Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys.

Abstract:

OBJECTIVE:This longitudinal study examined whether responsiveness of the neurotransmitter serotonin (5-HT) in childhood predicts adolescent aggression. METHOD:Boys (N = 33) with disruptive behavior disorders who received assessments of central 5-HT function via the prolactin response to fenfluramine between 1990 and 1994 when they were 7 to 11 years old were re-evaluated clinically on average 6.7 years later. RESULTS:After accounting for baseline aggression, early 5-HT function accounted for a significant proportion of variance in adolescent aggression. This prospective relationship of childhood 5-HT function with adolescent aggression (r = -0.71) and antisocial behavior (r = -0.59) was found primarily in adolescents who were aggressive during childhood. Irrespective of childhood aggression, no child with high 5-HT function was particularly aggressive at follow-up. CONCLUSIONS:Low childhood 5-HT function appears important, but not sufficient, for the emergence of adolescent aggression. However, early high 5-HT function may protect against adolescent violence and aggression.

authors

Halperin JM,Kalmar JH,Schulz KP,Marks DJ,Sharma V,Newcorn JH

doi

10.1097/01.chi.0000220855.79144.ae

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

833-40

issue

7

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)61530-6

journal_volume

45

pub_type

杂志文章
  • A secular increase in child and adolescent onset affective disorder.

    abstract::Both longitudinal and cross-sectional studies utilizing population and family study samples have found evidence for a secular increase in major affective disorders in adults. Applying techniques used in cross-sectional studies in adults to family study data of children and adolescents, the authors demonstrate evidence...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199207000-00004

    authors: Ryan ND,Williamson DE,Iyengar S,Orvaschel H,Reich T,Dahl RE,Puig-Antich J

    更新日期:1992-07-01 00:00:00

  • Methylphenidate and behavior modification in children with ADHD and comorbid ODD or CD: main and incremental effects across settings.

    abstract:OBJECTIVE:Although the combination of methylphenidate (MPH) and behavior modification (BMOD) has been advocated to enhance clinical outcome for children with attention-deficit hyperactivity disorder (ADHD) and comorbid disruptive disorders, few group studies have been conducted. This study evaluates the separate and in...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199905000-00020

    authors: Kolko DJ,Bukstein OG,Barron J

    更新日期:1999-05-01 00:00:00

  • Mechanisms of Change in the Prevention of Depression: An Indicated School-Based Prevention Trial at the Transition to High School.

    abstract:OBJECTIVE:Depression represents a major public health concern, and prevalence increases significantly during adolescence. The high school transition may exacerbate the risk of depression for youth with pre-existing vulnerability. The High School Transition Program (HSTP) is a brief, skills-based intervention that has d...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2019.05.031

    authors: Blossom JB,Adrian MC,Stoep AV,McCauley E

    更新日期:2020-04-01 00:00:00

  • Children's discrimination of expressions of emotions: relationship with indices of social anxiety and shyness.

    abstract:OBJECTIVE:To conduct an exploratory investigation of possible relationships between individual levels of social anxiety and the ability to classify emotional expressions in a group of schoolchildren observing pictures of children of similar age. METHOD:One hundred forty-nine second- and third-grade schoolchildren unde...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200403000-00019

    authors: Battaglia M,Ogliari A,Zanoni A,Villa F,Citterio A,Binaghi F,Fossati A,Maffei C

    更新日期:2004-03-01 00:00:00

  • Further evidence of a bidirectional overlap between juvenile mania and conduct disorder in children.

    abstract:OBJECTIVE:To investigate systematically the overlap between mania and conduct disorder (CD) in a sample of consecutively referred youths. It was hypothesized that neither CD nor manic symptoms were secondary to the other disorder and that children with the 2 disorders would have correlates of both. METHOD:Subjects wer...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199904000-00021

    authors: Biederman J,Faraone SV,Chu MP,Wozniak J

    更新日期:1999-04-01 00:00:00

  • Psychiatric comorbidity and the 16-month trajectory of substance-abusing and substance-dependent juvenile offenders.

    abstract:OBJECTIVES:To examine the concurrent correlates of internalizing and externalizing disorders among substance-abusing and substance-dependent juvenile offenders and to determine the association between psychiatric comorbidity and psychosocial functioning of the youths 16 months later. METHOD:Participants were 118 juven...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199909000-00015

    authors: Randall J,Henggeler SW,Pickrel SG,Brondino MJ

    更新日期:1999-09-01 00:00:00

  • Sex Differences in the Relationship Between Conduct Disorder and Cortical Structure in Adolescents.

    abstract:OBJECTIVE:Previous studies have reported reduced cortical thickness and surface area and altered gyrification in frontal and temporal regions in adolescents with conduct disorder (CD). Although there is evidence that the clinical phenotype of CD differs between males and females, no studies have examined whether such s...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jaac.2017.05.015

    authors: Smaragdi A,Cornwell H,Toschi N,Riccelli R,Gonzalez-Madruga K,Wells A,Clanton R,Baker R,Rogers J,Martin-Key N,Puzzo I,Batchelor M,Sidlauskaite J,Bernhard A,Martinelli A,Kohls G,Konrad K,Baumann S,Raschle N,Stadler C

    更新日期:2017-08-01 00:00:00

  • Cognitive-behavioral family treatment of childhood obsessive-compulsive disorder: a controlled trial.

    abstract:OBJECTIVE:To evaluate the relative efficacy of (1) individual cognitive-behavioral family-based therapy (CBFT); (2) group CBFT; and (3) a waitlist control group in the treatment of childhood obsessive-compulsive disorder (OCD). METHOD:This study, conducted at a university clinic in Brisbane, Australia, involved 77 chi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-200401000-00014

    authors: Barrett P,Healy-Farrell L,March JS

    更新日期:2004-01-01 00:00:00

  • Monoamine oxidase inhibitor toxicity.

    abstract::Monoamine oxidase inhibitor (MAOI) drugs are used in the treatment of depressive and anxiety disorders in adults. MAOIs are also used in high doses for the treatment of lymphomas and of central nervous system (CNS) tumors in children. Toxic effects resulted when procarbazine, a drug of this class, was used in treating...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-198911000-00024

    authors: Pfefferbaum B,Pack R,van Eys J

    更新日期:1989-11-01 00:00:00

  • Maternal characteristics and perceptions of pervasive and situational hyperactives and normal controls.

    abstract::Thirty 6- to 9-year-old boys were rated by their mothers and teachers as being pervasively hyperactive, situationally hyperactive, or not hyperactive at home or school. Maternal characteristics and perceptions of their children's behavior problems were collected. Children's global and molecular social skills were also...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199007000-00008

    authors: Beck SJ,Young GH,Tarnowski KJ

    更新日期:1990-07-01 00:00:00

  • Predicting methylphenidate response in children with ADHD: theoretical, empirical, and conceptual models.

    abstract:OBJECTIVE:To evaluate the theoretical merit and empirical validity of models designed to predict response to methylphenidate (MPH) among children with attention-deficit/hyperactivity disorder (ADHD). METHOD:Seventy-six children with ADHD received each of 4 counterbalanced doses of MPH (5, 10, 15, and 20 mg) in the con...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199904000-00011

    authors: Denney CB,Rapport MD

    更新日期:1999-04-01 00:00:00

  • Short-term outcome of major depression: I. Comorbidity and severity at presentation as predictors of persistent disorder.

    abstract:OBJECTIVE:To determine whether there is a pattern of clinical characteristics at presentation that specifically predicts persistent major depression at 36 weeks follow-up. METHOD:Sixty-eight consecutive cases with a first episode DSM-III-R diagnosis of major depression were interviewed with the Schedule for Affective ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199702000-00008

    authors: Goodyer IM,Herbert J,Secher SM,Pearson J

    更新日期:1997-02-01 00:00:00

  • Reported maltreatment among clinic-referred children: implications for presenting problems, treatment attrition, and long-term outcomes.

    abstract:OBJECTIVE:To examine the treatment implications of a reported history of maltreatment in a sample of 343 children referred to Los Angeles area mental health clinics for emotional and behavioral problems. METHOD:Child Protective Service records identified 161 of the 343 families as having a documented history of maltre...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000085754.71002.14

    authors: Lau AS,Weisz JR

    更新日期:2003-11-01 00:00:00

  • Reversibility of cardiac abnormalities in adolescents with anorexia nervosa after weight recovery.

    abstract:OBJECTIVE:Anorexia nervosa is a life-threatening condition, with significant risk for death due to cardiac complications. The objective of this study was to analyze the cardiac involvement in anorexia nervosa and to study the reversibility of cardiac abnormalities. METHOD:Thirty-one consecutive adolescents (aged 12 to...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000046867.56865.EB

    authors: Mont L,Castro J,Herreros B,Paré C,Azqueta M,Magriña J,Puig J,Toro J,Brugada J

    更新日期:2003-07-01 00:00:00

  • Child and adolescent psychiatrists' practices in assisting their adolescent patients who smoke to quit smoking.

    abstract:OBJECTIVE:This national study examined the practices and perceptions of smoking cessation activities among child and adolescent psychiatrists. METHOD:A random sample of child and adolescent psychiatrists was identified from the membership list of the American Academy of Child and Adolescent Psychiatry and was mailed a...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000242246.07797.c3

    authors: Price JH,Sidani JE,Price JA

    更新日期:2007-01-01 00:00:00

  • Effects of desipramine on autonomic control of the heart.

    abstract:OBJECTIVE:To assess the effects of desipramine (DMI) on autonomic control of the heart. METHODS:Blood pressure, RR interval (the time between successive heart beats), and RR interval variability, a noninvasive measure of autonomic control of the heart, were assessed in 13 subjects younger than 30 years old. RESULTS:D...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199402000-00006

    authors: Walsh BT,Giardina EG,Sloan RP,Greenhill L,Goldfein J

    更新日期:1994-02-01 00:00:00

  • Moral-emotional responsiveness: a two-factor domain of conscience functioning.

    abstract:OBJECTIVE:The purpose of this study was to assess the progression in development of moral-emotional responsiveness in children and adolescents and to examine the relationship of this progression with previously identified stages of conceptualization of conscience. METHOD:Using three semistructured questions from the S...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199401000-00017

    authors: Stilwell BM,Galvin M,Kopta SM,Norton JA Jr

    更新日期:1994-01-01 00:00:00

  • Mental health need and access to mental health services by youths involved with child welfare: a national survey.

    abstract:OBJECTIVE:This study assessed the relationship between the need for and use of mental health services among a nationally representative sample of children who were investigated by child welfare agencies after reported maltreatment. METHOD:Data were collected at study entry into the National Survey of Child and Adolesc...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000127590.95585.65

    authors: Burns BJ,Phillips SD,Wagner HR,Barth RP,Kolko DJ,Campbell Y,Landsverk J

    更新日期:2004-08-01 00:00:00

  • Another sudden death in a child treated with desipramine.

    abstract::The sudden death of three children receiving the tricyclic antidepressant medication desipramine for behavioral disorders was reported in 1990. We now provide new information about these children and describe a fourth case. Because desipramine is a useful medication for many children, these deaths pose clinical dilemm...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1097/00004583-199307000-00013

    authors: Riddle MA,Geller B,Ryan N

    更新日期:1993-07-01 00:00:00

  • The Quebec Adolescent Refugee Project: psychopathology and family variables in a sample from 35 nations.

    abstract:OBJECTIVE:This study presents the results of a psychiatric epidemiological survey using a sample of adolescents from refugee families. METHOD:The sample included 203 adolescents, aged 13 to 19 years, coming from 35 countries. Psychopathology was assessed with the Diagnostic Interview Schedule for Children Version 2.25...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199911000-00018

    authors: Tousignant M,Habimana E,Biron C,Malo C,Sidoli-LeBlanc E,Bendris N

    更新日期:1999-11-01 00:00:00

  • Effects of emotion on perceptual asymmetry in adolescent inpatients with attention-deficit hyperactivity disorder.

    abstract:OBJECTIVE:The authors studied the hemispheric functioning of adolescents with attention-deficit hyperactivity disorder (ADHD) in relation to this group's response to positively toned emotional stimuli. METHOD:Dichotic word tests were used to measure perceptual asymmetry in 21 adolescent inpatients and 24 control subje...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199303000-00012

    authors: Becker DF,Doane JA,Wexler BE

    更新日期:1993-03-01 00:00:00

  • A Multisite Study of Family Functioning Impairment in Pediatric Obsessive-Compulsive Disorder.

    abstract:OBJECTIVE:Familial aspects of pediatric obsessive-compulsive disorder (OCD), including accommodation and treatment, have received notable and warranted attention. However, individual perspectives of its repercussions on family functioning, including emotional and occupational parental burden, have not been closely exam...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jaac.2016.12.012

    authors: Stewart SE,Hu YP,Leung A,Chan E,Hezel DM,Lin SY,Belschner L,Walsh C,Geller DA,Pauls DL

    更新日期:2017-03-01 00:00:00

  • A randomized placebo-controlled trial of a school-based depression prevention program.

    abstract:OBJECTIVE:To conduct a placebo-controlled study of the effectiveness of a universal school-based depression prevention program. METHOD:Three hundred ninety-two students age 13 to 15 from two schools were randomized to intervention (RAP-Kiwi) and placebo programs run by teachers. RAP-Kiwi was an 11-session manual-based...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-200405000-00007

    authors: Merry S,McDowell H,Wild CJ,Bir J,Cunliffe R

    更新日期:2004-05-01 00:00:00

  • Editorial: Important First Look at Population-Based Trajectories of Youths With Autism.

    abstract::Few studies have followed young people with autism spectrum disorder (shortened to "autism" herein) over time, and all previous longitudinal studies have used clinical or center-based samples,1,2 leaving considerable uncertainty about the course of autism in the general population. In this issue, Simonoff and colleagu...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 社论

    doi:10.1016/j.jaac.2020.06.011

    authors: McGuire K,Veenstra-VanderWeele J

    更新日期:2020-12-01 00:00:00

  • Depressive disorders in maltreated children.

    abstract::This study examined the prevalence of depressive disorders in a sample of 56 7- to 12-year-old maltreated children. Overall, 18% of the sample met the diagnostic criteria for major depression, and 25% met the criteria for dysthymia, with the majority of the children who met the criteria for major depression also meeti...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199103000-00014

    authors: Kaufman J

    更新日期:1991-03-01 00:00:00

  • Obsessive-compulsive disorder in children and adolescents: a review of the past 10 years.

    abstract:OBJECTIVE:To review the literature on pediatric obsessive-compulsive disorder (OCD) from the perspective of information relevant to American Board of Psychiatry and Neurology recertification in child and adolescent psychiatry. METHOD:The clinical and research literatures were systematically searched or articles that a...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1097/00004583-199610000-00012

    authors: March JS,Leonard HL

    更新日期:1996-10-01 00:00:00

  • Case series: spectrum of neuroleptic-induced movement disorders and extrapyramidal side effects in childhood-onset schizophrenia.

    abstract:OBJECTIVE:Neuroleptic-treated pediatric patients with childhood-onset schizophrenia (COS) are at risk for developing extrapyramidal side effects and involuntary movement disorders. A preliminary examination of the incidence of withdrawal dyskinesias (WD), tardive dyskinesia (TD), and extrapyramidal side effects in thes...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-199802000-00016

    authors: Kumra S,Jacobsen LK,Lenane M,Smith A,Lee P,Malanga CJ,Karp BI,Hamburger S,Rapoport JL

    更新日期:1998-02-01 00:00:00

  • Applicability of personality disorder criteria to hospitalized adolescents: evaluation of internal consistency and criterion overlap.

    abstract:OBJECTIVE:The authors examined the applicability of personality disorder criteria to adolescent inpatients by evaluating internal consistency and criterion overlap. METHOD:Thirty-eight adolescents and 28 adults were assessed with the Personality Disorder Examination. Within-category cohesiveness (internal consistency)...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-199902000-00020

    authors: Becker DF,Grilo CM,Morey LC,Walker ML,Edell WS,McGlashan TH

    更新日期:1999-02-01 00:00:00

  • The impact of case definition on attention-deficit/hyperactivity disorder prevalence estimates in community-based samples of school-aged children.

    abstract:OBJECTIVE:To determine the impact of varying attention-deficit/hyperactivity disorder (ADHD) diagnostic criteria, including new DSM-5 criteria, on prevalence estimates. METHOD:Parent and teacher reports identified high- and low-screen children with ADHD from elementary schools in 2 states that produced a diverse overa...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2014.10.014

    authors: McKeown RE,Holbrook JR,Danielson ML,Cuffe SP,Wolraich ML,Visser SN

    更新日期:2015-01-01 00:00:00

  • Cognitive-behavioral therapy for adolescent depression: a meta-analytic investigation of changes in effect-size estimates.

    abstract:OBJECTIVE:To explicate differences between early and recent meta-analytic estimates of the effects of cognitive-behavioral therapy (CBT) for adolescent depression. METHOD:Meta-analytic procedures were used to investigate whether methodological characteristics moderated mean effect sizes among 11 randomized, controlled...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1097/chi.0b013e3180592aaa

    authors: Klein JB,Jacobs RH,Reinecke MA

    更新日期:2007-11-01 00:00:00