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Hypoxia regulates the expression of fatty acid-binding proteins in primary term human trophoblasts.

Abstract：

OBJECTIVE:Fatty acids (FAs) are essential for fetal development. Cellular FA uptake is modulated by fatty acid-binding proteins (FABPs). We hypothesized that hypoxia regulates the expression of FABPs in human trophoblasts. STUDY DESIGN:Primary term human trophoblasts were cultured for 72 hours in either standard (O2 = 20%) or hypoxic (O2 < 1%) conditions. FABP expression was interrogated using polymerase chain reaction and Western immunoblotting. Trophoblast lipid droplets were examined using dipyrromethene boron difluoride 493/503 staining. RESULTS:We detected the expression of FABP1, -3, -4, -5, and pm but not FABP2 or FABP6-9 subtypes in trophoblasts. Exposure to hypoxia markedly increased lipid droplet accumulation in trophoblasts. Consistent with this observation, hypoxia enhanced the expression of FABP1, -3, and -4. Lastly, agonists of peroxisome proliferator-activated receptor-gamma enhanced the expression of FABP1 and -4 in trophoblasts. CONCLUSION:Hypoxia enhances the expression of FABP1, -3, and -4 in term human trophoblasts, suggesting that FABPs support fat accumulation in the hypoxic placenta.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Biron-Shental T,Schaiff WT,Ratajczak CK,Bildirici I,Nelson DM,Sadovsky Y

doi

10.1016/j.ajog.2007.03.066

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

516.e1-6

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(07)00432-2

journal_volume

197

pub_type

杂志文章

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