Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.


:The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.


Mol Cell Biol


Yu DH,Scorsone K,Hung MC




Has Abstract


1991-03-01 00:00:00












  • The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding.

    abstract::The ARK (AXL, UFO) receptor is a member of a new family of receptor tyrosine kinases whose extracellular domain contains a combination of fibronectin type III and immunoglobulin motifs similar to those found in many cell adhesion molecules. ARK mRNA is expressed at high levels in the mouse brain, prevalently in the hi...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Bellosta P,Costa M,Lin DA,Basilico C

    更新日期:1995-02-01 00:00:00

  • Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.

    abstract::Despite detailed knowledge of the components of the spindle assembly checkpoint, a molecular explanation of how cells die after prolonged spindle checkpoint activation, and thus how microtubule inhibitors and other antimitotic drugs ultimately elicit their lethal effects, has yet to emerge. Mitotically arrested cells ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Terrano DT,Upreti M,Chambers TC

    更新日期:2010-02-01 00:00:00

  • Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis.

    abstract::Cyclin B interacts with Cdc2 kinase to induce cell cycle events, particularly those of mitosis. The existence of cyclin B subtypes in several species has been known for some time, leading to speculation that key events of mitosis may be carried out by distinct functional classes of Cdc2/cyclin B. We report the discove...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Bueno A,Russell P

    更新日期:1993-04-01 00:00:00

  • PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.

    abstract::Members of the type II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors, retinoid X receptors [RXRs], vitamin D receptor, and the peroxisome proliferator-activated receptors) bind to their response sequences with or without ligand. In the absence of ligand, these DNA-b...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Mathur M,Tucker PW,Samuels HH

    更新日期:2001-04-01 00:00:00

  • Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth.

    abstract::Ras proteins can activate at least three classes of downstream target proteins: Raf kinases, phosphatidylinositol-3 phosphate (PI3) kinase, and Ral-specific guanine nucleotide exchange factors (Ral-GEFs). In NIH 3T3 cells, activated Ral-GEFs contribute to Ras-induced cell proliferation and oncogenic transformation by ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Goi T,Rusanescu G,Urano T,Feig LA

    更新日期:1999-03-01 00:00:00

  • LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein.

    abstract::The RBP-J/Su(H) DNA-binding protein plays a key role in transcriptional regulation by targeting Epstein-Barr virus nuclear antigen 2 (EBNA2) and the intracellular portions of Notch receptors to specific promoters. Using the yeast two-hybrid system, we isolated a LIM-only protein, KyoT, which physically interacts with ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Taniguchi Y,Furukawa T,Tun T,Han H,Honjo T

    更新日期:1998-01-01 00:00:00

  • Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.

    abstract::Transcriptional factors of the NFAT family play an important role in regulating the expression of several cytokine genes during the immune response, such as the genes for interleukin 2 (IL-2) and IL-4, among others. Upon antigen stimulation, precursor CD4+ T helper (pTh) cells proliferate and differentiate into two po...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Rincón M,Flavell RA

    更新日期:1997-03-01 00:00:00

  • Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation.

    abstract::Mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) lead to disrupted neuronal function and can cause the neurodevelopmental disorder Rett syndrome. MeCP2 is a transcriptional regulator that binds to methylated DNA and is most abundant in neuronal nuclei. The mechanisms by which MeCP2 regulates gene ex...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Gonzales ML,Adams S,Dunaway KW,LaSalle JM

    更新日期:2012-07-01 00:00:00

  • Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.

    abstract::Wnt glycoproteins play essential roles in the development of metazoan organisms. Many Wnt proteins, such as Wnt1, activate the well-conserved canonical Wnt signaling pathway, which results in accumulation of beta-catenin in the cytosol and nucleus. Other Wnts, such as Wnt5a, activate signaling mechanisms which do not ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: González-Sancho JM,Brennan KR,Castelo-Soccio LA,Brown AM

    更新日期:2004-06-01 00:00:00

  • Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.

    abstract::The high-affinity interleukin 2 receptor (IL-2R) consists of at least three distinct subunits: the IL-2R alpha chain (IL-2R alpha), beta chain (IL-2R beta), and gamma chain (IL-2R gamma). It has been shown that the cytoplasmic region of IL-2R beta, but not of IL-2R alpha, is essential for IL-2 signalling to the cell i...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Kawahara A,Minami Y,Taniguchi T

    更新日期:1994-08-01 00:00:00

  • A kinase-negative mutant of S49 mouse lymphoma cells is defective in posttranslational maturation of catalytic subunit of cyclic AMP-dependent protein kinase.

    abstract::Kinase-negative mutants of S49 mouse lymphoma cells, which lack detectable catalytic (C) subunit of cyclic AMP-dependent protein kinase, nevertheless contain cytoplasmic mRNAs for the two major forms of C subunit, C alpha and C beta. Investigation of the metabolism of C subunits in wild-type and mutant cells was under...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Steinberg RA

    更新日期:1991-02-01 00:00:00

  • Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.

    abstract::Transcription factor Nrf2 (NF-E2-related factor 2) is essential for oxidative and electrophilic stress responses. While it has been well characterized that Nrf2 activity is tightly regulated at the protein level through proteasomal degradation via Keap1 (Kelch-like ECH-associated protein 1)-mediated ubiquitination, no...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Suzuki T,Shibata T,Takaya K,Shiraishi K,Kohno T,Kunitoh H,Tsuta K,Furuta K,Goto K,Hosoda F,Sakamoto H,Motohashi H,Yamamoto M

    更新日期:2013-06-01 00:00:00

  • Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor.

    abstract::The ligand-binding domains of thyroid hormone (L-triiodothyronine [T3]) receptors (T3Rs), all-trans retinoic acid (RA) receptors (RARs), and 9-cis RA receptors (RARs and RXRs) contain a series of heptad motifs thought to be important for dimeric interactions. Using a chimera containing amino acids 120 to 392 of chicke...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Casanova J,Helmer E,Selmi-Ruby S,Qi JS,Au-Fliegner M,Desai-Yajnik V,Koudinova N,Yarm F,Raaka BM,Samuels HH

    更新日期:1994-09-01 00:00:00

  • Molecular analysis of the distal enhancer of the mouse alpha-fetoprotein gene.

    abstract::The mouse alpha-fetoprotein (AFP) gene is transcribed at high levels in the visceral endoderm of the yolk sac and fetal liver and at much lower rates in the endoderm of the fetal gut. Expression of the gene in vivo requires the presence of at least one of three enhancers which lie in its 5' flanking region. In this re...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Millonig JH,Emerson JA,Levorse JM,Tilghman SM

    更新日期:1995-07-01 00:00:00

  • The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development.

    abstract::The transcriptional coactivator BOB.1/OBF.1 confers B-cell specificity on the transcription factors Oct1 and Oct2 at octamer site-containing promoters. A hallmark of the BOB.1/OBF.1 mutation in the mouse is the absence of germinal center development in secondary lymphoid organs, demonstrating the requirement for BOB.1...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Hess J,Nielsen PJ,Fischer KD,Bujard H,Wirth T

    更新日期:2001-03-01 00:00:00

  • Developmental regulation of human gamma-globin genes in transgenic mice.

    abstract::We report results showing that several gamma gene promoter elements participate in the developmental control of gamma-globin genes. Four gamma gene constructs with 5' truncated at -141, -201, -382, and -730 of the A gamma gene promoter linked to a micro locus control region (microLCR) cassette were used for production...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Stamatoyannopoulos G,Josephson B,Zhang JW,Li Q

    更新日期:1993-12-01 00:00:00

  • Construction and characterization of Chinese hamster cell EmtA EmtB double mutants.

    abstract::Starting with hybrid cell lines between a Chinese hamster cell EmtA mutant and a Chinese hamster cell EmtB mutant, we have constructed cell lines that are homozygous for mutant alleles at both the emtA locus and the emtB locus, by using a two-step segregation protocol. The EmtA EmtB double mutants are approximately 10...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Chang S,Wasmuth JJ

    更新日期:1983-05-01 00:00:00

  • Alternative splicing of a human alpha-tropomyosin muscle-specific exon: identification of determining sequences.

    abstract::The human alpha-tropomyosin gene hTMnm has two mutually exclusive versions of exon 5 (NM and SK), one of which is expressed specifically in skeletal muscle (exon SK). A minigene construct expresses only the nonmuscle (NM) isoform when transfected into COS-1 cells and both forms when transfected into myoblasts. Twenty-...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Graham IR,Hamshere M,Eperon IC

    更新日期:1992-09-01 00:00:00

  • Yeast intragenic transcriptional control: activation and repression sites within the coding region of the Saccharomyces cerevisiae LPD1 gene.

    abstract::Though widely recognized in higher eukaryotes, the regulation of Saccharomyces cerevisiae genes transcribed by RNA polymerase II by proteins that bind within the coding sequence remains largely speculative. We have shown for the LPD1 gene, encoding lipoamide dehydrogenase, that the coding sequence between +13 and +469...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Sinclair DA,Kornfeld GD,Dawes IW

    更新日期:1994-01-01 00:00:00

  • Inducible overexpression and secretion of int-1 protein.

    abstract::The int-1 proto-oncogene is a target for insertional activation of transcription by mouse mammary tumor virus in many murine mammary tumors. Whereas no expression of int-1 is seen in normal mammary tissue, int-1 RNA can be detected in normal mice in the neural tubes of midgestation embryos and in postmeiotic spermatoc...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Papkoff J

    更新日期:1989-08-01 00:00:00

  • Deletion of the laminin alpha4 chain leads to impaired microvessel maturation.

    abstract::The laminin alpha4 chain, a component of laminin-8 and -9, is expressed in basement membranes, such as those beneath endothelia, the perineurium of peripheral nerves, and around developing muscle fibers. Laminin alpha4-null mice presented with hemorrhages during the embryonic and neonatal period and had extensive blee...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Thyboll J,Kortesmaa J,Cao R,Soininen R,Wang L,Iivanainen A,Sorokin L,Risling M,Cao Y,Tryggvason K

    更新日期:2002-02-01 00:00:00

  • The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.

    abstract::c-sis/platelet-derived growth factor 2 (PDGF-2) is a prototype growth factor with transforming potential. The c-sis/PDGF-2 transcript contains a long 5' untranslated sequence (UTS) that is highly G.C rich. To examine the influence of this sequence on sis/PDGF-2 expression, we localized the c-sis/PDGF-2 promoter and us...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Rao CD,Pech M,Robbins KC,Aaronson SA

    更新日期:1988-01-01 00:00:00

  • Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.

    abstract::How early- and late-firing origins are selected on eukaryotic chromosomes is largely unknown. Here, we show that Mrc1, a conserved factor required for stabilization of stalled replication forks, selectively binds to the early-firing origins in a manner independent of Cdc45 and Hsk1 kinase in the fission yeast Schizosa...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Hayano M,Kanoh Y,Matsumoto S,Masai H

    更新日期:2011-06-01 00:00:00

  • Regulation of cellular morphology by the Rous sarcoma virus src gene: analysis of fusiform mutants.

    abstract::We have been interested in how Rous sarcoma virus (RSV) influences transformed cell morphology and compared the molecular properties of chicken embryo cells (CEC) infected with mutants of RSV that induce the fusiform transformed cell morphology with those of CEC infected by wild-type RSV, which induces the more normal...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Rohrschneider L,Reynolds S

    更新日期:1985-11-01 00:00:00

  • Identification of a sequence element from p53 that signals for Mdm2-targeted degradation.

    abstract::The binding of Mdm2 to p53 is required for targeting p53 for degradation. p73, however, binds to Mdm2 but is refractory to Mdm2-mediated degradation, indicating that binding to Mdm2 is not sufficient for degradation. By utilizing the structural homology between p53 and p73, we generated p53-p73 chimeras to determine t...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Gu J,Chen D,Rosenblum J,Rubin RM,Yuan ZM

    更新日期:2000-02-01 00:00:00

  • The notch intracellular domain can function as a coactivator for LEF-1.

    abstract::Notch signaling commences with two ligand-mediated proteolysis events that release the Notch intracellular domain, NICD, from the plasma membrane. NICD then translocates into the nucleus and interacts with the DNA binding protein CSL to activate transcription. We found that NICD expression also potentiates activity of...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Ross DA,Kadesch T

    更新日期:2001-11-01 00:00:00

  • Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

    abstract::We have used in vitro mutagenesis to examine in detail the roles of two modular protein domains, SH2 and SH3, in the regulation of the Abl tyrosine kinase. As previously shown, the SH3 domain suppresses an intrinsic transforming activity of the normally nontransforming c-Abl product in vivo. We show here that this inh...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Mayer BJ,Baltimore D

    更新日期:1994-05-01 00:00:00

  • mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells.

    abstract::mTOR coordinates growth signals with metabolic pathways and protein synthesis and is hyperactivated in many human cancers. mTOR exists in two complexes: mTORC1, which stimulates protein, lipid, and ribosome biosynthesis, and mTORC2, which regulates cytoskeleton functions. While mTOR is known to be involved in the DNA ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Silvera D,Ernlund A,Arju R,Connolly E,Volta V,Wang J,Schneider RJ

    更新日期:2017-02-15 00:00:00

  • Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1.

    abstract::The packaging of the eukaryotic genome into chromatin is likely to be important for the maintenance of genomic integrity. Chromatin structures are assembled onto newly synthesized DNA by the action of chromatin assembly factors, including anti-silencing function 1 (ASF1). To investigate the role of chromatin structure...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Ramey CJ,Howar S,Adkins M,Linger J,Spicer J,Tyler JK

    更新日期:2004-12-01 00:00:00

  • Homologous plasmid recombination is elevated in immortally transformed cells.

    abstract::The levels of intramolecular plasmid recombination, following transfection of a plasmid substrate for homologous recombination into normal and immortally transformed cells, have been examined by two independent assays. In the first assay, recovered plasmid was tested for DNA rearrangements which regenerate a functiona...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Finn GK,Kurz BW,Cheng RZ,Shmookler Reis RJ

    更新日期:1989-09-01 00:00:00