Abstract:
OBJECTIVE:This longitudinal study examined whether responsiveness of the neurotransmitter serotonin (5-HT) in childhood predicts adolescent aggression. METHOD:Boys (N = 33) with disruptive behavior disorders who received assessments of central 5-HT function via the prolactin response to fenfluramine between 1990 and 1994 when they were 7 to 11 years old were re-evaluated clinically on average 6.7 years later. RESULTS:After accounting for baseline aggression, early 5-HT function accounted for a significant proportion of variance in adolescent aggression. This prospective relationship of childhood 5-HT function with adolescent aggression (r = -0.71) and antisocial behavior (r = -0.59) was found primarily in adolescents who were aggressive during childhood. Irrespective of childhood aggression, no child with high 5-HT function was particularly aggressive at follow-up. CONCLUSIONS:Low childhood 5-HT function appears important, but not sufficient, for the emergence of adolescent aggression. However, early high 5-HT function may protect against adolescent violence and aggression.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Halperin JM,Kalmar JH,Schulz KP,Marks DJ,Sharma V,Newcorn JHdoi
10.1097/01.chi.0000220855.79144.aesubject
Has Abstractpub_date
2006-07-01 00:00:00pages
833-40issue
7eissn
0890-8567issn
1527-5418pii
S0890-8567(09)61530-6journal_volume
45pub_type
杂志文章abstract::Both longitudinal and cross-sectional studies utilizing population and family study samples have found evidence for a secular increase in major affective disorders in adults. Applying techniques used in cross-sectional studies in adults to family study data of children and adolescents, the authors demonstrate evidence...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199207000-00004
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:Although the combination of methylphenidate (MPH) and behavior modification (BMOD) has been advocated to enhance clinical outcome for children with attention-deficit hyperactivity disorder (ADHD) and comorbid disruptive disorders, few group studies have been conducted. This study evaluates the separate and in...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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abstract:OBJECTIVE:To conduct an exploratory investigation of possible relationships between individual levels of social anxiety and the ability to classify emotional expressions in a group of schoolchildren observing pictures of children of similar age. METHOD:One hundred forty-nine second- and third-grade schoolchildren unde...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
doi:10.1097/00004583-200403000-00019
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abstract:OBJECTIVE:To investigate systematically the overlap between mania and conduct disorder (CD) in a sample of consecutively referred youths. It was hypothesized that neither CD nor manic symptoms were secondary to the other disorder and that children with the 2 disorders would have correlates of both. METHOD:Subjects wer...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199904000-00021
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:To examine the concurrent correlates of internalizing and externalizing disorders among substance-abusing and substance-dependent juvenile offenders and to determine the association between psychiatric comorbidity and psychosocial functioning of the youths 16 months later. METHOD:Participants were 118 juven...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199909000-00015
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:Previous studies have reported reduced cortical thickness and surface area and altered gyrification in frontal and temporal regions in adolescents with conduct disorder (CD). Although there is evidence that the clinical phenotype of CD differs between males and females, no studies have examined whether such s...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究
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更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the relative efficacy of (1) individual cognitive-behavioral family-based therapy (CBFT); (2) group CBFT; and (3) a waitlist control group in the treatment of childhood obsessive-compulsive disorder (OCD). METHOD:This study, conducted at a university clinic in Brisbane, Australia, involved 77 chi...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-200401000-00014
更新日期:2004-01-01 00:00:00
abstract::Monoamine oxidase inhibitor (MAOI) drugs are used in the treatment of depressive and anxiety disorders in adults. MAOIs are also used in high doses for the treatment of lymphomas and of central nervous system (CNS) tumors in children. Toxic effects resulted when procarbazine, a drug of this class, was used in treating...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199007000-00008
更新日期:1990-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the theoretical merit and empirical validity of models designed to predict response to methylphenidate (MPH) among children with attention-deficit/hyperactivity disorder (ADHD). METHOD:Seventy-six children with ADHD received each of 4 counterbalanced doses of MPH (5, 10, 15, and 20 mg) in the con...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-199904000-00011
更新日期:1999-04-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199702000-00008
更新日期:1997-02-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.CHI.0000085754.71002.14
更新日期:2003-11-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:This national study examined the practices and perceptions of smoking cessation activities among child and adolescent psychiatrists. METHOD:A random sample of child and adolescent psychiatrists was identified from the membership list of the American Academy of Child and Adolescent Psychiatry and was mailed a...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.chi.0000242246.07797.c3
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To assess the effects of desipramine (DMI) on autonomic control of the heart. METHODS:Blood pressure, RR interval (the time between successive heart beats), and RR interval variability, a noninvasive measure of autonomic control of the heart, were assessed in 13 subjects younger than 30 years old. RESULTS:D...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199402000-00006
更新日期:1994-02-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199401000-00017
更新日期:1994-01-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/01.chi.0000127590.95585.65
更新日期:2004-08-01 00:00:00
abstract::The sudden death of three children receiving the tricyclic antidepressant medication desipramine for behavioral disorders was reported in 1990. We now provide new information about these children and describe a fourth case. Because desipramine is a useful medication for many children, these deaths pose clinical dilemm...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1097/00004583-199307000-00013
更新日期:1993-07-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199911000-00018
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:The authors studied the hemispheric functioning of adolescents with attention-deficit hyperactivity disorder (ADHD) in relation to this group's response to positively toned emotional stimuli. METHOD:Dichotic word tests were used to measure perceptual asymmetry in 21 adolescent inpatients and 24 control subje...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199303000-00012
更新日期:1993-03-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jaac.2016.12.012
更新日期:2017-03-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004583-200405000-00007
更新日期:2004-05-01 00:00:00
abstract::Few studies have followed young people with autism spectrum disorder (shortened to "autism" herein) over time, and all previous longitudinal studies have used clinical or center-based samples,1,2 leaving considerable uncertainty about the course of autism in the general population. In this issue, Simonoff and colleagu...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 社论
doi:10.1016/j.jaac.2020.06.011
更新日期:2020-12-01 00:00:00
abstract::This study examined the prevalence of depressive disorders in a sample of 56 7- to 12-year-old maltreated children. Overall, 18% of the sample met the diagnostic criteria for major depression, and 25% met the criteria for dysthymia, with the majority of the children who met the criteria for major depression also meeti...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1097/00004583-199103000-00014
更新日期:1991-03-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
doi:10.1097/00004583-199610000-00012
更新日期:1996-10-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
doi:10.1097/00004583-199802000-00016
更新日期:1998-02-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章
doi:10.1097/00004583-199902000-00020
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:To determine the impact of varying attention-deficit/hyperactivity disorder (ADHD) diagnostic criteria, including new DSM-5 criteria, on prevalence estimates. METHOD:Parent and teacher reports identified high- and low-screen children with ADHD from elementary schools in 2 states that produced a diverse overa...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章
doi:10.1016/j.jaac.2014.10.014
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To explicate differences between early and recent meta-analytic estimates of the effects of cognitive-behavioral therapy (CBT) for adolescent depression. METHOD:Meta-analytic procedures were used to investigate whether methodological characteristics moderated mean effect sizes among 11 randomized, controlled...
journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,meta分析
doi:10.1097/chi.0b013e3180592aaa
更新日期:2007-11-01 00:00:00