Abstract:
:Mucopolysaccharidosis type IV A (MPS IV A) is an autosomal recessive disorder resulting from the deficient activity of the lysosomal enzyme, N-acetylgalactosamine-6-sulfate sulfatase (GALNS) and the progressive lysosomal accumulation of keratane sulfate. Clinically, the MPS IV A differs from the other MPS by the localisation of the keratane sulfate in skelet and in eyes associated to the conservation of a normal intelligence. To date, the characterization and purification of the GALNS gene made a research for pathogenic mutations in patients with MPS IV A easier. These mutations are responsible of severe, intermediate or mild phenotype. The aim for this work was the research of clinical, biologic and molecular characteristics of two Tunisian MPS IV A patients who were offsprings of consanguineous mating. Enzymatic and urinary diagnostics suggested a MPS IV A phenotype. A novel homozygous mutation IVS1+1G-A was identified by direct sequencing in the GALNS gene of the two patients. Identification of GALNS mutations provide genotype/phenotype correlations and permit the precision of anomalies responsible of Morquio A phenotype in concerned families.
journal_name
Ann Biol Clin (Paris)journal_title
Annales de biologie cliniqueauthors
Khedhiri S,Chkioua L,Ferchichi S,Bouzidi H,Haj Khelil A,Ben Mansour R,Kassab A,M'dallah S,Chaabouni M,Jrad T,Ben Chibani J,Miled A,Laradi Ssubject
Has Abstractpub_date
2007-01-01 00:00:00pages
59-63issue
1eissn
0003-3898issn
1950-6112journal_volume
65pub_type
杂志文章abstract::Community viral bronchopneumonias are frequent, mainly in children, and can be associated to all respiratory viruses: influenza- and parainfluenzavirus, respiratory syncytial virus, adenovirus, rhinovirus. The diagnostic method which proves viral infection of the respiratory tissues is selected as the direct detection...
journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
doi:
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
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journal_title:Annales de biologie clinique
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doi:
更新日期:1983-01-01 00:00:00
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2013.0922
更新日期:2014-01-01 00:00:00
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journal_title:Annales de biologie clinique
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更新日期:2006-03-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2017.1225
更新日期:2017-04-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
doi:10.1684/abc.2008.0227
更新日期:2008-05-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
doi:
更新日期:2004-09-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2018.1384
更新日期:2018-12-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章,评审
doi:
更新日期:1978-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2011.0536
更新日期:2011-03-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2015.1036
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2014.0944
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
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journal_title:Annales de biologie clinique
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Annales de biologie clinique
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doi:
更新日期:1988-01-01 00:00:00
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journal_title:Annales de biologie clinique
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doi:
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2010.0405
更新日期:2010-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
doi:10.1684/abc.2013.0847
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journal_title:Annales de biologie clinique
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更新日期:1991-01-01 00:00:00
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journal_title:Annales de biologie clinique
pub_type: 杂志文章
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