Abstract:
:Seven beta-naphthylamine-linked peptides were tested as substrates for a previously described thiol proteinase of adult Schistosoma mansoni. The enzyme was not active on carbobenoxy-arginyl-arginyl-4-methoxy-2-naphthylamide and carbobenzoxy-alanyl-arginyl-arginyl-4-methoxy-2-naphthylamide. Enzyme activity was maximal at acidic pH (4.9-5.5) with similar optima for both macromolecular and peptide substrates. Activity of partially purified enzyme preparations against carbobenzoxy-arginyl-arginyl-4-methoxy-2-naphthylamide was stimulated more than 10-fold by thiols. The properties of this proteinase differ from those of proteolytic enzymes from the cercariae ad eggs of S. mansoni.
journal_name
Mol Biochem Parasitoljournal_title
Molecular and biochemical parasitologyauthors
Dresden MH,Rutledge ML,Chappell CLdoi
10.1016/0166-6851(81)90029-3subject
Has Abstractpub_date
1981-11-01 00:00:00pages
61-6issue
1-2eissn
0166-6851issn
1872-9428pii
0166-6851(81)90029-3journal_volume
4pub_type
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