Peripheral nervous system involvement in chronic spinal cord injury.


INTRODUCTION:Upper motor neuron disorders are believed to leave the peripheral nervous system (PNS) intact. In this study we examined whether there is evidence of PNS involvement in spinal cord injury (SCI). METHODS:Twelve subjects with chronic low cervical or thoracic SCI were included prospectively. Needle electromyography was done in 10 different muscles in each subject bilaterally. Nerve conduction studies (NCS) were conducted in the fibular, tibial, and femoral motor and fibular and sural sensory nerves. RESULTS:Half the subjects had widespread abnormal spontaneous activity (SA), and the amount of SA correlated inversely with reflex activity and nerve length. Fibular nerve entrapment across the knee was seen in 6 subjects, and sciatic nerve entrapment was seen in 1. Apart from entrapment neuropathies, NCS changes were found predominantly in motor nerves. CONCLUSION:The presence of widespread electrophysiologic changes outside entrapment sites indicates that SCI has a significant impact on the entire PNS, affecting the motor part predominantly.


Muscle Nerve


Muscle & nerve


Tankisi H,Pugdahl K,Rasmussen MM,Clemmensen D,Rawashdeh YF,Christensen P,Krogh K,Fuglsang-Frederiksen A




Has Abstract


2015-12-01 00:00:00












  • Ultrasound elastography for the evaluation of peripheral nerves: A systematic review.

    abstract::Peripheral nerve disorders are commonly encountered in clinical practice. Electrodiagnostic studies remain the cornerstone of the evaluation of nerve disorders. More recently, ultrasound has played an increasing complementary role in the neuromuscular clinic. Ultrasound elastography is a technique that measures the el...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Wee TC,Simon NG

    更新日期:2019-11-01 00:00:00

  • Do A-waves help predict intravenous immunoglobulin response in multifocal motor neuropathy without block?

    abstract:INTRODUCTION:Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)? METHODS:We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Lange DJ,Nijjar R,Voustianiouk A,Seidel G,Panchal J,Wang AK

    更新日期:2011-04-01 00:00:00

  • EMG changes in respiratory and skeletal muscles during isometric contraction under normoxic, hypoxemic, or ischemic conditions.

    abstract::The consequences of general hypoxemia (PaO2 = 51 mmHg) on two muscle groups (adductor pollicis and diaphragm) sustaining 80% maximal isometric voluntary contraction were studied in healthy individuals. For adductor pollicis, contractions were also executed after 10-s or 3-min rest ischemia. Compared to control, i.e., ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Badier M,Guillot C,Lagier-Tessonnier F,Jammes Y

    更新日期:1994-05-01 00:00:00

  • Skeletal muscle response to tenotomy.

    abstract::Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central c...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Jamali AA,Afshar P,Abrams RA,Lieber RL

    更新日期:2000-06-01 00:00:00

  • Relationship between electrical and vibratory output of muscle during voluntary contraction and fatigue.

    abstract::Measurements were done on the biceps muscles of 6 healthy volunteers to record simultaneously the surface electromyogram (EMG) and vibromyogram (VMG) by means of a piezoelectric device (accelerometer). The VMG is generated by mechanical waves due to the contraction mechanism and often measured as sound. The frequency ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Zwarts MJ,Keidel M

    更新日期:1991-08-01 00:00:00

  • Colchicine alters apamin receptors, electrical activity, and skeletal muscle relaxation.

    abstract::A low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves, induced by colchicine, caused a transient increase in muscle ap...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Vergara C,Ramírez B,Behrens MI

    更新日期:1993-09-01 00:00:00

  • Homonymous and heteronymous monosynaptic reflexes in biceps brachii.

    abstract::Using poststimulus time histograms, it has been reported that stimulation of the median nerve at the elbow produces a monosynaptic EPSP in voluntarily active single motoneurons of the human biceps brachii. The present study was undertaken to: (i) determine whether such stimulation could evoke a reproducible reflex res...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Miller TA,Mogyoros I,Burke D

    更新日期:1995-06-01 00:00:00

  • Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy.

    abstract:INTRODUCTION:We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS:Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Markvardsen LH,Overgaard K,Heje K,Sindrup SH,Christiansen I,Vissing J,Andersen H

    更新日期:2018-01-01 00:00:00

  • Coping strategies in relation to quality of life in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:The aim of this study was to examine the coping strategies of 49 patients with amyotrophic lateral sclerosis (ALS) and the relationships of these strategies to their perceived health-related quality of life (HRQoL). METHODS:Forty-nine subjects were assessed for collection of demographic and medical data. ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Montel S,Albertini L,Spitz E

    更新日期:2012-01-01 00:00:00

  • Neurectomy preserves fast fibers when combined with tenotomy of infraspinatus muscle via upregulation of myogenesis.

    abstract:INTRODUCTION:We evaluated the contribution of denervation-related molecular processes to rotator cuff muscle degeneration after tendon release. METHODS:We assessed the levels of myogenic (myogenin and myogenic differentiation factor [myoD]) and proadipogenic (peroxisome proliferator-activated receptor γ) transcription...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Flück M,Valdivieso P,Ruoss S,von Rechenberg B,Benn MC,Meyer DC,Wieser K,Gerber C

    更新日期:2019-01-01 00:00:00

  • Electrical stimulation impairs early functional recovery and accentuates skeletal muscle atrophy after sciatic nerve crush injury in rats.

    abstract::Neuromuscular recovery after peripheral nerve lesion depends on the regeneration of severed axons that re-establish their functional connection with the denervated muscle. The aim of this study was to determine the effects of electrical stimulation (ES) on the neuromuscular recovery after nerve crush injury in rats. E...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Gigo-Benato D,Russo TL,Geuna S,Domingues NR,Salvini TF,Parizotto NA

    更新日期:2010-05-01 00:00:00

  • Contractile properties of human thenar muscles paralyzed by spinal cord injury.

    abstract::The electrical and mechanical properties of paralyzed human thenar muscles were measured in response to supramaximal stimulation of the median nerve in individuals with chronic cervical spinal cord injury. These data were compared to those recorded from control muscles. Spontaneous motor unit activity was common in pa...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Thomas CK

    更新日期:1997-07-01 00:00:00

  • Activity, molecular forms, and cytochemistry of cholinesterases in developing rat diaphragm.

    abstract::Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were studied in the diaphragm of early postnatal rats, using radiometric determination of enzyme activities, velocity sedimentation for separation of molecular forms, and electron microscopic cytochemistry to localize enzymes. AChE activity did not change s...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Brzin M,Sketelj J,Tennyson VM,Kiauta T,Budininkas-Schoenebeck M

    更新日期:1981-11-01 00:00:00

  • Contractile speed and fatigue of adductor pollicis muscle in multiple sclerosis.

    abstract::The purpose of the study was to investigate differences in contractile speed, force, and fatigability of the adductor pollicis muscle between 12 patients with multiple sclerosis (MS) and 8 sedentary control subjects matched for age and gender. There were no differences between the patients with MS and control subjects...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: de Ruiter CJ,Jongen PJ,van der Woude LH,de Haan A

    更新日期:2001-09-01 00:00:00

  • Seipin S90L mutation in an Italian family with CMT2/dHMN and pyramidal signs.

    abstract::Heterozygous mutations in the Berardinelli-Seip congenital lipodystrophy (BSCL2) gene have been associated with different clinical phenotypes including Silver syndrome/spastic paraplegia 17, distal hereditary motor neuropathy type V, and Charcot-Marie-Tooth disease type 2 (CMT2) with predominant hand involvement. We s...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Luigetti M,Fabrizi GM,Madia F,Ferrarini M,Conte A,Delgrande A,Tonali PA,Sabatelli M

    更新日期:2010-09-01 00:00:00

  • Changes in joint angle, muscle-tendon complex length, muscle contractile tissue displacement, and modulation of EMG activity during acute whole-body vibration.

    abstract::It has been suggested that vibration causes small changes in muscle length, but to the best of our knowledge, these have yet to be demonstrated during whole-body vibration (WBV). This was an observational study to determine whether acute WBV would result in muscle lengthening. We hypothesized that acute WBV would incr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Cochrane DJ,Loram ID,Stannard SR,Rittweger J

    更新日期:2009-09-01 00:00:00

  • Sensory (1a) and F-wave conduction velocity in the proximal segment of the tibial nerve.

    abstract::The F-wave was used to estimate the fastest motor nerve conduction velocity (MNCV) along the proximal segment (spinal cord to knee) of the axons of the tibial nerve in 65 control subjects, 8 patients with diabetic polyneuropathy, and 4 patients with Charcot-Marie-Tooth disease. Terminal latencies and MNCV along the di...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Panayiotopoulos CP,Scarpalezos S,Nastas PE

    更新日期:1978-05-01 00:00:00

  • Nemaline body myopathy caused by a novel mutation in troponin T1 (TNNT1).

    abstract:INTRODUCTION:Nemaline myopathy is a rare disorder characterized by skeletal muscle weakness of varying severity and onset, with the presence of nemaline rods on muscle biopsy. Congenital nemaline body myopathy due to mutations in TNNT1 has hitherto only been described as a result of a single founder mutation in patient...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Abdulhaq UN,Daana M,Dor T,Fellig Y,Eylon S,Schuelke M,Shaag A,Elpeleg O,Edvardson S

    更新日期:2016-04-01 00:00:00

  • Obturator neuropathy: causes and outcome.

    abstract::To study causes of obturator neuropathy and to correlate them with outcome, we retrospectively studied patients seen at the Mayo Clinic electromyography (EMG) laboratory from 1975 through 1999 with a diagnosis of obturator neuropathy. Twenty-two patients with obturator neuropathy were identified. The clinical outcome ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Sorenson EJ,Chen JJ,Daube JR

    更新日期:2002-04-01 00:00:00

  • Chronic immune sensorimotor polyradiculopathy: Report of a case series.

    abstract:INTRODUCTION:Chronic immune sensorimotor polyradiculopathy (CISMP) is a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) variant affecting both sensory and motor nerve roots without evidence of peripheral nerve demyelination. METHODS:We report a case series of 9 patients with CISMP, identified from 2 t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Thammongkolchai T,Suhaib O,Termsarasab P,Li Y,Katirji B

    更新日期:2019-06-01 00:00:00

  • Single motor unit H-reflex in motor neuron disorders.

    abstract::The latency fluctuation of single motor unit potentials (MUPH) in the H-reflex is greater than the latency fluctuation of MUPs in the direct (MUPM) and recurrent (MUPF) responses. This has been attributed to the variability in the impulse generation at the site of nerve stimulation, and to the variation in the synapti...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Soliven B,Maselli RA

    更新日期:1992-06-01 00:00:00

  • Clinical and genetic description of a family with Charcot-Marie-Tooth disease type 1B from a transmembrane MPZ mutation.

    abstract::Mutations in the myelin protein zero gene (MPZ) are associated with certain demyelinating neuropathies, and in particular with Charcot-Marie-Tooth disease type 1B (CMT1B), Dejerine-Sottas syndrome, and congenital hypomyelination. MPZ mutations affecting the protein's transmembrane domain are generally associated with ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Eggers SD,Keswani SC,Melli G,Cornblath DR

    更新日期:2004-06-01 00:00:00

  • Absence of anti-HMG-CoA reductase autoantibodies in severe self-limited statin-related myopathy.

    abstract:INTRODUCTION:Patients with self-limited statin-related myopathy improve spontaneously when statins are stopped. In contrast, patients with statin-associated autoimmune myopathy have autoantibodies recognizing 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) and usually require immunosuppressive therapy to contr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Floyd JS,Brody JA,Tiniakou E,Psaty BM,Mammen A

    更新日期:2016-06-01 00:00:00

  • Factors relating to gender specificity of unloading-induced declines in strength.

    abstract:INTRODUCTION:This investigation aimed to: (1) confirm whether women were more vulnerable to the negative neuromuscular adaptations elicited by muscle unloading and if so, (2) determine which physiological mechanism(s) explain those gender-related differences. METHODS:Healthy young men (20.7 ± 0.3 years) and women (20....

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Deschenes MR,McCoy RW,Mangis KA

    更新日期:2012-08-01 00:00:00

  • Hereditary neuropathy and vocal cord paralysis in a man with childhood diphtheria.

    abstract::We present the case of a 37-year-old Afghani man with a history of childhood diphtheria, who was diagnosed with bilateral vocal cord paralysis at age 15 years. At about this time he developed progressive muscular wasting and distally predominant weakness, and subsequently developed respiratory insufficiency, necessita...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Reichler BD,Scelsa SN,Simpson DM

    更新日期:2000-01-01 00:00:00

  • Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS). METHODS:We included 55 ALS pat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Schreiber S,Debska-Vielhaber G,Abdulla S,Machts J,Schreiber F,Kropf S,KÖrtvelyessy P,KÖrner S,Kollewe K,Petri S,Dengler R,Kunz WS,Nestor PJ,Vielhaber S

    更新日期:2018-02-01 00:00:00

  • Genetic variability and clinical spectrum of Chinese patients with limb-girdle muscular dystrophy type 2A.

    abstract:INTRODUCTION:Previous studies of limb-girdle muscular dystrophy type 2A (LGMD2A) patients in many countries have suggested a heterogeneous genetic and clinical spectrum, but the genotypes and phenotypes of Chinese LGMD2A patients remain unclear. METHODS:We directly screened calpain-3 (CAPN3) in 18 Chinese Han subjects...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Luo SS,Xi JY,Zhu WH,Zhao CB,Lu JH,Lin J,Wang Y,Lu J,Qiao K

    更新日期:2012-11-01 00:00:00

  • Therapeutic trial of isaxonine in Duchenne muscular dystrophy.

    abstract::A randomized double-blind therapeutic trial of isaxonine was completed over a 2-year period for 20 ambulant boys with Duchenne muscular dystrophy aged 5 1/2-10 years. The effect of the drug was monitored by measurement of walking times over 28 and 150 ft, motor ability score, MRC score based on 32 muscle groups, and m...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Heckmatt JZ,Hyde SA,Gabain A,Dubowitz V

    更新日期:1988-08-01 00:00:00

  • Impact of denervation-induced muscle atrophy on housekeeping gene expression in mice.

    abstract:INTRODUCTION:Immobilization induced by experimental denervation leads to rapid and progressive alterations in structural and biochemical properties of skeletal muscle. Real-time reverse transcription-polymerase chain reaction (RT-PCR) is a popular method of elucidating the molecular mechanisms involved in muscle atroph...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Nakao R,Yamamoto S,Yasumoto Y,Kadota K,Oishi K

    更新日期:2015-02-01 00:00:00

  • Ultrasound elastography assessment of the median nerve in leprosy patients.

    abstract:INTRODUCTION:We sought to compare median nerve elasticity between leprosy patients (LPs) and healthy volunteers (HVs) using ultrasound elastography (UE). METHODS:Two radiologists independently measured the strain ratio of the median nerve/flexor digitorum superficialis muscle (MN/FDSM) of 18 LP and 18 HV using real-ti...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Nogueira-Barbosa MH,Lugão HB,Gregio-Júnior E,Crema MD,Kobayashi MTT,Frade MAC,Pavan TZ,Carneiro AAO

    更新日期:2017-09-01 00:00:00