Peripheral nervous system involvement in chronic spinal cord injury.


INTRODUCTION:Upper motor neuron disorders are believed to leave the peripheral nervous system (PNS) intact. In this study we examined whether there is evidence of PNS involvement in spinal cord injury (SCI). METHODS:Twelve subjects with chronic low cervical or thoracic SCI were included prospectively. Needle electromyography was done in 10 different muscles in each subject bilaterally. Nerve conduction studies (NCS) were conducted in the fibular, tibial, and femoral motor and fibular and sural sensory nerves. RESULTS:Half the subjects had widespread abnormal spontaneous activity (SA), and the amount of SA correlated inversely with reflex activity and nerve length. Fibular nerve entrapment across the knee was seen in 6 subjects, and sciatic nerve entrapment was seen in 1. Apart from entrapment neuropathies, NCS changes were found predominantly in motor nerves. CONCLUSION:The presence of widespread electrophysiologic changes outside entrapment sites indicates that SCI has a significant impact on the entire PNS, affecting the motor part predominantly.


Muscle Nerve


Muscle & nerve


Tankisi H,Pugdahl K,Rasmussen MM,Clemmensen D,Rawashdeh YF,Christensen P,Krogh K,Fuglsang-Frederiksen A




Has Abstract


2015-12-01 00:00:00












  • Clinical and molecular aspects of the myotonic dystrophies: a review.

    abstract::Type 1 myotonic dystrophy or DM1 (Steinert's disease), which is the commonest muscular dystrophy in adults, has intrigued physicians for over a century. Unusual features, compared with other dystrophies, include myotonia, anticipation, and involvement of other organs, notably the brain, eyes, smooth muscle, cardiac co...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Machuca-Tzili L,Brook D,Hilton-Jones D

    更新日期:2005-07-01 00:00:00

  • Optimal location for eliciting the tibial H-reflex and motor response.

    abstract:INTRODUCTION:Although there are numerous protocols to adjust the amplitude of the Hoffmann reflex (H-reflex) relative to the size of the direct motor response (M-response), the optimal stimulating location has not been described. We sought to determine the optimal positioning of the stimulating cathode when evoking the...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Özyurt MG,Shabsog M,Dursun M,Türker KS

    更新日期:2018-12-01 00:00:00

  • A syndrome of concurrent central and peripheral nervous system involvement due to Epstein-Barr virus infection.

    abstract::Epstein-Barr virus infection can affect both the central and peripheral nervous system. In some patients this occurs concurrently. Two patients are presented with encephalopathy and acute quadriparesis with diminished reflexes. Positive serology for Epstein-Barr virus was found in both patients. Both patients had a ce...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Morgenlander JC

    更新日期:1996-08-01 00:00:00

  • Autophagy markers LC3 and p62 accumulate in immune-mediated necrotizing myopathy.

    abstract:INTRODUCTION:The molecular mechanism of immune-mediated necrotizing myopathy (IMNM) remains unknown. Autophagy impairment, described in autoimmune diseases, is a key process in myofiber protein degradation flux and muscle integrity and has not been studied in IMNM. METHODS:Muscle biopsies from patients with IMNM (n = ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Girolamo F,Lia A,Annese T,Giannini M,Amati A,D'Abbicco D,Tampoia M,Virgintino D,Ribatti D,Serlenga L,Iannone F,Trojano M

    更新日期:2019-09-01 00:00:00

  • Electrical muscle stimulation after immediate nerve repair reduces muscle atrophy without affecting reinnervation.

    abstract:INTRODUCTION:Electrical stimulation of denervated muscle has been shown to minimize atrophy and fibrosis and increase force in animal and human models. However, electrical stimulation after nerve repair is controversial due to questions of efficacy. METHODS:Using a rat model, we investigated the efficacy of short-term...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Willand MP,Holmes M,Bain JR,Fahnestock M,De Bruin H

    更新日期:2013-08-01 00:00:00

  • Sparing of the flexor carpi ulnaris in ulnar neuropathy at the elbow.

    abstract::A common misconception attributes sparing of the flexor carpi ulnaris (FCU) in ulnar neuropathy at the elbow (UNE) to its innervating branch arising "at or above the elbow." We examined the relationship of FCU branches to the medial epicondyle (ME) and humeroulnar aponeurotic arcade (HUA) in 30 cadaver elbows. In only...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Campbell WW,Pridgeon RM,Riaz G,Astruc J,Leahy M,Crostic EG

    更新日期:1989-12-01 00:00:00

  • Fluctuations in motor output during steady contractions are weakly related across contraction types and between hands.

    abstract::The presence of differences in motor unit activity across contraction types and between hands suggests that the magnitude of fluctuations in motor output is only weakly related when these conditions are compared. Twenty right-handed young (24.1 +/- 5.3 years) and old (72.5 +/- 4.9 years) adults performed three levels ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Shinohara M,Keenan KG,Enoka RM

    更新日期:2005-06-01 00:00:00

  • Frontal plane ankle proprioceptive thresholds and unipedal balance.

    abstract::Reliable unipedal balance is fundamental to safe ambulation. Accordingly, older persons with peripheral neuropathy (PN), who are at increased risk for falls, demonstrate impaired unipedal balance. To explore the relationship between afferent function and unipedal balance, frontal plane proprioceptive thresholds at the...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Son J,Ashton-Miller JA,Richardson JK

    更新日期:2009-02-01 00:00:00

  • Modification of the peripheral nerve disturbance in ciguatera poisoning in rats with lidocaine.

    abstract::Electrophysiological studies were performed on the ventral tail nerve of adult rats following intraperitoneal injection of a crude extract of ciguatoxin from known toxic fish flesh. Ciguatoxin induced significant slowing of both mixed and motor nerve conduction velocities and also significant reductions in both motor ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Cameron J,Flowers AE,Capra MF

    更新日期:1993-07-01 00:00:00

  • Action potential shape of rabbit masseter motor units and jaw angle.

    abstract::Action potentials of rabbit masseter motor units (n = 42) were registered at different jaw angles to examine whether the shape of the action potential is related to length of muscle fibers in motor units and depends on the intramuscular location of the motor unit. Twitches were elicited by stimulating motoneurons in t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Turkawski SJ,van Eijden TM

    更新日期:2001-11-01 00:00:00

  • Inaccurate projection of rat soleus motoneurons: a comparison of nerve repair techniques.

    abstract::The objectives of this study were 1) to determine the degree to which soleus motoneurons find their appropriate target following crush and transection injuries to the sciatic nerve, and 2) to determine whether repair of a transected nerve with a silicone tube leads to greater specificity of reinnervation and recovery ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Bodine-Fowler SC,Meyer RS,Moskovitz A,Abrams R,Botte MJ

    更新日期:1997-01-01 00:00:00

  • Neuroimaging of classic neuralgic amyotrophy.

    abstract:INTRODUCTION:Neuralgic amyotrophy (NA) often imposes diagnostic problems. Recently, MRI and high-resolution ultrasound (HRUS) have proven useful in diagnosing peripheral nerve disorders. METHODS:We performed a chart and imaging review of patients who were examined using neuroimaging and who were referred because of cl...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Lieba-Samal D,Jengojan S,Kasprian G,Wöber C,Bodner G

    更新日期:2016-12-01 00:00:00

  • Association between wrist ratio and carpal tunnel syndrome: Effect modification by body mass index.

    abstract:INTRODUCTION:Previous studies have reported higher wrist ratios (WR) related to carpal tunnel syndrome (CTS) but have not assessed effect modification by obesity and may have inadequately controlled for confounders. METHODS:Baseline data of a multicenter prospective cohort study were analyzed. CTS was defined by nerve...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,多中心研究


    authors: Thiese MS,Merryweather A,Koric A,Ott U,Wood EM,Kapellusch J,Foster J,Garg A,Deckow-Schaefer G,Tomich S,Kendall R,Drury DL,Wertsch J,Hegmann KT,Wistah Study Team.

    更新日期:2017-12-01 00:00:00

  • Activity of Krebs cycle enzymes in mdx mice.

    abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we ev...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Comim CM,Hoepers A,Ventura L,Freiberger V,Dominguini D,Mina F,Mendonça BP,Scaini G,Vainzof M,Streck EL,Quevedo J

    更新日期:2016-01-01 00:00:00

  • Physical function and mobility in children with congenital myotonic dystrophy.

    abstract:INTRODUCTION:Congenital myotonic dystrophy (CDM) occurs when symptoms of myotonic dystrophy present at birth. In this study we evaluated the relationship between physical function, muscle mass, and age to provide an assessment of the disease and help prepare for therapeutic trials. METHODS:CDM participants performed t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Pucillo EM,Dibella DL,Hung M,Bounsanga J,Crockett B,Dixon M,Butterfield RJ,Campbell C,Johnson NE

    更新日期:2017-08-01 00:00:00

  • Compound muscle action potential duration in critical illness neuromyopathy.

    abstract:INTRODUCTION:We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. METHODS:Fifty-eight patients with CINM who had been seen over a 17-year period were r...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kramer CL,Boon AJ,Harper CM,Goodman BP

    更新日期:2018-03-01 00:00:00

  • Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes.

    abstract::Skeletal muscle cells are hypertrophied by mechanical stresses, but the underlying molecular mechanisms are not fully understood. Two signaling pathways, phosphatidylinositol 3-kinase (PI3K)/Akt to target of rapamycin (TOR) and extracellular signal-regulated kinase kinase (MEK) to extracellular signal-regulated kinase...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Sasai N,Agata N,Inoue-Miyazu M,Kawakami K,Kobayashi K,Sokabe M,Hayakawa K

    更新日期:2010-01-01 00:00:00

  • Myonuclear domains in muscle adaptation and disease.

    abstract::Adult skeletal muscle fibers are among the few cell types that are truly multinucleated. Recently, evidence has accumulated supporting a role for the modulation of myonuclear number during muscle remodeling in response to injury, adaptation, and disease. These studies have demonstrated that muscle hypertrophy is assoc...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Allen DL,Roy RR,Edgerton VR

    更新日期:1999-10-01 00:00:00

  • Skeletal muscle response to tenotomy.

    abstract::Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central c...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Jamali AA,Afshar P,Abrams RA,Lieber RL

    更新日期:2000-06-01 00:00:00

  • Endocannabinoids and related lipids in serum from patients with amyotrophic lateral sclerosis.

    abstract:BACKGROUND:The goals of this study were to determine whether serum concentrations of endocannabinoids (eCB) and related lipids predict disease status in patients with amyotrophic lateral sclerosis (ALS) relative to healthy controls, and whether concentrations correlate with disease duration and severity. METHODS:Serum...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Carter GT,McLaughlin RJ,Cuttler C,Sauber GJ,Weeks DL,Hillard CJ,Weiss MD

    更新日期:2021-01-01 00:00:00

  • Heterogeneity of muscle sizes in the lower limbs of children with cerebral palsy.

    abstract:INTRODUCTION:Cerebral palsy (CP) is associated with reduced muscle volumes, but previous studies have reported deficits in only a small number of muscles. The extent of volume deficits across lower limb muscles is not known. This study presents an imaging-based assessment of muscle volume and length deficits in 35 lowe...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Handsfield GG,Meyer CH,Abel MF,Blemker SS

    更新日期:2016-06-01 00:00:00

  • Clinical, physiological, and histological features in a kindred with the T3271C melas mutation.

    abstract::The majority of patients with MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) have an A-->G mutation at nucleotide 3243 in mitochondrial transfer (t)RNA. To date there have only been 10 reported cases of MELAS syndrome in patients with a T-->C mutation at position 3271...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Tarnopolsky MA,Maguire J,Myint T,Applegarth D,Robinson BH

    更新日期:1998-01-01 00:00:00

  • Slower conduction velocity and motor unit discharge frequency are associated with muscle fatigue during isometric exercise in type 1 diabetes mellitus.

    abstract::Type 1 diabetes mellitus (T1DM) is associated with a peripheral neuropathy that reduces nerve conduction velocity. This may impair high motor-unit discharge frequencies (MUDF), decrease muscle activation, and curtail the ability to sustain repetitive contractile tasks. We examined (1) whether MUDF, the contractile pro...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章


    authors: Almeida S,Riddell MC,Cafarelli E

    更新日期:2008-02-01 00:00:00

  • Muscle activation of the quadriceps and hamstrings during incremental running.

    abstract:INTRODUCTION:The aim of this study was to determine the patterns of responses for the electromyographic (EMG) amplitude vs. oxygen uptake ( V̇O2 ) relationships from muscles of the quadriceps femoris and hamstrings during incremental treadmill running. METHODS:Twelve men volunteered to perform an incremental test to e...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Camic CL,Kovacs AJ,Enquist EA,McLain TA,Hill EC

    更新日期:2015-12-01 00:00:00

  • Polysaccharide storage myopathy.

    abstract::In a woman with a slowly progressive adult onset proximal myopathy, muscle biopsy showed storage of PAS positive material in type 1 fibers. This material consisted of a branched chain polysaccharide associated with a mucoprotein. No abnormality of glycogen-pathway enzymes was detected. This suggested that this polysac...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Thompson AJ,Swash M,Cox EL,Ingram DA,Gray A,Schwartz MS

    更新日期:1988-04-01 00:00:00

  • Reduced oxidative muscle metabolism in chronic fatigue syndrome.

    abstract::The purpose of this study was to determine if chronic fatigue syndrome (CSF) is characterized by abnormalities in oxidative muscle metabolism. Patients with CFS according to Centers for Disease Control (CDC) criteria (n = 22) were compared to normal sedentary subjects (n = 15). CFS patients were also tested before and...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: McCully KK,Natelson BH,Iotti S,Sisto S,Leigh JS Jr

    更新日期:1996-05-01 00:00:00

  • Changes in muscle force-length properties affect the early rise of force in vivo.

    abstract::Changes in contractile rate of force development (RFD), measured within a short time interval from contraction initiation, were measured after a period of strength training that led to increases in muscle fascicle length but no measurable change in neuromuscular activity. The relationship between training-induced shif...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Blazevich AJ,Cannavan D,Horne S,Coleman DR,Aagaard P

    更新日期:2009-04-01 00:00:00

  • L1 radiculopathy mimicking meralgia paresthetica: a case report.

    abstract::L1 radiculopathy is very rare and difficult to diagnose with needle electromyography. A patient presented with pain and hypesthesia on the anterolateral aspect of the left thigh. Nerve conduction studies and needle electromyography were normal, except for the quadratus lumborum and iliopsoas muscles, which showed abno...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Yang SN,Kim DH

    更新日期:2010-04-01 00:00:00

  • Passive trunk loading influences muscle activation during dynamic activity.

    abstract:INTRODUCTION:Repetitive loading of the low back tissues induces tension relaxation with a corresponding variation in the myoelectric response of the neuromuscular system, which may influence low back health. The purpose of this study was to observe trunk muscle activities before and after a passive cyclic trunk flexion...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Olson MW

    更新日期:2011-11-01 00:00:00

  • Activity of 2'3'-cyclic-nucleotide 3'-phosphodiesterase and content of PO protein in the peripheral nervous system of the dystrophic mouse and chicken.

    abstract::To investigate whether various myelin markers could detect pathological changes in myelination, the activity of 2'-3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and the level of PO protein were compared in the peripheral nervous system (PNS) of the dystrophic mouse and chicken and their phenotypically normal sibling...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Lewis LN,Mezei C

    更新日期:1985-02-01 00:00:00