Abstract:
BACKGROUND:Ropivacaine is a long-acting local anesthetic with low cardiac toxicity that induces vasoconstriction in vitro and in vivo. Vascular smooth muscle tone is regulated by changes in both intracellular Ca(2+) concentration ([Ca(2+)](i)) and myofilament Ca(2+) sensitivity. Therefore, the aim of this study was to examine the mechanism underlying the increase in [Ca(2+)](i) in ropivacaine-induced vascular contraction. METHODS:Ropivacaine-induced contractile responses and changes in [Ca(2+)](i) were examined using an isometric force transducer and a fluorometer, respectively. RESULTS:Ropivacaine induced a biphasic, concentration-dependent change in [Ca(2+)](i) and contractile response in rat aortic smooth muscles: an increase in [Ca(2+)](i) occurred at lower ropivacaine concentrations (3 x 10(-5) to 3 x 10(-4) M) and a decrease was observed at higher concentrations (10(-3) to 3 x 10(-3) M). Contraction and the [Ca(2+)](i) increase induced by ropivacaine were attenuated significantly by a voltage-dependent Ca(2+) channel antagonist, an inositol 1,4,5-triphosphate receptor antagonist and Ca(2+)-free solution (P < 0.01, n = 6). CONCLUSION:Ropivacaine-induced contraction of rat aortic smooth muscle is, in part, regulated by Ca(2+) influx from the extracellular space and Ca(2+) release from the sarcoplasmic reticulum.
journal_name
Acta Anaesthesiol Scandjournal_title
Acta anaesthesiologica Scandinavicaauthors
Tokinaga Y,Ogawa K,Yu J,Kuriyama T,Minonishi T,Hatano Ydoi
10.1111/j.1399-6576.2007.01390.xsubject
Has Abstractpub_date
2007-10-01 00:00:00pages
1155-60issue
9eissn
0001-5172issn
1399-6576pii
AAS1390journal_volume
51pub_type
杂志文章abstract::The aim of this study was to compare propofol produced EEG burst suppression with isoflurane produced burst suppression in rabbits and to see whether rabbits can serve as models in studying the effects of different anaesthetics on human EEG. We recorded EEG of eight rabbits anaesthetised with isoflurane and propofol. ...
journal_title:Acta anaesthesiologica Scandinavica
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doi:10.1111/j.1399-6576.1995.tb04176.x
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journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1399-6576.1984.tb02053.x
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journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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更新日期:1975-01-01 00:00:00
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journal_title:Acta anaesthesiologica Scandinavica
pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00