Randomized comparison of sirolimus-eluting stent versus standard stent for percutaneous coronary revascularization in diabetic patients: the diabetes and sirolimus-eluting stent (DIABETES) trial.


BACKGROUND:Outcomes after percutaneous coronary interventions in diabetic patients are shadowed by the increased rate of recurrence compared with nondiabetic patients. METHODS AND RESULTS:We conducted a multicenter, randomized trial to demonstrate the efficacy of sirolimus-eluting stents compared with standard stents to prevent restenosis in diabetic patients with de novo lesions in native coronary arteries. The primary end point of the trial was in-segment late lumen loss as assessed by quantitative coronary angiography at 9-month follow-up. The trial was stratified by diabetes treatment status. One hundred sixty patients were randomized to sirolimus-eluting stents (80 patients; 111 lesions) or standard stent implantation (80 patients; 110 lesions). On average, reference diameter was 2.34+/-0.6 mm, lesion length was 15.0+/-8 mm, and 13.1% of lesions were chronic total occlusions. In-segment late lumen loss was reduced from 0.47+/-0.5 mm for standard stents to 0.06+/-0.4 mm for sirolimus stents (P<0.001). Target-lesion revascularization and major adverse cardiac event rates were significantly lower in the sirolimus group (31.3% versus 7.3% and 36.3% versus 11.3%, respectively; both P<0.001). Non-insulin- and insulin-requiring patients demonstrated similar reductions in angiographic and clinical parameters of restenosis after sirolimus-eluting stent implantation. During the 9-month follow-up, stent thrombosis occurred in 2 patients after standard stent implantation. Conversely, this phenomenon was not seen in the sirolimus stent group. CONCLUSIONS:This randomized trial demonstrated that sirolimus stent implantation is safe and efficacious in reducing both angiographic and clinical parameters of restenosis compared with standard stents in diabetic patients with de novo coronary stenoses.






Sabaté M,Jiménez-Quevedo P,Angiolillo DJ,Gómez-Hospital JA,Alfonso F,Hernández-Antolín R,Goicolea J,Bañuelos C,Escaned J,Moreno R,Fernández C,Fernández-Avilés F,Macaya C,DIABETES Investigators.




Has Abstract


2005-10-04 00:00:00














  • Lipid lowering versus revascularization: an idea whose time (for testing) has come.

    abstract::There is strong evidence that revascularization does not prevent myocardial infarction in patients with stable coronary artery disease (CAD). The anatomic basis for this counterintuitive conclusion seems to be that most myocardial infarctions occur at sites that did not previously exhibit an angiographically significa...


    pub_type: 杂志文章


    authors: Forrester JS,Shah PK

    更新日期:1997-08-19 00:00:00

  • Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis.

    abstract:BACKGROUND:Endothelin-converting enzyme (ECE)-1 activates endothelin-1 (ET-1) and may thus contribute to the regulation of vascular tone and cell growth during atherosclerosis. METHODS AND RESULTS:To evaluate ECE-1 immunoreactivity concerning big ET-1/ET-1, we performed qualitative and quantitative immunohistochemistr...


    pub_type: 杂志文章


    authors: Ihling C,Szombathy T,Bohrmann B,Brockhaus M,Schaefer HE,Loeffler BM

    更新日期:2001-08-21 00:00:00

  • Influence of racial disparities in procedure use on functional status outcomes among patients with coronary artery disease.

    abstract:BACKGROUND:Although black cardiac patients receive fewer revascularization procedures than whites, it is unclear whether this has a detrimental impact on outcomes. The objective of our study was to compare 6-month functional status and angina outcomes among blacks and whites with documented coronary disease and to asse...


    pub_type: 杂志文章


    authors: Kaul P,Lytle BL,Spertus JA,DeLong ER,Peterson ED

    更新日期:2005-03-15 00:00:00

  • Mechanisms of ischemic preconditioning in rat hearts. Involvement of alpha 1B-adrenoceptors, pertussis toxin-sensitive G proteins, and protein kinase C.

    abstract:BACKGROUND:Ischemic preconditioning attenuates the effects of subsequent sustained ischemia by a mechanism involving adenosine and G proteins in several species. Adenosine is not involved in ischemic preconditioning of rat hearts, the mechanisms of which are poorly understood. METHODS AND RESULTS:Reduction of isometri...


    pub_type: 杂志文章


    authors: Hu K,Nattel S

    更新日期:1995-10-15 00:00:00

  • Pulmonary hyperinflation and left ventricular mass: the Multi-Ethnic Study of Atherosclerosis COPD Study.

    abstract:BACKGROUND:Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants of LV mass are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes in intrathoracic pressure that increase LV wall stres...


    pub_type: 杂志文章


    authors: Smith BM,Kawut SM,Bluemke DA,Basner RC,Gomes AS,Hoffman E,Kalhan R,Lima JA,Liu CY,Michos ED,Prince MR,Rabbani L,Rabinowitz D,Shimbo D,Shea S,Barr RG

    更新日期:2013-04-09 00:00:00

  • Spatial distribution of phase singularities in ventricular fibrillation.

    abstract:BACKGROUND:Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)-locations of ambiguous activation state-underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS for...


    pub_type: 杂志文章


    authors: Valderrábano M,Chen PS,Lin SF

    更新日期:2003-07-22 00:00:00

  • Sustained improvement in left ventricular function and mortality by intracoronary streptokinase administration during evolving myocardial infarction.

    abstract::One hundred eighty-eight patients with acute myocardial infarction were studied prospectively from August 1980 to September 1982. One hundred thirty-six of these patients were entered into a intracoronary streptokinase study after informed consent was obtained. The remaining 52 patients, who either met exclusion crite...


    pub_type: 杂志文章


    authors: Smalling RW,Fuentes F,Matthews MW,Freund GC,Hicks CH,Reduto LA,Walker WE,Sterling RP,Gould KL

    更新日期:1983-07-01 00:00:00

  • Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by 31P magnetic resonance spectroscopy.

    abstract:BACKGROUND:31P metabolite measurements in the human heart by magnetic resonance spectroscopy (MRS) have been reported previously. By use of a method in which metabolite content was quantified with reference to a standard located outside the chest, it has become possible to measure the content of phosphocreatine (PCr) a...


    pub_type: 杂志文章


    authors: Yabe T,Mitsunami K,Inubushi T,Kinoshita M

    更新日期:1995-07-01 00:00:00

  • Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplin

    abstract::The incidence of valvular heart disease is expected to increase over the next several decades as a large proportion of the US demographic advances into the later decades of life. At the same time, the next several years can be anticipated to bring a broad transition of surgical therapy to minimally invasive (minithora...


    pub_type: 杂志文章,评审


    authors: Rosengart TK,Feldman T,Borger MA,Vassiliades TA Jr,Gillinov AM,Hoercher KJ,Vahanian A,Bonow RO,O'Neill W,American Heart Association Council on Cardiovascular Surgery and Anesthesia.,American Heart Association Council on Clinical Card

    更新日期:2008-04-01 00:00:00

  • Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly.

    abstract:BACKGROUND:The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (> or =75 years of age). METHODS AND RESULTS:We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8+/-1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) ...


    pub_type: 杂志文章


    authors: Hachamovitch R,Kang X,Amanullah AM,Abidov A,Hayes SW,Friedman JD,Cohen I,Thomson LE,Germano G,Berman DS

    更新日期:2009-12-01 00:00:00

  • Parvovirus B19 infection mimicking acute myocardial infarction.

    abstract:BACKGROUND:Enteroviruses (EVs) and adenoviruses (ADVs) have been considered common causes of myocarditis and dilated cardiomyopathy. In the present study, we report on the association of parvovirus B19 (PVB19) genomes in the clinical setting of acute myocarditis. METHODS AND RESULTS:This study included 24 consecutive ...


    pub_type: 杂志文章


    authors: Kühl U,Pauschinger M,Bock T,Klingel K,Schwimmbeck CP,Seeberg B,Krautwurm L,Poller W,Schultheiss HP,Kandolf R

    更新日期:2003-08-26 00:00:00

  • Intracardiac, intravascular, two-dimensional, high-frequency ultrasound imaging of pulmonary artery and its branches in humans and animals.

    abstract::Intravascular ultrasound imaging is a promising new method for assessing vascular morphology. We evaluated the capability of intravascular ultrasound to quantify pulmonary artery (PA) morphology in vitro and explored the feasibility of in vivo PA imaging in animals and humans. In the in vitro study of 15 PA segments, ...


    pub_type: 杂志文章


    authors: Pandian NG,Weintraub A,Kreis A,Schwartz SL,Konstam MA,Salem DN

    更新日期:1990-06-01 00:00:00

  • Experience with bretylium tosylate by a hospital cardiac arrest team.

    abstract::The effect of bretylium tosylate (BT) was determined in 27 consecutive cases of resistant ventricular fibrillation (VF) encountered by a hospital cardiac arrest team. The VF was sustained and completely resistant to multiple injections of lidocaine, sequential DC shocks at 400 watt-sec and one or a combination of intr...


    pub_type: 杂志文章


    authors: Holder DA,Sniderman AD,Fraser G,Fallen EL

    更新日期:1977-03-01 00:00:00

  • Persistence of functional atrioventricular accessory pathways in postseptated embryonic avian hearts: implications for morphogenesis and functional maturation of the cardiac conduction system.

    abstract:BACKGROUND:During heart development, the ventricular activation sequence changes from a base-to-apex to an apex-to-base pattern. We investigated the possibility of impulse propagation through remnants of atrioventricular (AV) connections in quail hearts. METHODS AND RESULTS:In 86 hearts (group A, HH30-34, n=15; group ...


    pub_type: 杂志文章


    authors: Kolditz DP,Wijffels MC,Blom NA,van der Laarse A,Markwald RR,Schalij MJ,Gittenberger-de Groot AC

    更新日期:2007-01-02 00:00:00

  • Impact of nonoperative therapy on the clinical management of peripheral arterial disease.

    abstract::Nonoperative therapy includes conservative noninterventional modalities and the endovascular interventional modalities of percutaneous transluminal angioplasty and a variety of laser systems and atherectomy devices. The role and impact of all nonoperative treatments are considered in the perspectives of the natural hi...


    pub_type: 杂志文章,评审


    authors: Veith FJ,Gupta SK,Wengerter KR,Rivers SP,Bakal CW

    更新日期:1991-02-01 00:00:00

  • Effects of the beta 1-adrenergic receptor partial agonist xamoterol on left ventricular diastolic function. An evaluation after 1-6 years of oral therapy.

    abstract::Acute intravenous administration of the new beta 1-adrenergic receptor partial agonist xamoterol lowers left ventricular end-diastolic pressure and improves the isovolumic indexes of inotropic state and relaxation. To determine if these hemodynamic changes were maintained after prolonged administration, the dose-respo...


    pub_type: 杂志文章


    authors: Pouleur H,Etienne J,Van Mechelen H,Gurné O,Rousseau MF

    更新日期:1990-02-01 00:00:00

  • Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation.

    abstract:BACKGROUND:Unstable atherosclerotic lesions typically have an abundant inflammatory cell infiltrate, including activated T cells, macrophages, and mast cells, which may decrease plaque stability. The pathophysiology of inflammatory cell recruitment and activation in the human atheroma is incompletely described. METHOD...


    pub_type: 杂志文章


    authors: Haley KJ,Lilly CM,Yang JH,Feng Y,Kennedy SP,Turi TG,Thompson JF,Sukhova GH,Libby P,Lee RT

    更新日期:2000-10-31 00:00:00

  • Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension.

    abstract:BACKGROUND:Myocardial afterload depends on left ventricular (LV) cavity size, pressure, and wall thickness, all of which change markedly throughout ejection. We assessed the relationship between instantaneous ejection-phase pressure and myocardial stress and the effect of arterial wave reflections on myocardial stress ...


    pub_type: 杂志文章


    authors: Chirinos JA,Segers P,Gupta AK,Swillens A,Rietzschel ER,De Buyzere ML,Kirkpatrick JN,Gillebert TC,Wang Y,Keane MG,Townsend R,Ferrari VA,Wiegers SE,St John Sutton M

    更新日期:2009-06-02 00:00:00

  • Multiple Arterial Grafting Is Associated With Better Outcomes for Coronary Artery Bypass Grafting Patients.

    abstract:BACKGROUND:Observational studies have shown better survival in patients undergoing coronary artery bypass grafting (CABG) with 2 arterial grafts compared with 1. However, whether a third arterial graft is associated with incremental benefit remains uncertain. We sought to analyze the outcomes of 3 versus 2 arterial gra...


    pub_type: 杂志文章,多中心研究


    authors: Rocha RV,Tam DY,Karkhanis R,Nedadur R,Fang J,Tu JV,Gaudino M,Royse A,Fremes SE

    更新日期:2018-11-06 00:00:00

  • High density lipoprotein metabolism in endurance athletes and sedentary men.

    abstract:BACKGROUND:Endurance athletes have higher high density lipoprotein (HDL) concentrations than sedentary controls. To examine the mechanism for this effect, we compared HDL apoprotein metabolism in 10 endurance athletes aged 34 +/- 6 years (mean +/- SD) and 10 sedentary men aged 36 +/- 8 years. METHODS AND RESULTS:Subje...


    pub_type: 杂志文章


    authors: Thompson PD,Cullinane EM,Sady SP,Flynn MM,Chenevert CB,Herbert PN

    更新日期:1991-07-01 00:00:00

  • Human platelet Ca2+ mobilization, glycoprotein IIb/IIIa activation, and experimental coronary thrombosis in vivo in dogs are all inhibited by the inotropic agent amrinone.

    abstract:BACKGROUND:Inotropic drugs are often used to treat acute, severe heart failure resulting from acute myocardial infarction and other unstable coronary artery syndromes. However, catecholamine inotropic agents may potentiate coronary thrombosis via a platelet alpha2-adrenergic mechanism, thus exacerbating the original pr...


    pub_type: 杂志文章


    authors: Sill JC,Bertha B,Berger I,Uhl C,Nugent M,Folts J

    更新日期:1997-09-02 00:00:00

  • Incidence, Cause, and Comparative Frequency of Sudden Cardiac Death in National Collegiate Athletic Association Athletes: A Decade in Review.

    abstract:BACKGROUND:The incidence and cause of sudden cardiac death (SCD) in athletes is debated with hypertrophic cardiomyopathy often reported as the most common cause. METHODS AND RESULTS:A database of all National Collegiate Athletic Association deaths (2003-2013) was developed. Additional information and autopsy reports w...


    pub_type: 杂志文章,评审


    authors: Harmon KG,Asif IM,Maleszewski JJ,Owens DS,Prutkin JM,Salerno JC,Zigman ML,Ellenbogen R,Rao AL,Ackerman MJ,Drezner JA

    更新日期:2015-07-07 00:00:00

  • Effects on coagulation and fibrinolysis with reduced versus full systemic heparinization and heparin-coated cardiopulmonary bypass.

    abstract:BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...


    pub_type: 临床试验,杂志文章


    authors: Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

    更新日期:1995-11-01 00:00:00

  • Physical activity and coronary heart disease in men: The Harvard Alumni Health Study.

    abstract:BACKGROUND:The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors. METHODS AND RESULTS:We fo...


    pub_type: 杂志文章


    authors: Sesso HD,Paffenbarger RS Jr,Lee IM

    更新日期:2000-08-29 00:00:00

  • Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target.

    abstract:BACKGROUND:Excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs) are key mechanisms of pulmonary arterial hypertension (PAH). Despite the multiple combination therapy, a considerable number of patients develop severe pulmonary hypertension (PH) because of the lack of diagnost...


    pub_type: 杂志文章


    authors: Kikuchi N,Satoh K,Kurosawa R,Yaoita N,Elias-Al-Mamun M,Siddique MAH,Omura J,Satoh T,Nogi M,Sunamura S,Miyata S,Saito Y,Hoshikawa Y,Okada Y,Shimokawa H

    更新日期:2018-08-07 00:00:00

  • Transient intermittent lymphocyte activation is responsible for the instability of angina.

    abstract:BACKGROUND:Blood clotting activation is an important component of the inflammatory response; the outbursts of unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis. METHODS AND RESULTS:To investigate 1) whether monocyte activation is responsible for the enhanced thrombi...


    pub_type: 杂志文章


    authors: Serneri GG,Abbate R,Gori AM,Attanasio M,Martini F,Giusti B,Dabizzi P,Poggesi L,Modesti PA,Trotta F

    更新日期:1992-09-01 00:00:00

  • Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.

    abstract:BACKGROUND:The alpha1-adrenergic receptors (alpha1-ARs) play a key role in cardiovascular homeostasis. However, the functional role of alpha1-AR subtypes in vivo is still unclear. The aim of this study was to evaluate the cardiovascular influences of alpha1b-AR. METHODS AND RESULTS:In transgenic mice lacking alpha1-AR...


    pub_type: 杂志文章


    authors: Vecchione C,Fratta L,Rizzoni D,Notte A,Poulet R,Porteri E,Frati G,Guelfi D,Trimarco V,Mulvany MJ,Agabiti-Rosei E,Trimarco B,Cotecchia S,Lembo G

    更新日期:2002-04-09 00:00:00

  • Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American Coll

    abstract:OBJECTIVES:To determine, using systematic review of the biomedical literature, whether pacing reduces risk of recurrent syncope and relevant clinical outcomes among adult patients with reflex-mediated syncope. METHODS:MEDLINE (through PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (through Oct...


    pub_type: 杂志文章,meta分析,评审


    authors: Varosy PD,Chen LY,Miller AL,Noseworthy PA,Slotwiner DJ,Thiruganasambandamoorthy V

    更新日期:2017-08-01 00:00:00

  • Contribution of superior vena caval flow to total cardiac output in children. A Doppler echocardiographic study.

    abstract:BACKGROUND:After a cavopulmonary anastomosis, the superior vena caval flow, by virtue of being the effective pulmonary blood flow, is the most important factor influencing the systemic arterial saturation. Determination of the amount of this blood flow will allow a better understanding of the physiology of the circulat...


    pub_type: 杂志文章


    authors: Salim MA,DiSessa TG,Arheart KL,Alpert BS

    更新日期:1995-10-01 00:00:00

  • Fluid restitution and blood volume redistribution in anesthetized rabbits in response to vasoactive drugs.

    abstract:BACKGROUND:Vasoactive drugs could alter the fluid restitution from the tissue and redistribute blood volume between the macrocirculation and microcirculation. METHODS AND RESULTS:With bolus injections of vasoactive drugs in anesthetized rabbits, we measured the changes in blood and plasma density for the determination...


    pub_type: 杂志文章


    authors: Anderson SM,Rich GF,Roos C,Lee LP,Lee JS

    更新日期:1994-07-01 00:00:00