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Repeat structures in a Plasmodium falciparum protein (MESA) that binds human erythrocyte protein 4.1.

Abstract：

:The mature-parasite-infected erythrocyte surface antigen (MESA, also known as PfEMP-2 and pp300) of Plasmodium falciparum is a phosphoprotein of approx. 250-300 kDa that is exported from the parasite to the erythrocyte membrane skeleton where it binds to protein 4.1. Determination of the primary sequence of MESA reveals that it is encoded by 2 exons, a structure common to other exported proteins of P. falciparum. The MESA protein is heavily charged and contains 7 distinct repeat regions that compose over 60% of the protein. The predicted secondary structure suggests that MESA is a fibrillar protein and it shows similarity to a number of cytoskeletal and neurofilament proteins, including myosin, a protein that itself binds to protein 4.1.

journal_name

Mol Biochem Parasitol

journal_title

Molecular and biochemical parasitology

authors

Coppel RL

doi

10.1016/0166-6851(92)90231-8

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

335-47

issue

2

eissn

0166-6851

issn

1872-9428

pii

0166-6851(92)90231-8

journal_volume

50

pub_type

杂志文章

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