Non-transferrin-bound iron and risk of coronary heart disease in postmenopausal women.

abstract：:Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...

journal_title：Circulation

authors： Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Postprandial angina pectoris has been recognized for more than two centuries and can be identified in up to 10% of patients with chronic ischemic heart disease. Redistribution of myocardial blood flow, from a region supplied by a severely stenotic coronary artery to those supplied by less diseased or normal ...

journal_title：Circulation

authors： Baliga RR,Rosen SD,Camici PG,Kooner JS

更新日期：1998-03-31 00:00:00

abstract：:The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...

journal_title：Circulation

authors： Quinn MJ,Fitzgerald DJ

更新日期：1999-10-12 00:00:00

abstract：BACKGROUND:High-speed rotational atherectomy uses a diamond-coated, elliptical burr to abrade occlusive atherosclerosis, especially noncompliant calcified plaque. METHODS AND RESULTS:Intravascular ultrasound (IVUS) was used to analyze 28 patients after atherectomy. Arteries treated and imaged were left main (three), l...

journal_title：Circulation

authors： Mintz GS,Potkin BN,Keren G,Satler LF,Pichard AD,Kent KM,Popma JJ,Leon MB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelle...

journal_title：Circulation

authors： Briley-Saebo KC,Shaw PX,Mulder WJ,Choi SH,Vucic E,Aguinaldo JG,Witztum JL,Fuster V,Tsimikas S,Fayad ZA

更新日期：2008-06-24 00:00:00

abstract：BACKGROUND:Fibrosis and progressive failure are prominent pathophysiological features of hearts after myocardial infarction (MI). We examined the effects of inhibiting transforming growth factor-beta (TGF-beta) signaling on post-MI cardiac fibrosis and ventricular remodeling and function. METHODS AND RESULTS:MI was in...

journal_title：Circulation

authors： Okada H,Takemura G,Kosai K,Li Y,Takahashi T,Esaki M,Yuge K,Miyata S,Maruyama R,Mikami A,Minatoguchi S,Fujiwara T,Fujiwara H

更新日期：2005-05-17 00:00:00

abstract：BACKGROUND:Cholesterol-lowering therapy can improve cardiovascular morbidity and mortality in patients with atherosclerosis. Although the mechanisms responsible are unclear, these benefits precede macroscopic changes in the vasculature. Emerging evidence that improvement in endothelial function may occur requires subst...

journal_title：Circulation

authors： O'Driscoll G,Green D,Taylor RR

更新日期：1997-03-04 00:00:00

abstract：BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...

journal_title：Circulation

authors： Arnese M,Cornel JH,Salustri A,Maat A,Elhendy A,Reijs AE,Ten Cate FJ,Keane D,Balk AH,Roelandt JR

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS:To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic cir...

journal_title：Circulation

authors： Nemmar A,Hoet PH,Vanquickenborne B,Dinsdale D,Thomeer M,Hoylaerts MF,Vanbilloen H,Mortelmans L,Nemery B

更新日期：2002-01-29 00:00:00

abstract：BACKGROUND:Direct thrombin inhibitors are a new class of drugs that may offer a more effective and potentially simpler alternative to heparin. Hirulog is a synthetic peptide based on the leech-derived compound hirudin and, like hirudin, is a highly specific, direct inhibitor of free and clot-bound thrombin. METHODS AN...

journal_title：Circulation

authors： Fuchs J,Cannon CP

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Sensitivity to apoptotic signals, the clearance rate of apoptosis, and the apoptotic ultrastructure have not been studied in cells of the in vivo adult heart. METHODS AND RESULTS:To minimize the systemic influence, soluble Fas ligand was injected directly into in vivo rat hearts and livers (as the control) ...

journal_title：Circulation

authors： Hayakawa K,Takemura G,Koda M,Kawase Y,Maruyama R,Li Y,Minatoguchi S,Fujiwara T,Fujiwara H

更新日期：2002-06-25 00:00:00

abstract：BACKGROUND:The number of CD4(+)CD28(null) (CD28(null)) T cells, a unique subset of T lymphocytes with proinflammatory and cell-lytic phenotype, increases markedly in patients with acute coronary syndrome (ACS). ACS patients harboring high numbers of CD28(null) T cells have increased risk of recurrent severe acute coron...

journal_title：Circulation

authors： Kovalcsik E,Antunes RF,Baruah P,Kaski JC,Dumitriu IE

更新日期：2015-02-24 00:00:00

abstract：:Diseases that cause symptoms incompletely relieved by available modes of treatment stimulate search for new therapies. Chronic disease processes, in which interventions are palliative rather than curative provide a particular challenge in determining the value of therapeutic intervention. Management of patients with a...

journal_title：Circulation

authors： Parisi AF,Strauss WE,McIntyre KM,Sasahara AA

更新日期：1982-01-01 00:00:00

abstract：:Six cases of classical dissecting aneurysm of the aorta complicating aortic valvular disease in which aortic stenosis was dominant are described. In three of the cases the aortic complication occurred after the natural aortic valve had been replaced by a prosthetic valve. The longest postoperative period was four mont...

journal_title：Circulation

authors： Fukuda T,Tadavarthy SM,Edwards JE

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to...

journal_title：Circulation

authors： Tang X,Chen XF,Wang NY,Wang XM,Liang ST,Zheng W,Lu YB,Zhao X,Hao DL,Zhang ZQ,Zou MH,Liu DP,Chen HZ

更新日期：2017-11-21 00:00:00

abstract：:The effect of acute alterations in coronary blood flow (CBF) on left ventricular (LV) end-diastolic wall thickness was measured by reflected ultrasound in twelve anesthetized dogs. During five minutes of coronary ligation, wall thickness decreased from a control of 9.0 +/- 0.3 mm to 8.1 +/- 0.3 mm (P less than 0.001);...

journal_title：Circulation

authors： Gaasch WH,Bernard SA

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:The ability of echocardiographic dyssynchrony to predict response to cardiac resynchronization therapy (CRT) has been unclear. METHODS AND RESULTS:A prospective, longitudinal study was designed with predefined dyssynchrony indexes and outcome variables to test the hypothesis that baseline dyssynchrony is as...

journal_title：Circulation

authors： Gorcsan J 3rd,Oyenuga O,Habib PJ,Tanaka H,Adelstein EC,Hara H,McNamara DM,Saba S

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:In recent clinical trials, glycoprotein IIb/IIIa blockers have demonstrated effectiveness in preventing adverse events after angioplasty in high-risk patients. However, uncertainty exists regarding the cost-effective selection of patients to receive antiplatelet therapy. METHODS AND RESULTS:All 4962 patient...

journal_title：Circulation

authors： Weintraub WS,Thompson TD,Culler S,Boccuzzi SJ,Becker ER,Kosinski AS,Mahoney E

更新日期：2000-07-25 00:00:00

abstract：BACKGROUND:CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogen...

journal_title：Circulation

authors： Jansson AM,Aukrust P,Ueland T,Smith C,Omland T,Hartford M,Caidahl K

更新日期：2009-06-30 00:00:00

abstract：:Acute aortic regurgitation was created experimentally in 21 mongrel dogs to examine the relationship of the regurgitant jet to observed echocardiographic findings. The direction of the regurgitant jet was studied by echo contrast injections in the aortic root. Diastolic fluttering of the anterior mitral leaflet (AML) ...

journal_title：Circulation

authors： Nakao S,Tanaka H,Tahara M,Yoshimura H,Sakurai S,Tei C,Kashima T

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:We have previously shown that hydrogen peroxide stimulates endothelial [Ca(2+)](i) oscillations. This study was performed to determine whether posthypoxic reoxygenation stimulates [Ca(2+)](i) oscillations in vascular endothelial cells. METHODS AND RESULTS:Hypoxia (glucose-free 95% N(2)/5% CO(2) bicarbonate ...

journal_title：Circulation

authors： Hu Q,Ziegelstein RC

更新日期：2000-11-14 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：:Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

journal_title：Circulation

authors： Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...

journal_title：Circulation

authors： Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

更新日期：1999-04-06 00:00:00

abstract：BACKGROUND:NAD(P)H oxidases are important sources of superoxide in the vasculature, the activity of which is associated with risk factors for human atherosclerosis. This study was designed to investigate the localization of superoxide production and the expression of the Nox family of NAD(P)H oxidase proteins (gp91phox...

journal_title：Circulation

authors： Sorescu D,Weiss D,Lassègue B,Clempus RE,Szöcs K,Sorescu GP,Valppu L,Quinn MT,Lambeth JD,Vega JD,Taylor WR,Griendling KK

更新日期：2002-03-26 00:00:00

abstract：BACKGROUND:Outcomes after percutaneous coronary interventions in diabetic patients are shadowed by the increased rate of recurrence compared with nondiabetic patients. METHODS AND RESULTS:We conducted a multicenter, randomized trial to demonstrate the efficacy of sirolimus-eluting stents compared with standard stents ...

journal_title：Circulation

authors： Sabaté M,Jiménez-Quevedo P,Angiolillo DJ,Gómez-Hospital JA,Alfonso F,Hernández-Antolín R,Goicolea J,Bañuelos C,Escaned J,Moreno R,Fernández C,Fernández-Avilés F,Macaya C,DIABETES Investigators.

更新日期：2005-10-04 00:00:00

abstract：BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...

journal_title：Circulation

authors： Ruel M,Chan V,Bédard P,Kulik A,Ressler L,Lam BK,Rubens FD,Goldstein W,Hendry PJ,Masters RG,Mesana TG

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the ...

journal_title：Circulation

authors： Keating M

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, thus justifying the interest in molecules with ancillary vasodilating properties. Nebivolol is a selective beta1-adrenoreceptor antagonist that releases nitric oxide (NO) through incompletely characterized mechanisms. We id...

journal_title：Circulation

authors： Dessy C,Saliez J,Ghisdal P,Daneau G,Lobysheva II,Frérart F,Belge C,Jnaoui K,Noirhomme P,Feron O,Balligand JL

更新日期：2005-08-23 00:00:00

abstract：BACKGROUND:Intentional weight loss is associated with lower risk of heart failure (HF) and atherosclerotic cardiovascular disease among patients with type 2 diabetes. However, the contribution of baseline measures and longitudinal changes in fat mass (FM), lean mass (LM), and waist circumference (WC) to the risk of HF ...

journal_title：Circulation

authors： Patel KV,Bahnson JL,Gaussoin SA,Johnson KC,Pi-Sunyer X,White U,Olson KL,Bertoni AG,Kitzman DW,Berry JD,Pandey A,Look AHEAD Research Group.

更新日期：2020-12-22 00:00:00