Abstract:
PURPOSE OF REVIEW:Alcohol dependence is a complex disorder with a well documented highly hereditary nature. This article reviews the recent advances in our understanding of the direct and indirect genetic influences on alcohol use and dependence. RECENT FINDINGS:Recent findings can be summarized as follows: (a) twin studies have defined and estimated the risks of general and specific alcohol-related vulnerabilities. (b) Linkage studies have provided largely inconsistent findings, though several chromosomal regions have been implicated. (c) Quantitative trait loci analyses in animals have identified that the Mpdz gene predisposes to alcohol dependence and withdrawal. (d) Examination of family-based samples has identified several genes including GABRA2 and CHRM2 thought to be associated with alcohol dependence. SUMMARY:Despite great advances in understanding of genetic vulnerability in alcohol use disorders, only two gene complexes, ADH and ALDH2, have been identified as having defined effects on alcohol use and liability to dependence in humans. New genes associated with increased risks for the disorder will certainly be added to this list in the near future. Neurobiological analyses of the effects of these genes will surely contribute to further understanding of the cause of alcohol dependence and the interindividual differences in risks.
journal_name
Curr Opin Psychiatryjournal_title
Current opinion in psychiatryauthors
Higuchi S,Matsushita S,Kashima Hdoi
10.1097/01.yco.0000218595.54054.7asubject
Has Abstractpub_date
2006-05-01 00:00:00pages
253-65issue
3eissn
0951-7367issn
1473-6578pii
00001504-200605000-00005journal_volume
19pub_type
杂志文章,评审abstract::A shift in accepted practice regarding sharing research led one editor to discuss adopting a legal rather than a moral stance to enforce ethical standards. Familiar ethical concerns regarding consent and balancing individual rights against those of others are considered, alongside lacunae in the field, by drawing on v...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/00001504-199909000-00002
更新日期:1999-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The perinatal period introduces a myriad of changes. One important but often overlooked change is the increased risk for sleep disturbance. Although casually regarded as a consequence of pregnancy or postpartum, there is emerging evidence to suggest that women with significant sleep disturbance, chara...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000206
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Attention-deficit and hyperactivity disorder (ADHD) often presents with comorbid substance use disorders (SUD). Due to similarities in key symptoms of both disorders and suboptimal efficacy of the available treatments, clinicians are faced with difficulties in the diagnosis and treatment of these pati...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000513
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This review examines progress being made in the treatment of cocaine abuse and dependence, with a particular focus on pharmacotherapies. Medications with apparently very different mechanisms of action have been reported to reduce cocaine use in controlled clinical trials in outpatient settings. This r...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/01.yco.0000165596.98552.02
更新日期:2005-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Social cognition training is an emerging intervention, which aims to ameliorate impairment in social interaction and improve functional outcomes in persons with a psychosis. This article reviews the research conducted on the impact of this intervention published in English language journals over the p...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283642cf1
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent epidemiology, biological and clinical findings correlate high cigarette consumption in patients with schizophrenia, impeding both treatment strategies and the effectiveness of antipsychotics. RECENT FINDINGS:New data suggests that despite world-wide efforts to curb cigarette consumption, smoki...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000529
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review covers the epidemiological research from developing countries to identify the scope of research in the various aspects of epidemiology and the strengths of research. The period covered is June 2004 to June 2005. The literature survey used searches of Medline, key psychiatric journals and p...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/01.yco.0000179499.23311.f3
更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Antipsychotic therapy has been eclipsed by high rates of noncompliance; the problem was attributed to a lack of efficacy and the burden of side effects of neuroleptics. This review sought to examine whether the arrival of second generation (atypical) antipsychotic drugs with low side-effect liability ...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3282f52851
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The present review focuses on atypical antipsychotics and tardive dyskinesia. RECENT FINDINGS:We have known for many years that clozapine has a diminished risk of tardive dyskinesia compared with typical antipsychotics. The last decade has seen the introduction of a number of other atypical antipsych...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328017f6b1
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Depression is a common and disabling disorder that affects people of all ages and 10% of those older than 65 years. Current strategies to decrease the personal and societal burden of depression in older age rely on the management of people with depression or of those at risk, but benefits have been li...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328356bd57
更新日期:2012-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To raise awareness of and inform evidence-based practice regarding medical and behavioral interventions for antipsychotic medication-induced metabolic abnormalities. RECENT FINDINGS:The current literature indicates that individuals with severe and persistent mental illness have significantly worse he...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328314b74b
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Overview on integrated care trials focusing on effectiveness and efficiency published from 2011 to 2013. RECENT FINDINGS:Eight randomized controlled trials (RCTs) and 21 non-RCT studies were published from 2011 to 2013. Studies differed in several methodological aspects such as study population, psyc...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328361ec3b
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:With increasing awareness of potential differences of autism presentation in nonmale versus male individuals, this review summarizes the rapidly evolving literature on sex and gender impacts on autism across nosology, behavioural presentation, developmental change and contextual recognition biases. R...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000575
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Considerable progress has been made in the neurobiological understanding of expectations in physiological and pathological processes. This article is aimed at presenting an overview of the role of expectations in producing health-related effects. We selected recent laboratory and clinical studies in t...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328343803b
更新日期:2011-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Behavioral medicine is a vast field with an ever-increasing knowledge base. We review important findings over the last 18 months. RECENT FINDINGS:We organized advances in behavioral medicine into four main topic areas: the doctor and patient, health-related behavior, integration of behavioral medicin...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283503576
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Women are more impacted by Alzheimer's disease than men - they are at significantly greater risk of developing Alzheimer's disease, and recent research shows that they also appear to suffer a greater cognitive deterioration than men at the same disease stage. The purpose of this article is to review r...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000401
更新日期:2018-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review considers the literature on ethical and conceptual issues in eating disorders from the last 18 months. Some reference to earlier work is necessary in order to provide context for the recent findings from research that is ongoing. RECENT FINDINGS:Empirical ethics research on anorexia nervo...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e328365a3a1
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:In African countries, the biggest killers of young children are respiratory infections and diarrhoeal disease, and both are preventable via hand washing. Regular tooth brushing, at least twice a day, is one of the most effective methods for the control and prevention of dental caries and periodontal d...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32834fda33
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Behavioral medicine is an interdisciplinary field, integrating research from a variety of disciplines. This review focuses on recent advances and developments in behavioral medicine. RECENT FINDINGS:Stress, as well as having a role in the etiology and maintenance of somatic disease and somatoform dis...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/01.yco.0000214345.37002.77
更新日期:2006-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Alcohol is widely available and one of the most commonly used psychoactive substances. This review examined the recent literature for empirical research addressing the cause, prevalence and treatment of alcohol-related problems in adolescents and adults with intellectual disabilities. RECENT FINDINGS...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/01.yco.0000238474.07078.41
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Mental disorders take a major toll, economically, socially, and psychologically, on individuals, families, and societies. Prevention provides an important and realistic opportunity to overcome this major health problem. This review outlines a conceptual framework for mental health prevention and effec...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000076
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Over 70 million people worldwide, including those with neurodegenerative disease (NDD), have been diagnosed with coronavirus disease 2019 (COVID-19) to date. We review outcomes in patients with NDD and COVID-19 and discuss the hypothesis that due to putative commonalities of neuropathogenesis, COVID-1...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000688
更新日期:2021-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Pilowsky introduced the term 'abnormal illness behaviour' to characterize syndromes of excessive or inadequate response to symptoms, including hypochondriasis, somatization, and denial of illness. This review summarizes recent work from sociology, health psychology and psychiatry that contributes to a...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/01.yco.0000194810.76096.f2
更新日期:2006-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Since the last review of Williams syndrome in Current Opinion (2001) there have been many advances in knowledge about the cognitive, social and psychological impairments that characterize the disorder. The present review focuses on current research in these areas. RECENT FINDINGS:Williams syndrome is...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000477
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to summarize data published in the scientific literature and available on official websites on fetal alcohol spectrum disorder (FASD) in Africa. RECENT FINDINGS:There is a paucity of published literature and evidence-based information on prenatal exposure to alcohol in the African co...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:10.1097/YCO.0000000000000315
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Economic evaluation is becoming more and more important as a means to assist policy makers in choosing the best intervention or treatment against a pervasive scarcity of resources relative to the demands. Health service provision and the practice of geriatric psychiatry are closely associated with cos...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32830f1bd5
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the influence of personality disorder comorbidity on the general treatment of mood disorders. RECENT FINDINGS:Personality disorders generally have a negative influence on outcome of mood disorders, both unipolar and bipolar. When the personality features are addressed, however, the outcome...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:In recent years, deficits in emotion regulation have been studied as a putative maintaining factor and promising treatment target in a broad range of mental disorders. This article aims to provide an integrative review of the latest theoretical and empirical developments in this rapidly growing field ...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e3283503669
更新日期:2012-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this study is to provide a review of articles published between July 2007 and August 2008 on the current use and rationale of benzodiazepines in anxiety disorders. RECENT FINDINGS:Recent review articles confirm selective serotonin reuptake inhibitors as first-choice drugs for treating anxi...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0b013e32831a473d
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. RECENT FINDINGS:Patien...
journal_title:Current opinion in psychiatry
pub_type: 杂志文章,评审
doi:10.1097/YCO.0000000000000108
更新日期:2014-11-01 00:00:00