Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.

Abstract:

:The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.

journal_name

Mol Cell Biol

authors

Yu DH,Scorsone K,Hung MC

doi

10.1128/mcb.11.3.1745

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

1745-50

issue

3

eissn

0270-7306

issn

1098-5549

journal_volume

11

pub_type

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