Abstract:
:We employed physiogenomic analyses to investigate the relationship between myalgia and selected polymorphisms in serotonergic genes, based on their involvement with pain perception and transduction of nociceptive stimuli. We screened 195 hypercholesterolemic, statin-treated patients, all of whom received either atorvastatin, simvastatin, or pravastatin. Patients were classified as having no myalgia, probable myalgia, or definite myalgia, and assigned a myalgia score of 0, 0.5, or 1, respectively. Fourteen single nucleotide polymorphisms (SNPs) were selected from candidates within the 5-HT receptor gene families [5a-hydroxytryptamine receptor genes (HTR) 1D, 2A, 2C, 3A, 3B, 5A, 6, 7] and the serotonin transporter gene (SLC6A4). SNPs in the HTR3B and HTR7 genes, rs2276307 and rs1935349, respectively, were significantly associated with the myalgia score. Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Ruaño G,Thompson PD,Windemuth A,Seip RL,Dande A,Sorokin A,Kocherla M,Smith A,Holford TR,Wu AHdoi
10.1002/mus.20871subject
Has Abstractpub_date
2007-09-01 00:00:00pages
329-35issue
3eissn
0148-639Xissn
1097-4598journal_volume
36pub_type
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