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Antidepressant withdrawal symptoms-telephone calls to a national medication helpline.

Abstract：

AIMS AND METHOD:Withdrawal symptoms are associated with cessation of all antidepressants but particularly paroxetine and venlafaxine. We aimed to examine rates of withdrawal symptoms reported to a national medication helpline over seven and a half year period. All calls reporting symptoms of antidepressant withdrawal were noted from a retrospective examination of contemporaneous handwritten records. RESULTS:Between October 1997 and March 2005, the national medication helpline received 22,422 calls of which 1753 (7.8%) concerned antidepressant discontinuation symptoms. Of these, 690 calls (39.36%) related to paroxetine and 252 (14.38%) to venlafaxine. Calls regarding paroxetine increased ten-fold in the month following a BBC 'Panorama' programme centring on problems associated with its use. Comparing number of calls with the number of prescriptions written over the same period revealed that MAOIs have the highest rate of reported reactions. CLINICAL IMPLICATIONS:Withdrawal symptoms were reported with nearly all antidepressants but most commonly with paroxetine and venlafaxine. Television programmes reporting adverse consequences of drug therapy can greatly increase reporting of discontinuation reactions. The highest rate of reporting adverse discontinuation symptoms was for MAOIs.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Taylor D,Stewart S,Connolly A

doi

10.1016/j.jad.2006.04.026

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

129-33

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(06)00212-6

journal_volume

95

pub_type

杂志文章

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