bacterial synthesis of a thermochemiluminescent polymer known as diazoluminomelanin (DALM) has been previously reported. This paper focuses on the intracellular synthesis of aminomelanin (AM) in mammalian cell lines and subsequent DALM synthesis from this core molecule. B16 melanoma cells, HL-60 myeloid l...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250150406
更新日期:1994-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250160505
更新日期:1995-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20569
更新日期:2010-05-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The aim of the present study was to determine millimeter wave (MMW) absorption by blood vessels traversing the subcutaneous fat layer of murine skin. Most calculations were performed using the finite-difference time-domain (FDTD) technique. We used two types of models: (1) a rectangular block of multilayer tissue with...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20658
更新日期:2011-09-01 00:00:00
abstract::In studies investigating adverse reproductive outcomes associated with video display terminal (VDT) usage, amounts of time spent in front of a VDT or magnetic field (MF) levels in front of the VDT are used as surrogate measures of subject's MF exposure. However, the relevance of such surrogates to actual exposures has...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
abstract::Occupational exposure to the high static magnetic fields (SMFs) during magnetic resonance imaging (MRI) examinations raises concerns of adverse health effects. In this study, personal exposure monitoring of the magnetic fields during routine examinations in two 3 T MRI systems was carried out. A three-axis Hall magnet...
journal_title:Bioelectromagnetics
pub_type: 杂志文章,多中心研究
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21977
更新日期:2016-07-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20203
更新日期:2006-09-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 信件
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更新日期:2014-07-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250080307
更新日期:1987-01-01 00:00:00
abstract::Extremely-low-frequency (ELF) and very-low-frequency (VLF) magnetic fields as emitted by monochrome and multichrome video display units (VDUs) were measured for their frequency domains. The rms magnetic-flux densities (MFDs) were measured as a function of distance from all six sides of VDUs of four types. The MFDs at ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250120106
更新日期:1991-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250020105
更新日期:1981-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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